Ultrastructural Effects of Hypercholesterolemia on the Cochlea

Satar, Bülent; Özkaptan, Yalçın; Surucu, H. Selcuk; Öztürk, Hakan

doi:10.1097/00129492-200111000-00012

Cited by 50 publications

(42 citation statements)

References 13 publications

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“…Satar and colleagues noted hearing loss and stria vascularis pathology in guinea pigs fed a highcholesterol diet. 36 Similarly, chinchillas on a high-lipid diet had pathological changes in the stria and outer hair cells. 37 A rabbit study showed that hypertension and high cholesterol had additive effects on hearing although, interestingly, low-frequency hearing improved, whereas high-frequency hearing declined.…”

Section: Discussionmentioning

confidence: 99%

Audiometric pattern as a predictor of cardiovascular status: Development of a model for assessment of risk

2009

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Section: Discussionmentioning

confidence: 99%

Audiometric pattern as a predictor of cardiovascular status: Development of a model for assessment of risk

2009

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“…Diabetes mellitus is a well-established risk factor for atherosclerosis and microvascular disorders in the coronary, cerebral and peripheral regions [Marcucci et al, 2005]. A similar role in the impairment of cochlear perfusion, which is a vascular region provided with a terminal capillary bed, is biologically conceivable [Marcucci et al, 2005;Mercier et al, 1999;Satar et al, 2001;Suzuki et al, 2008]. Nevertheless, there are only few reports in the literature concerning the relationship between diabetes mellitus and ISSNHL.…”

Section: Discussionmentioning

confidence: 99%

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

et al. 2009

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Aims/Hypothesis: Idiopathic sudden sensorineural hearing loss (ISSNHL) represents an acute inner ear disorder with an overall incidence of 5–20/100000 individuals per year in western countries. No clear causes for this disease have been found so far, but cochlear ischemia has been hypothesized as one of the etiopathological mechanisms. The aim of our study was to assess the role of diabetes and traditional cardiovascular risk factors in the pathogenesis of ISSNHL. Materials/Methods: Case-control study of 141 patients (75 males/66 females) matched for age and gender. Cases were affected by ISSNHL, defined as a sudden hearing loss ≧30 dB, within 3 frequencies, developing over 72 h. The control group was composed of 271 sex- and age-matched subjects (142 males/129 females) who agreed to participate in this observational study and provided blood samples for laboratory investigations. Cardiovascular risk factors examined were: diabetes mellitus, smoking history, hypercholesterolemia, hypertriglyceridemia and hypertension. Results: On the univariate analysis, diabetes prevalence was higher in the ISSNHL group (15.6%) compared to controls (8.5%) (p = 0.03). Also hypercholesterolemia was significantly more frequent in the ISSNHL group compared to the control population. There were no statistically significant differences between the 2 populations concerning other cardiovascular risk factors. The risk of ISSNHL tended to increase as the number of cardiovascular risk factors increased (p for linear trend = 0.018). Conclusions: Our findings suggest that diabetes mellitus, hypercholesterolemia and a high burden of cardiovascular risk factors are associated with the risk of ISSNHL.

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“…However, impaired angiogenesis may also be involved in the decreased capillary density because hyperlipidemia attenuates angiogenesis in limbs [27,33] . The decreased capillary density may be responsible for lower blood flow in the stria vascularis, and for profound intercellular edema in the marginal layer of the stria vascularis of the hyperlipidemic animal models [5,34] .…”

Section: Discussionmentioning

confidence: 99%

Impaired Stria Vascularis in the Inner Ear of Apolipoprotein E Gene Knockout Mice

Zhu

Du²,

Cai³

et al. 2008

ORL

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Purpose: To study apoptotic cell death, the expression of endothelial nitric oxide synthase (eNOS) and the capillary density in the cochleae of apolipoprotein E gene knockout (ApoE KO) mice. Methods: Cochleae of ApoE KO mice were stained by HE, anti-caspase-3 and anti-eNOS antibodies and TUNEL (in situ terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling). Capillary density was measured in the stria vascularis and in the modiolus. Results: Apoptotic cell death was found in the stria vascularis of ApoE KO mice, but not in the organ of Corti. The expression of eNOS and the capillary density were decreased in the stria vascularis and in the modiolus of ApoE KO mice. Conclusion: These results suggest that cells in the inner ear of ApoE KO mice take different pathways to undergo cell death, and apoptotic cell death is only involved in the stria vascularis. These pathological changes may play a role in the hearing loss that has been found in ApoE KO mice.

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Ultrastructural Effects of Hypercholesterolemia on the Cochlea

Cited by 50 publications

References 13 publications

Audiometric pattern as a predictor of cardiovascular status: Development of a model for assessment of risk

Audiometric pattern as a predictor of cardiovascular status: Development of a model for assessment of risk

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Impaired Stria Vascularis in the Inner Ear of Apolipoprotein E Gene Knockout Mice

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