2009
DOI: 10.17525/vrrjournal.v14i1.21
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Ultrastructural Localization of Hepatitis C Virus Positive and Negative Strand Rna and Proteins in Hepatocytes of a Rhesus Monkey (Macaca Mulatta)

Abstract: Morphological alterations of the liver from rhesus macaque (Macaca mulatta)experimentally infected with hepatitis C virus (HCV) were analyzed using electron microscopy. The localization of viral RNA and proteins inside hepatocytes was demonstrated using in situ hybridization and immunoelectron microscopy techniques. The animals were inoculated by different routes. The infection was successful only by use of the intrasplenic approach to HCV infected autogenic hepatocyte transplant. The inoculum used to infect t… Show more

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