Ultrastructural Study of Erythrocytes Containing Pappenheimer Bodies in a Case of Congenital Sideroblastic Anaemia (Csa)

Zarco, M. A.; Feliu, E; Rozmán, C; Masat, T; Aymerich, Maria S.; Jou, Josep M.; Aguilar, Juan; Corrons, Joan‐Lluís Vives

doi:10.1111/j.1365-2141.1991.tb04496.x

Cited by 9 publications

(6 citation statements)

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“…The observation of erythroblasts and red cells containing Pappenheimer bodies in peripheral blood, and ringed sideroblasts in the bone marrow reflected an intense erythrocytic sideroacrestic phenomenon. These abnormalities were facilitated in this patient because of the lack of the pitting function of the spleen due to previous splenectomy [15]. The cytologic and cytogenetic abnormalities disappeared within a short time (3 months) after discontinuation of the treatment with imatinib for only 1 month and reinitiation at a lower dose.…”

Section: Discussionmentioning

confidence: 83%

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Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia‐positive chronic myeloid leukemia: Two cases with a different outcome

et al. 2007

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Chromosomal abnormalities in Ph‐negative metaphases from patients with chronic myeloid leukemia (CML) treated with imatinib have been described in some cases. Trisomy 8 is the most frequent, but monosomy 7 has also been described. However, the association of these chromosomal alterations with myelodysplasia has been scarcely reported. We report the appearance of monosomy 7 in Ph‐negative cells, associated with severe dysplasia, in two patients with CML treated with imatinib, with a different outcome: one with a transient evolution and the other evolving to acute myeloid leukemia. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 83%

“…Ultrastructural study of the bone marrow showed abundant erythroblasts with normal morphology. The karyotype was 47,XY,þ8 [15]/46,XY,t(9;22)(q34;q11) [7]. Monosomy 7 was not detected by FISH either then or in two samples studied retrospectively: one prior to treatment with interferon and the other prior to the introduction of imatinib.…”

Section: Patientmentioning

confidence: 98%

Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia‐positive chronic myeloid leukemia: Two cases with a different outcome

et al. 2007

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“…The nuclei of the erythroid cells from our patients showed ultrastructural alterations compatible with dyserythropoiesis. Zarco et al (1991) observed slight nuclear dysplasia represented by the finding of "spongy" chromatin and binuclearity in the erythroblasts of a patient with congenital sideroblastic anemia. Dyserythropoietic changes were found in the cells from 5 out of 17 patients with hairy cell leukemia and coexisting sideroblastic anemia before drug administration (Zak et al, 1998).…”

Section: Discussionmentioning

confidence: 93%

Ultrastructural features of bone marrow cells from patients with acquired sideroblastic anemia

Djaldetti

Bergman

Salman

et al. 2004

Microscopy Res & Technique

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The ultrastructural findings of the bone marrow cells from 15 patients with acquired sideroblastic anemia are presented. The red cell precursors from all patients showed the presence of electron-dense material in the mitochondria, representing most probably iron deposits. A great number of these mitochondria were completely destroyed. The erythropoietic precursors from one of the patients showed markedly elongated mitochondria that measured up to 3 microm. In addition numerous cytoplasmic vacuoles were observed. The red cell precursors from 60% of the patients showed signs of dyserythropoiesis, such as incomplete nuclear division and nuclear distortion. The polymorphonuclears from 47% of the patients presented nuclear abnormalities expressed as nuclear bridges, appendices, and blebs. In addition, phagocytosis of red blood cells was observed. The results of the study underline the advantages of the transmission electron microscope examination in visualization of intricate alterations in hematopoietic cells that cannot be detected with a light microscope.

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“…In our case, some of them were more central, thus confusing with Howell‐Jolly bodies when present. They are believed to correspond to ferritin aggregates or isolated ferritin containing mitochondrias or phagosomes often surrounded by clumps of ribosomes and iron staining demonstrates hemosiderin precipitation . In our case, Pappenheimer bodies were only detectable into mitochondrias, grading from moderate ferruginous deposits to heavy compounds obscuring the inner crests (electron microscopy ×50 000, bottom).…”

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confidence: 51%

Multiple Pappenheimer bodies after splenectomy

Lesesve

Perrin

Guédenet

2012

European J of Haematology

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Ultrastructural Study of Erythrocytes Containing Pappenheimer Bodies in a Case of Congenital Sideroblastic Anaemia (Csa)

Cited by 9 publications

References 1 publication

Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia‐positive chronic myeloid leukemia: Two cases with a different outcome

Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia‐positive chronic myeloid leukemia: Two cases with a different outcome

Ultrastructural features of bone marrow cells from patients with acquired sideroblastic anemia

Multiple Pappenheimer bodies after splenectomy

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