Ultrastructural findings in murine seminiferous tubules as a consequence of subchronic vanadium pentoxide inhalation

Fortoul, Teresa I.; Bizarro-Nevares, Patrícia; Acevedo-Nava, Sandra; Piñón-Zárate, Gabriela; Rodríguez-Lara, Vianey; Colı́n-Barenque, Laura; Mussali-Galante, Patricia; Ávila-Casado, Maria del Carmen; Ávila-Costa, Maria-Rosa; Saldivar-Osorio, Liliana

doi:10.1016/j.reprotox.2007.03.004

Cited by 32 publications

(13 citation statements)

References 23 publications

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“…Several commercial dietary supplements and multivitamins also contain vanadium in the range of 0.0004-12.5 mg. V is also widely used in the manufacturing of surgical implants, batteries, machinery, steel tools, in catalyst-based recycling processes, photographic developers, and semiconductors, oil refineries and power plants using vanadium-rich fuel oil and coal (Mussali-Galante et al 2005). However, there are no studies reporting its reproductive effects in humans, even if few studies investigated the reproductive toxicity of V into different experimental animals showing destructive spermatogenesis, necrosis of Sertoli cells, spermatocytes and spermatogonium, which is caused by chronic V ingestion and inhalation of vanadium pentoxide (Fortoul et al 2007). In this study, V concentration (ppb) in normozoospermic subjects ranged from 1.35 to 7.26 (median 1.6) in oligozoospermic 1.97-8.42 (median 1.08) and in azoospermic subjects 1.9-12.56 (median 4.99), as shown in Fig.…”

Section: Vanadium (V)mentioning

confidence: 99%

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Zafar

Eqani

Bostan

et al. 2014

Environ Geochem Health

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Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p < 0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r = -0.26, -0.29) and motility (r = -0.33, -0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan.

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Section: Vanadium (V)mentioning

confidence: 99%

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Zafar

Eqani

Bostan

et al. 2014

Environ Geochem Health

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“…Vanadium could also damage genetic material and induce hematotoxicity [3–5], immune toxicity [6], hepatotoxicity [7], lung toxicity [8–10], neurotoxicity [11–13], and reproductive toxicity [14–16] All these organs and systems are altered by vanadium inhalation, and in the next sections, we will describe the changes observed in our animal model, in an attempt to translate our findings to the actions that air-suspended particles could have on human health.…”

Section: Generalities Of Vanadiummentioning

confidence: 99%

Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Fortoul

Rodríguez-Lara

González-Villalva

et al. 2011

BioMed Research International

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There is an increased concern about the health effects that air-suspended particles have on human health which have been dissected in animal models. Using CD-1 mouse, we explore the effects that vanadium inhalation produce in different tissues and organs. Our findings support the systemic effects of air pollution. In this paper, we describe our findings in different organs in our conditions and contrast our results with the literature.

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“…In mice exposed to inhaled vanadium pentoxide (0.02 M) for 1 h twice a week, for 12 weeks, alterations were observed in the cells of the seminiferous tubules: necrosis, pseudo-nuclear inclusions and disruption of cellular junctions [211]; alterations were also found in proteins of the, such as decrease of gamma-tubulin [212] and actin [213].…”

Section: Reprotoxicity Of Metalsmentioning

confidence: 99%

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

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Ultrastructural findings in murine seminiferous tubules as a consequence of subchronic vanadium pentoxide inhalation

Cited by 32 publications

References 23 publications

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Health Effects of Metals in Particulate Matter

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