Ultrastructural findings in feline corneal sequestra

Cullen, Cheryl L.; Wadowska, Dorota; Singh, Amreek; Melekhovets, Yuri

doi:10.1111/j.1463-5224.2005.00402.x

Cited by 31 publications

(44 citation statements)

References 24 publications

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“…Previous studies have also tried to elucidate the source of the brown color of sequestra in hopes of determining the exact pathogenesis of sequestrum formation. Feline herpes virus‐1 has been proposed to play a role, but cats with sequestra are not consistently herpes positive by PCR, and many unaffected cats are positive for herpes 2,13–16 . Tear film break‐up times and goblet cell numbers in the conjunctiva of normal and affected cats have been evaluated and are similar 16 .…”

Section: Discussionmentioning

confidence: 99%

“…In the past some have believed this pigment to be iron, but both a normal cornea and three sequestra had very low levels of iron 17,18 . One study used optical microscopy to examine the sequestra and concluded that the dark particles seen were consistent with melanin, but this was not supported by an electron microscopy study 15,17 …”

Section: Discussionmentioning

confidence: 99%

“…Feline herpes virus-1 has been proposed to play a role, but cats with sequestra are not consistently herpes positive by PCR, and many unaffected cats are positive for herpes. 2,[13][14][15][16] Tear film break-up times and goblet cell numbers in the conjunctiva of normal and affected cats have been evaluated and are similar. 16 The finding of decreased total lipids in the tears of affected cats led to the proposition that this altered tear film predisposes the corneas to desiccation, but a mechanism for sequestrum formation was still not determined.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 One study used optical microscopy to examine the sequestra and concluded that the dark particles seen were consistent with melanin, but this was not supported by an electron microscopy study. 15,17 Unfortunately the source of the coloration of sequestra remains an enigma. In humans, long term use of topical epinephrine is reported to cause conjunctival and corneal discoloration.…”

Section: Discussionmentioning

confidence: 99%

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Porphyrins are not present in feline ocular tissues or corneal sequestra

Newkirk¹,

Hendrix

Keller³

2011

Veterinary Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Porphyrins are not present in feline ocular tissues or corneal sequestra

Newkirk¹,

Hendrix

Keller³

2011

Veterinary Ophthalmology

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“…hereditary [1], feline herpes Virus -1 [2,3] conformational, tear film abnormalities [4][5][6], Toxoplasma gondii [7] but it is most commonly associated with ocular injury and inflammation [4,8]. The condition is a distinctive corneal lesion observed particularly in felines [9].…”

Section: Introductionmentioning

confidence: 99%

Surgical Outcome and Histopathological Findings of Feline Corneal Sequestrum

Hazra¹

2016

SOJVS

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SOJ Veterinary SciencesOpen Access Case Report needs extended period for sequestrum to loosen and slough off. Causes and mechanisms leading to corneal sequestration remain undefined. Recurrence of the lesion can occur at the original site after surgical removal. Various studies have been conducted to identify the pathophysiology of feline sequestrum, based on the tissue analysis of the sequestrum. In this case report, we describe the success of surgical outcome; determine tissue changes in feline sequestrum and the recurrence at a new site following surgical resection. Materials and MethodsA 4-year-old spayed female cat was examined for "a black spot" on the central cornea of left eye leading to ocular irritation and discomfort persistent for the past one month; owner also reported of excessive lacrimation for the initial few days. Owner revealed a history of corneal injury one month prior to the presentation while she was playing with other mates. The local veterinarian prescribed a topical antibiotic, and after one-month follow-up, the patient was referred to the centre. General examination was performed; pupillary reflex-direct and consensual was performed. Schirmer's tear test and fluorescein dye test was performed in both eyes. The affected eye was examined under slit lamp biomicroscopy.Based on history and clinical findings the condition was diagnosed as corneal sequestrum and a surgery was planned to relieve the discomfort. Routine blood examination for blood count, serum biochemical evaluation for blood sugar, kidney function was performed prior to anaesthesia to ensure no abnormalities. Anaesthesia was induced with a combination of Xylazine HCL @ 1 mg/kg and Ketamine HCL @ 5 mg/kg IM, and Diazepam @ 0.2mg/kg IV. Protective eye gel was applied to the right eye, and the left eye was prepared for aseptic surgery. Topical tropicamide and proparacaine were applied for mydriasis and corneal anesthesia respectively. Under the magnification of operating microscope, the surgery was performed. A corneal forceps was used to hold the lesion that was noticed to be loose superiorly and attached to the broad base, an 11 No scalpel blade was used to perform lamellar keratectomy and dissect out the Abstract Purpose: To evaluate the surgical outcome and histological features of feline corneal sequestrum following superficial keratectomy. Materials & Methods:Corneal sequestration was diagnosed in the left eye of a 4-year-old neutered female cat. After obtaining appropriate history, slit lamp biomicroscopy, Schirmer's tear test and fluorescein dye test was performed. Superficial keratectomy was performed under general and topical anesthesia. Post-operative care and management for the healing of the wound bed was instituted. The respected tissue was processed for histopathological evaluation. A follow-up for up to 1month was done to assess the surgical outcome. Result:The slit lamp biomicroscopy showed the involvement of the sequestration up to mid-stromal layer. Tear wetting following Schirmer's tear test was normal, and t...

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2012

Atlas of Feline Ophthalmology

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Ultrastructural findings in feline corneal sequestra

Abstract: Apoptosis may play a role in the pathogenesis of feline corneal sequestration independent of the presence of DNA of these infectious organisms. Prospective clinical studies are warranted to further understand the significance of T. gondii in relation to feline corneal sequestration.

Cited by 31 publications

References 24 publications

Porphyrins are not present in feline ocular tissues or corneal sequestra

Porphyrins are not present in feline ocular tissues or corneal sequestra

Surgical Outcome and Histopathological Findings of Feline Corneal Sequestrum

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