Ultrastructure of Inhibited Parietal Cells in the Rat

Inhibition of acid formation by epidermal growth factor in the isolated rabbit gastric glands.

“…EGF may also differ from omeprazole regarding the action on the morphology of parietal cells. If given before secretary stimulation, EGF appears to prevent the transformation from resting to stimulated morphology (Gonzales, Garrido & Vial, 1981), whereas omeprazole does not seem to affect such a transition (Helander & Sundell, 1984).…”

Thioredoxin and thioredoxin reductase show function‐related changes in the gastric mucosa: immunohistochemical evidence

“…The gastric secretion was collected every 30min prior to and during the experiments. The volumes of the gastric secretion, pH and acidity were determined (Helander & Sundell 1984). At the end of the experiments the animals were anaesthetized and fixed by retrograde perfusion through the abdominal aorta with formalin, freshly prepared by alkaline hydrolysis of paraformaldehyde, in phosphate-buffered saline (PBS).…”

“…However, their mechanism of action is different, as are the morphological consequences of the two drugs. Atropine induces a return of the resting parietal cell morphology, while n o such effects are seen after the administration of benzimidazoles (Helander & Sundell 1984). Omeprazole apparently selectively inhibits acid secretion by interacting with the H',K' ATPase.…”

“…whether the cells were resting or actively secreting. Stimulation of parietal cells by either feeding or by a combined treatment with pentagastrin and carbachol induced marked morphological changes (Helander 1981, Helander & Sundell 1984~ as well as activation of the H+,K+ ATPase which catalyses the final step in the production of HCI. We were molecular-weight thioredoxin analogue, could reverse the potentiation of acid secretion observed after stimulation with oxidizing compounds.…”

“…Both atropine and omeprazole, a substituted benzimidazole, are established blockers of acid secretion (Larsson et a[. 1983, Helander & Sundell 1984). However, their mechanism of action is different, as are the morphological consequences of the two drugs.…”