Ultrastructure and Clinicopathologic Correlation of Idiopathic Preretinal Macular Fibrosis

Bellhorn, Margaret B.; Friedman, Alan H.; Wise, George N.; Henkind, Paul

doi:10.1016/0002-9394(75)90608-x

Cited by 141 publications

(36 citation statements)

References 5 publications

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“…Interestingly, in some cells, IL-8 was co-expressed with NF-κB. Together with previous findings that endothelial cell is one of the main components of ERMs [4,5,6,7], NF-κB might be involved in the formation and development of neovascular component in PDR membranes.…”

Section: Discussionsupporting

confidence: 77%

“…However, recent studies have shown that NF-κB regulates the expression of angiogenic factors such as IL-8 in the endothelial cells and induces neovascularization that could lead to proliferative vitreoretinal disorders such as PDR [18,19,20]. In addition, since endothelial cell is one of the main components of ERMs [4,5,6,7], these findings suggest the possibility that NF-κB signalling is involved in the formation of PDR membranes.…”

Section: Conclusion/interpretationmentioning

confidence: 99%

“…The prevalence of ERMs in PDR is reported to be about 20% in Type 1 diabetes and about 5% in Type 2 diabetes [2,3]. Histopathological studies have shown that ERMs are composed of various cell types such as glial cells, fibroblasts and endothelial cells [4,5,6,7], but their pathogenic mechanisms are still unknown. In contrast, trophic factors and cytokines, such as basic fibroblast growth factor (bFGF), vascular endothelial cell growth factor (VEGF) and interleukin-8 (IL-8) were detected in vitreous fluid and ERM samples derived from PDR patients [8,9,10,11,12].…”

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confidence: 99%

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NF-?B in epiretinal membranes after human diabetic retinopathy

Mitamura

Harada

et al. 2003

Diabetologia

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Section: Discussionsupporting

confidence: 77%

Section: Conclusion/interpretationmentioning

confidence: 99%

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confidence: 99%

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NF-?B in epiretinal membranes after human diabetic retinopathy

Mitamura

Harada

et al. 2003

Diabetologia

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“…brane peeling have been applied to patients with progressive IF.M [6][7][8][9], Histopathologic studies on surgically removed specimens have been limited to conventional light-and elec tron-microscopic investigation [10][11][12][13][14][15]; de tails of the cellular and extracellular compo nents of IEMs have, therefore, not been de scribed well. Previous reports showed the presence of collagen fibrils, extracellular ma trix and proliferating cells in IEMs, but the types of the collagen fibrils and other extracel-lular matrices were not identified.…”

Section: Introductionmentioning

confidence: 99%

Histological and Immunohistochemical Study of Idiopathic Epiretinal Membrane

et al. 1995

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We used electron microscopy and light-microscopic immunohistochemistry of cellular and extracellular markers to characterize the cellular and extracellular components of 15 surgically resected idiopathic epiretinal membranes (IEMs). Ten specimens from the eyes with posterior vitreous detachment (PVD) consisted of inner limiting membrane, collagen layer and a flattened cell layer. Six out of the 10 specimens were also examined immunohistochemically, and fibronectin and type I, II, III and IV collagens were identified in a characteristic lamellar construct in the IEMs. On the other hand, 5 specimens obtained from the eyes without PVD consisted mainly of a thick layer of collagen fibrils with or without a flattened cell layer. Two of the 5 specimens were also examined immunohistochemically, and the collagen fibrils in the specimens were identified as type II collagen. Glial cells (glial fibrillary acidic protein-immunoreactive cells) were also identified in 3 specimens. These results indicate that there are some variations in the IEMs.

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“…Cells contain filaments of approximately 50 A in diameter present in bundles near cell membrane and associated with dense plaques (arrows). Specimen treated with myosin subfragment 1 ( 12,800).…”

Section: Light and Electron Microscopymentioning

confidence: 99%