1972
DOI: 10.1017/s0424820100093729
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Ultrastructural Similarities Between Down's Syndrome Prensile Dementia and Alzheimer's Disease

Abstract: The presenile dementia which almost invariably complicates Down's syndrome after the fourth decade is histologically identical to Alzheimer's presenile dementia. Ultrastructural changes in Down's syndrome dementia (DSD) have not been reported thus far. If DSD meets the rigid ultrastructural criteria established for Alzheimer's disease, then an important predictable age-dependent reservoir of material is available for multi-disciplinary studies of the earliest changes of Alzheimer's disease and aging in the hum… Show more

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