Ultrastructural effects of norethynodrel and mestranol on human endometrial stroma cell

Wienke, Eugene C.; Cavazos, Filiberto; Hall, David G.; Lucas, Fred V.

doi:10.1016/s0002-9378(16)34350-2

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…The strong influence of progestational agents on endometrial carcinoma seen clinically and morpho logically [Wienke et al, 1969;Maruffo et al, 1974;Ferenczy, 1980;Kauppila et al, 1985], with suppres sion of tumor growth, has been attributed to an in crease in secretory activity and accelerated auto phagocytosis and apoptosis [Anderson, 1972], A mor phologically detectable increase in the degree of dif ferentiation of endometrial cancer cells after treat ment with the progestional medroxyprogesterone acetate [Kauppila et al, 1985] was paralleled in this study by deposits of regularly distributed collagen. These neoplasms contained, however, less collagen than similar untreated ones.…”

Section: Discussionmentioning

confidence: 99%

Collagen Type III Formation and Distribution in the Uterus: Effects of Hormones and Neoplasm Development

Stenbäck

1989

Oncology

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The amount and location of interstitial collagen in the endometrial stroma and the uterine wall as well as the effects of hormonal stimulation and neoplastic transformation were studied by light and electron microscopy and immunohistochemical methods using specific antibodies to aminoterminal propeptide type III procollagen (PIIIP). The results showed collagen deposition in atrophic mucosae and in the proliferative endometrium with a decrease in the secretory endometrium. In cystic glandular hyperplasia and adenomatous hyperplasia, PIIIP deposits were abundant. In well-differentiated endometrial adenocarcinoma, dense collagen type III aggregates were found in subepithelial positions, disintegrating with advancing malignancy and decreasing in hormonal-treated morphologically well-differentiated neoplasms. The even distribution of PIIIP around muscle cells and bundles in leiomyomas was disturbed and partly absent in leiomyosarcomas, and surrounded epithelial islets in mixed mesodermal tumors.

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Section: Discussionmentioning

confidence: 99%

Collagen Type III Formation and Distribution in the Uterus: Effects of Hormones and Neoplasm Development

Stenbäck

1989

Oncology

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“…As described above, progestins clearly interfere with stromal cell morphology. In women using high doses of a 19‐norsteroid progestin, a strong predecidual reaction is found in the stroma, and the endoplasmic reticulum is hyperplastic 10 . This particular stromal reaction seems to be more a sign of progestin exposure than the other aspects depending on the type of formula administered.…”

Section: Endometrial Modifications Following Hormonal Contraceptive Usementioning

confidence: 98%

The Endometrial Approach in Contraception

Lévy

Christin-Maître

Leroy

et al. 1997

Annals of the New York Academy of Sciences

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“…Depending on the dose of progestogen, a distinct predecidual or decidual change may occur as early as day 15 to 20 of the cycle. 10 With progestin doses Figure 1. After several cycles of a combination estrogenprogestin regimen the endometrial glands are small and lined by inactive epithelium.…”

Section: Combination Schedulesmentioning

confidence: 99%

“…The endometrium on ultrastructure analysis displays a predominance of progesterone-dependent features. 10 Golgi apparatus development and maximal synthesis of glycogen, protein, and carbohydrate occur by day 10. 13 However, the quantities of rough endoplasmic reticulum, ribosomes, and Golgi apparatus which are usually at their maximum in the secretory phase of an untreated menstrual cycle have already declined by day 15 of an oral contraceptive cycle.…”

Section: Combination Schedulesmentioning

confidence: 99%