Ultrastructural Studies on Developing Parotid Gland of the Rat at Early Postnatal Periods

Taga, Rumio; Sesso, Antônio

doi:10.1679/aohc1950.42.427

Cited by 56 publications

(39 citation statements)

References 22 publications

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“…However, the present study confirms previous reports of the presence of mixed acini both in the adult (Zimmermann, 1927;Du Plessis, 1957;Evans and Cruikshank, 1970;Iwata et al, 1977;Komori et al, 1979;Takeda et al, 1985) and in the terminal portion of newborn human accessory parotid glands (Zimmermann, 1898). According to Taga and Sesso (1979), the rat parotid gland also has mixed acini during its early development. The surgical anatomy of accessory parotid glands is of importance in several clinical situations.…”

Section: Discussionsupporting

confidence: 92%

Incidence and histology of human accessory parotid glands

et al. 1993

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The parotid glands of 228 Japanese human cadavers were examined to determine the incidence and histological features of accessory parotid glands. The incidence was found to be 56% with no differences between right and left sides or between sexes. Thirty parotid glands and their associated accessory glands were examined histologically: eight of these accessory glands were found to be mixed secretory glands (i.e., containing both serous and mucous acini). Thus, the pattern of differentiation of a significant fraction of accessory glands differs from that of the main parotid gland: it appears that mixed acini, present in the early stages of development, persist into later life, and their presence may be related to tumors developing at these sites.

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Section: Discussionsupporting

confidence: 92%

Incidence and histology of human accessory parotid glands

et al. 1993

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“…It has been shown that precursors of or immature myoepithelial cells are able to proliferate in cultured and transplanted human mammary glands (Joshi et al 1986) and during development of hamster Harderian (Lopez et al 1992), rat parotid (Taga and Sesso 1979;Redman et al 1980), and rat submandibular (Cutler and Chaudhry 1973) glands. In contrast, mature myoepithelial cells have been considered unable to prolif- erate (Cutler and Chaudhry 1973;Joshi et al 1986;Batsakis et al 1989) because they were end-differentiated cells (Batsakis et al 1989).…”

Section: Discussionmentioning

confidence: 99%

Apoptosis and Proliferation of Myoepithelial Cells in Atrophic Rat Submandibular Glands

Takahashi

Nakamura

Shinzato

et al. 2001

J Histochem Cytochem.

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S U M M A R YThis study was designed to determine whether apoptosis and proliferation of myoepithelial cells occur in atrophic rat submandibular glands. The excretory duct of the right submandibular gland was doubly ligated with metal clips. The atrophic right submandibular glands removed after 1-28 days of duct ligation were investigated using immunohistochemical double staining for actin as a marker for myoepithelial cells and proliferating cell nuclear antigen (PCNA) as a marker for proliferating cells, double staining for actin immunohistochemistry, nick end-labeling (TUNEL) as a marker for apoptotic cells, and transmission electron microscopy (TEM). A few PCNA-and no TUNEL-positive myoepithelial cells were found in the control submandibular glands taken from animals with no operation. In the experimental glands, PCNA-positive myoepithelial cells were common 2 and 3 days after duct ligation and then decreased in number. TUNEL-positive myoepithelial cells appeared at 2 days and were observed most frequently at 5 days. Apoptotic myoepithelial cells were also identified by TEM. These observations suggest that both apoptosis and proliferation of myoepithelial cells occur, especially in the early phase of atrophy, in the rat submandibular gland.

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“…MEC differentiation in salivary glands has been described in laboratory animals such as rat submandibular (Cutler and Chaudhry, 1973), sublingual (Redman, 1979), parotid glands (Redman, 1980;Taga, 1979) and hamster submandibular glands (Chaudhry et al , 1983). However, no published data are available on the perinatal development of MEC in bovine parotid gland, although these cells are known to occur in parotid glands of adult sheep and goat (Silver, 1954;van Lennep et al , 1977).…”

Section: Discussionmentioning

confidence: 99%