Ultrastructural changes of tissues produced by inhalation of thinner in rats

Carabez-T., Alfonso; Sandoval, Francisca; Palma, T Lourdes

doi:10.1002/(sici)1097-0029(19980101)40:1<56::aid-jemt8>3.0.co;2-v

Cited by 23 publications

(9 citation statements)

References 30 publications

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“…Various neurotoxic effects of toluene or thinner such as memory impairment, behavioural, electroencephalographic and neuropathological changes have been reported in the rat. [8][9][10] Several organic solvents have been suggested to impair neurochemical mechanisms in the brain which control hypophyseal gonadotropin release. 1,11,12) There is very limited literature on the effects of paint thinner inhalation on male reproductive functions.…”

Section: -7)mentioning

confidence: 99%

Effects of Paint Thinner Exposure on Serum LH, FSH and Testosterone Levels and Hypothalamic Catecholamine Contents in the Male Rat.

Yılmaz

Kutlu

Canpolat

et al. 2001

Biological & Pharmaceutical Bulletin

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Section: -7)mentioning

confidence: 99%

Effects of Paint Thinner Exposure on Serum LH, FSH and Testosterone Levels and Hypothalamic Catecholamine Contents in the Male Rat.

Yılmaz

Kutlu

Canpolat

et al. 2001

Biological & Pharmaceutical Bulletin

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“…These intermediates may bind covalently to proteins, lipids, DNA or RNA, and may inactivate receptors and proteins, damage cellular membranes or initiate mutagenic reactions (2). ROS are believed to cause lipid peroxidation, which in turn damages biological membranes (3). Antioxidants such as enzymatic and nonenzymatic defence systems are necessary to prevent cellular damage (4).…”

mentioning

confidence: 99%

How Volatile Organic Compounds Affect Free Radical and Antioxidant Enzyme Activity in Textile Workers

Bayıl¹,

Çiçek²,

Çimenci³

et al. 2008

Archives of Industrial Hygiene and Toxicology

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Various effects of exposure to volatile organic compounds (VOC) have recently become an important issue because of their widespread use in industry. The aim of this study was to determine the effect of volatile organic solvents commonly used in textile paint industry on free radical levels and the antioxidant enzyme system in textile workers. The study included twenty exposed workers and twenty controls. Blood samples were taken after an overnight fast of 10 to 12 hours. Malondialdehyde (MDA) and total antioxidant capacity (TAC) were studied in serum while super oxide dismutase (SOD) activity was studied in erythrocytes. Statistical analysis was performed using the ANOVA and Kruskall-Wallis analysis tests. MDA and SOD were significantly higher in textile workers than in controls (p<0.01). In contrast, no significant difference was observed between them for TAC (p>0.05). Elevated MDA levels in textile workers may indicate increased lipid peroxidation as a result of long-term exposure to organic solvents, whereas elevated SOD activity suggests that the antioxidant system was activated to counter lipid peroxidation. The results suggest that textile workers occupationally exposed to volatile organic solvents make a risk group and require more frequent periodic examinations.

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“…In humans and mice, organic solvents produce physiological impairment of brain function following acute exposure [2,25,32]. Acute inhalation of thinner, a kind of organic solvent, induces ultrastructural alteration of the liver, adrenal gland and CNS [3]: modifications in liver are a massive accumulation of glycogen, an increase of lipid droplets, the presence of numerous lysosomes and enlarged Golgi complex in the hepatocyte, and the deposition of the fibrous and collagen like materials between cells; some mitochondria in zona fasciculata of adrenal cortex became "megamitochondria" as described in literatures in alcoholism [1], cuprizone intoxication [24]; cerebral brain cortex shows an increase in the distance of intersynaptic space, a diminution of membrane density at postsynaptic membrane and modifications of size and shape of mitochondria in the neurons. We suspect that acute toluene inhalation and higher concentrations of formaldehyde might cause extensive dilatation of the sinusoid by acting directly on the anterior pituitary gland.…”

Section: Discussionmentioning

confidence: 91%

“…The volume of the anterior pituitary (V) was calculated as V = 5 × 10 × ∑A i µm 3 . The percentage and number of ACTH-ir cells were determined using a square of side 40 µm drawn at × 400 magnification on the screen of a personal computer [17].…”

Section: Animals and Exposurementioning

confidence: 99%

Hypothalamo-Pituitary-Adrenal Gland Axis in Mice Inhaling Toluene Prior to Low-Level Long-Term Exposure to Formaldehyde

Sari

Kuwahara

Furuya

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. We studied the change in the hypothalamo-pituitary-adrenal gland (HPA) axis upon adding prior toluene inhalation to our previous formaldehyde inhalation experiments to determine whether short term exposure to relatively high levels of toluene triggers multiple chemical sensitivity (MCS). Data come from immunocytochemical, morphometrical and RT-PCR measurements. Four groups of adult female mice were exposed to differing concentrations (0, 80, 400, and 2,000 ppb) of formaldehyde for 16 hr/day, 5 days/week for twelve weeks, after the mice were exposed intranasally to 500 ppm toluene per mouse for 6 hr/day, for 3 days. We found that the number of corticotropin releasing hormone (CRH)-immunoreactive (ir) neurons was up-regulated according to the amount of formaldehyde as well as inhalation of formaldehyde alone in our previous experiment. The proportion of adrenocorticotropin hormone (ACTH)-ir cells increased according to the formaldehyde concentration, though there was no significant difference between the 400 and 2,000 groups. The number of ACTH-ir cells was higher in the 400 group than in the other groups (0, 80, and 2,000). Expression of ACTH-mRNA was also up-regulated according to the quantity of formaldehyde. The sinusoid in the anterior pituitary showed more dilatation in the 400 and 2,000 groups than in the control group, especially in the 2,000 group. We propose that exposure to toluene prior to inhalation of formaldehyde has no effect on the HPA axis and as a trigger of MCS, although greater sinusoid dilatation was found in the anterior pituitary gland at higher concentrations of formaldehyde.

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Ultrastructural changes of tissues produced by inhalation of thinner in rats

Cited by 23 publications

References 30 publications

Effects of Paint Thinner Exposure on Serum LH, FSH and Testosterone Levels and Hypothalamic Catecholamine Contents in the Male Rat.

Effects of Paint Thinner Exposure on Serum LH, FSH and Testosterone Levels and Hypothalamic Catecholamine Contents in the Male Rat.

How Volatile Organic Compounds Affect Free Radical and Antioxidant Enzyme Activity in Textile Workers

Hypothalamo-Pituitary-Adrenal Gland Axis in Mice Inhaling Toluene Prior to Low-Level Long-Term Exposure to Formaldehyde

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