Ultrastructural study of a mucinous carcinoid of the skin

Abstract

A tumor of 60 years' duration overlying the sternum of an 87-year-old woman is described. Histologically, the tumor was composed of lobules and cords of epithelial cells with finely granular, eosinophilic cytoplasm. The epithelial nests were floating in large pools of mucinous stroma, separated by thin fibrovascular septa. Cytoplasmic argyrophilia was seen by Grimelius silver stain. Positive reactions of the tumor cells were also found for chromogranin and neuron-specific enolase. Ultrastructural study revealed that the cytoplasm of the tumor cells contained two types of granules: neurosecretory and mucinous. From these findings, the present tumor is considered to be a carcinoid tumor with amphicrine cells, and the term "mucinous carcinoid" of the skin seems to be appropriate for the diagnosis of the present case.

Cutaneous Metastases From Internal Malignancies

“…284 Carcinoid tumors from various anatomic locations may metastasize to skin, [285][286][287][288][289][290][291][292][293][294][295] the bronchus being the most frequent site for primary carcinoids producing cutaneous metastases. 292-294 A few cases of apparently primary cutaneous carcinoid tumors have been described, 292,[295][296][297] which may be difficult to differentiate from metastatic deposits. 292-294 A few cases of apparently primary cutaneous carcinoid tumors have been described, 292,[295][296][297] which may be difficult to differentiate from metastatic deposits.…”

Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review

“…[4][5][6][7][8][9][10][11][12][13][14][15] However, we believe that 4 of the 12 cases had features that were suggestive of other conditions. [4][5][6][7][8][9][10][11][12][13][14][15] However, we believe that 4 of the 12 cases had features that were suggestive of other conditions.…”

“…[4][5][6][7][8][9][10][11][12][13][14][15] However, we believe that 4 of the 12 cases had features that were suggestive of other conditions. "Mucinous carcinoid of the skin," which was previously described by Sakamoto et al, 9 appears consistent with breast cancer cases due to its large breast mass and the histologic mucin-producing features. "Mucinous carcinoid of the skin," which was previously described by Sakamoto et al, 9 appears consistent with breast cancer cases due to its large breast mass and the histologic mucin-producing features.…”

“…[4][5][6][7][8][9][10][11][12][13][14][15] Although the term "carcinoid" has been widely used since Oberndorfer first proposed the term in 1907, 16 this has been replaced with "neuroendocrine tumor" or "neuroendocrine carcinoma" when referring to other common sites for these tumors, including the gastrointestinal tract, 17 pancreas, 18 and breast. [4][5][6][7][8][9][10][11][12][13][14][15] Although the term "carcinoid" has been widely used since Oberndorfer first proposed the term in 1907, 16 this has been replaced with "neuroendocrine tumor" or "neuroendocrine carcinoma" when referring to other common sites for these tumors, including the gastrointestinal tract, 17 pancreas, 18 and breast.…”

Primary Cutaneous Neuroendocrine Carcinoma: Case with an Atypical Location

“…Primary cutaneous Neuroendocrine Tumor (NETs) is a very rare [1,2] with an approximate global incidence of 5.25 in 100,000 cases [3]: only ten cases have previously been reported in the literature [4][5][6][7][8][9][10][11][12][13]. These neoformations can vary enormously, both in their biological and clinical behavior, in terms of their which location, degree of differentiation and secretory activity [14,15].…”