Ultrastructural immunocytochemistry of autoimmune bullous diseases

Karpouzis, Anthony; Vamvassakis, E.; Stavrianeas, N.; Koumantaki-Mathioudaki, Elma; Karpouzi, Myrsini; Vareltzides, A

doi:10.1046/j.1440-0960.2002.00571.x

Cited by 11 publications

(5 citation statements)

References 19 publications

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“…By direct IEM, the IgA deposits were found in lamina lucida, basal surface of hemidesmosomes, lamina densa and sublamina densa region [204]. "Mirror image" is defined as the IEM finding of several cases in which the immune deposits are located at the both sides of lamina densa [205].…”

Section: Diagnosismentioning

confidence: 99%

Acquired Epidermolysis Bullosa and Linear Immunoglobulin A Bullous Dermatosis

Çelik¹,

Atay²

2018

Autoimmune Bullous Diseases

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Acquired epidermolysis bullosa is a rare subepidermal bullous disease characterized by autoantibodies to type VII collagen, the major component of anchoring fibrils.Although the exact pathophysiologic mechanism remains unclear, reduction or perturbation of the anchoring fibrils results subepidermal blister formation and clinical features such as skin fragility, blisters, erosions, scars, milia and nail loss. Acquired epidermolysis bullosa includes various clinical manifestations resembling genetic epidermolysis bullosa, bullous pemphigoid, cicatricial pemphigoid, Brunsting-Perry pemphigoid and linear immunoglobulin A bullous dermatosis. Numerous treatment options are available but patients are often refractory to treatment. Linear immunoglobulin A bullous dermatosis is another subepidermal bullous disease characterized by the accumulation of IgA antibodies in lamina densa or sublamina densa region of the basement membrane and neutrophil-rich infiltrates in histopathology. It can be seen both in children and adults. The form seen in children usually begins under the age of 5 and it is called chronic bullous disease of childhood. The classical presentation is annular/polycyclic plaques and papules with blistering on perioral and perineal regions, giving a "cluster of jewels" appearance. The adult form is often seen after the fourth decade and clinical features are similar to those of dermatitis herpetiformis, bullous pemphigoid or cicatricial pemphigoid.

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Section: Diagnosismentioning

confidence: 99%

Acquired Epidermolysis Bullosa and Linear Immunoglobulin A Bullous Dermatosis

Çelik¹,

Atay²

2018

Autoimmune Bullous Diseases

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“…Direct and indirect immunogold electron microscopy can be useful to identifiy autoantibodies, complement, and fibrin deposits contributing to the diagnosis of rare entities (Hoang‐Xuan et al , 1999; Robin et al , 1999; Karpouzis et al , 2002), but the technique is difficult and expensive.…”

Section: Diagnosismentioning

confidence: 99%

Number III Mucous membrane pemphigoid

2005

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Mucous membrane pemphigoid (MMP) is a sub-epithelial vesiculobullous disorder. It is now quite evident that a number of sub-epithelial vesiculobullous disorders may produce similar clinical pictures, and also that a range of variants of MMP exist, with antibodies directed against various hemidesmosomal components or components of the epithelial basement membrane. The term immune-mediated sub-epithelial blistering diseases (IMSEBD) has therefore been used. Immunological differences may account for the significant differences in their clinical presentation and responses to therapy, but unfortunately data on this are few. The diagnosis and management of IMSEBD on clinical grounds alone is impossible and a full history, general, and oral examination, and biopsy with immunostaining are now invariably required, sometimes supplemented with other investigations. No single treatment regimen reliably controls all these disorders, and it is not known if the specific subsets of MMP will respond to different drugs. Currently, apart from improving oral hygiene, immunomodulatory-especially immunosuppressive-therapy is typically used to control oral lesions. The present paper reviews pemphigoid, describing the present understanding of this fascinating clinical phenotype, summarising the increasing number of subsets with sometimes-different natural histories and immunological features, and outlining current clinical practice.

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“…The Autoimmune Bullous Disease Quality of Life (ABQOL) questionnaire was developed in Australia as a patient-based measure to determine quality of life in patients with autoimmune bullous disease (AIBD) [3]. AIBD refer to a group of diseases characterized by the development of bullae and blistering as a result of autoimmunity to adhesion structures within the skin [4]. These diseases were previously associated with a guarded prognosis with secondary infection of bullae culminating in sepsis, however in the modern era with the advent of immunosuppressive therapies, AIBD tend to be chronic conditions with significant morbidity, and optimization of QOL is a more pertinent outcome of clinical care [5].…”

Section: Introductionmentioning

confidence: 99%