Ultrastructural study of renal tubular damage induced by captopril in adult and fetal mice

Swelim, Hamdy Hamed; Sakr, Aleya A.

doi:10.21608/ejhm.2004.18154

Cited by 2 publications

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“…Also, Sánchez et al (2008) showed that administration of losartan during pregnancy resulted in severe renal abnormalities in both newborn and one-week-old animals. Moreover, Swelim and Sakr (2004) demonstrated that injection of captopril to pregnant mice resulted in degenerative changes in the renal tissue.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Ginger Extract on the Embryotoxicity and Nephrotoxicity Induced by Labetalol in Rat Fetuses

2023

JJBS

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Labetalol is a widely used antihypertensive drug, especially during pregnancy. However, its adverse effects on fetuses are unclear. This study aimed to evaluate the therapeutic role of ginger extract on embryonic and renal toxicity induced by labetalol in 20-day-old rat fetuses. Sixty pregnant rats were divided into four groups. Group I served as the control, group II received 200 mg/kg aqueous extract of ginger orally from the 6 th to the 15 th day of pregnancy, group III received 300 mg/kg labetalol orally over the same period, and group IV received labetalol and aqueous extract of ginger orally. At the end of the experiment, i.e. on the 20 th day, renal specimens from the rat fetuses were processed for light and electron microscopic examination and flow cytometric analysis of the cell cycle and apoptosis. Additionally, embryotoxicity and morphological parameters were assessed. The labetalol group showed a significant increase in embryo resorption and high growth retardation in the 20-day-old fetuses. Fetal kidneys displayed renal corpuscles with shrunken, narrowed urinary spaces, podocyte affection, tubular cell degeneration, hemorrhage, and hyalinization of tubules. Flow cytometric analysis demonstrated G0/G1 phase cell cycle arrest and a significant increase in apoptosis and necrosis. Administration of ginger with labetalol prevented most of these morphological, histological, and molecular changes. Prenatal exposure to labetalol caused embryonic and nephrotoxicity when administrated during the organogenesis phase. Ginger ameliorated these toxicities.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Ginger Extract on the Embryotoxicity and Nephrotoxicity Induced by Labetalol in Rat Fetuses

2023

JJBS

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Section: Discussionmentioning

confidence: 99%

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2023

JJBS

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Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell and tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscript that meets the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately one to two months after acceptance.

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Ultrastructural study of renal tubular damage induced by captopril in adult and fetal mice

Cited by 2 publications

References 0 publications

Therapeutic Potential of Ginger Extract on the Embryotoxicity and Nephrotoxicity Induced by Labetalol in Rat Fetuses

Therapeutic Potential of Ginger Extract on the Embryotoxicity and Nephrotoxicity Induced by Labetalol in Rat Fetuses

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