Ultrastructural localization of E‐cadherin and α‐/β‐catenin in adenoid cystic carcinoma

Shibuya, Yasuyuki; Ri, Shinshou; Umeda, Masahiro; Yoshikawa, Tomohiro; Masago, Hiroshi; Komori, Takahide

doi:10.1046/j.1365-2559.1999.035005423.x

Cited by 18 publications

(25 citation statements)

References 43 publications

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“…Although basal cell adenocarcinoma is similar to basal cell adenoma, it has infiltrative growth, cellular atypia or mitotic figures; however, differential diagnosis is often difficult. E-cadherin is part of the cell adhesion complex where it is associated with b-catenin, and loss of E-cadherin and b-catenin has been associated with invasion or metastasis in a wide variety of human malignancies (5)(6)(7). On the other hand, nuclear localization of b-catenin is also known in a wide variety of tumors, such as familial adenomatous polyposis, colorectal cancer, adrenocortical adenoma, hepatocellular adenoma, craniopharyngioma, and solid-pseudopapillary neoplasm or intraductal papillary mucinous neoplasm of the pancreas (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Nuclear β-catenin expression in basal cell adenomas of salivary gland

Kawahara

Harada

Abe

et al. 2011

Journal of Oral Pathology &Amp; Medicine

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Section: Introductionmentioning

confidence: 99%

Nuclear β-catenin expression in basal cell adenomas of salivary gland

Kawahara

Harada

Abe

et al. 2011

Journal of Oral Pathology &Amp; Medicine

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“…16,17 In the latter, a clear association was observed between mutation in b-catenin gene (CTNNB1) with tumorigenesis and tumor morphologic features. 18,19 Pleomorphic adenomas (PA) are the most common benign tumors of salivary glands. They occur more frequently in parotid, in young adults, slightly tending to females.…”

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confidence: 99%

Immunolocalization of β-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands

Genelhu¹,

Gobbi²,

Arantes³

et al. 2007

Applied Immunohistochemistry &Amp; Molecular Morphology

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Beta-catenin plays a central role in cadherin/catenin cell-cell adhesion complex and is involved in cell signaling pathway. Change in beta-catenin distribution has been associated with several human cancers including salivary gland tumors. We studied the immunolocalization of beta-catenin in a series of pleomorphic adenomas (PA) and carcinomas ex-pleomorphic adenomas (Ca ex-PA). Ten samples of PA and ten of Ca ex-PA were evaluated by immunohistochemistry using streptavidin-biotin-peroxidase technique and a monoclonal antibody against beta-catenin (E-5). Cell membrane/cytoplasmic staining of beta-catenin was observed in normal gland parenchyma, PA, and in well-differentiated Ca ex-PA. Cytoplasmic/nuclear beta-catenin staining was observed in poorly differentiated carcinomas and, interestingly, in one case of PA. Our data showed decreased cell membrane beta-catenin expression in higher-grade tumors suggesting that beta-catenin may play an important role in histologic differentiation and transition to malignant phenotype of Ca ex-PA.

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“…R-cadherin could not be found on the plasmalemma where axons or Schwann cells were in contact with the basal lamina. Our previous study demonstrated that there was no difference between the results by the HRP method and by the immunogold method (Shibuya et al 1996). Consequently, it was clear that the distribution of R-cadherin was the same as that of N-cadherin under electron microscopy.…”

Section: Discussionmentioning

confidence: 89%

Expression of R-cadherin in the regenerating chick sciatic nerve

Shibuya

Yasuda

Umeda

et al. 2001

Anatomy and Embryology

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The ultrastructural localization of R-cadherin in normal and regenerating chick sciatic nerves was investigated immunocytochemically, and was compared with that of N-cadherin. R-cadherin was found on the plasmalemmae of axons and Schwann cells where cell-cell contacts were made in the normal unmyelinated fibers. It was also noted that R-cadherin was expressed on the axolemmae where regenerating axons contacted with each other, and formed fasciculations. The normal myelinated fibers displayed no immunoreactivity except at the mesaxon. These findings of R-cadherin were almost the same as those of N-cadherin of our previous study. N- and R-cadherin seemed to be co-expressed at the cell-cell contact points as mentioned above in the double labeling study. It is probable that cadherins contribute to the pathfinding of regenerating axons by causing them to form fasciculation. However, it seemed that there was no selective sorting of axons by N- and R-cadherin during regeneration as far as the present study was concerned.

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Ultrastructural localization of E‐cadherin and α‐/β‐catenin in adenoid cystic carcinoma

Abstract: These findings suggest that the neoplastic cells of ACC express E-cad for use in intercellular adhesion, but the cadherin-catenin complex might not operate properly, which is the cause of neoplastic cell dissociation, followed by invasion and metastasis.

Cited by 18 publications

References 43 publications

Nuclear β-catenin expression in basal cell adenomas of salivary gland

Nuclear β-catenin expression in basal cell adenomas of salivary gland

Immunolocalization of β-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands

Expression of R-cadherin in the regenerating chick sciatic nerve

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