1987
DOI: 10.1002/aja.1001780105
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Ultrastructural differentiation of stromal and vascular components in early macaque placental villi

Abstract: In this study, closely staged placental villi from rhesus monkeys between 19 and 60 days of gestation were used to examine 1) the origin of endothelial cells and the mechanism of angiogenesis in villi; 2) the origin of placental macrophages (Hofbauer cells), and 3) the origin of the reticular cells that compartmentalize the stroma. The results did not support the concept that early stromal cells in the villi were derived by in situ delamination from cytotrophoblast. The extraembryonic mesodermal (mesenchymal) … Show more

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Cited by 72 publications
(48 citation statements)
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“…Knowing the site of initial crystallization would improve understanding of the pathogenesis of stone formation and allow investigators to propose and test more focused hypotheses. This would help them to devise effective therapy aimed at preventing recurrent nephrolithiasis, which afflicts approximately 50% of stone formers within five years of the initial stone (6). Yet until the elegant study by A.P.…”
Section: Site Of the Initial Solid Phasementioning
confidence: 99%
See 1 more Smart Citation
“…Knowing the site of initial crystallization would improve understanding of the pathogenesis of stone formation and allow investigators to propose and test more focused hypotheses. This would help them to devise effective therapy aimed at preventing recurrent nephrolithiasis, which afflicts approximately 50% of stone formers within five years of the initial stone (6). Yet until the elegant study by A.P.…”
Section: Site Of the Initial Solid Phasementioning
confidence: 99%
“…For the fetus to develop normally, it must receive sufficient oxygen and nutrients (6). These are supplied via the maternal spiral arteries in the uterus.…”
Section: Sflt1: a Likely Candidate Preeclampsia Factormentioning
confidence: 99%
“…An effective vascular plexus is fully formed by the end of the first trimester (12 weeks) by vasculogenesis and angiogenesis. Several studies in the 1980s using both the macaque monkey [2]and first-trimester human placenta [1]proposed the ultrastructural sequence of events for vasculogenesis – i.e., mesenchymal stem cells aggregate and differentiate into hemangioblasts, and the innermost cells within an aggregate become haemopoietic whilst the abluminal cells become pericytes. Dilation of paracellular clefts between pre-endothelial cells has been proposed as the mechanism behind lumen formation.…”
Section: Introductionmentioning
confidence: 99%
“…Early studies had already found that the most striking aspects of HBCs are their highly vacuolated appearance and their granulated cytoplasm 2 . Later investigations have pointed out that HBCs are characterized by numerous membrane-bound, electron-lucent vacuoles of different sizes, possessing amorphous material of varying density, dense granules (presumably lysosomes), and short profiles of endoplasmic reticulum 1,[3][4][5][6][7] .…”
Section: Introductionmentioning
confidence: 99%