Ultrastructure of intestinal and diffuse type gastric carcinoma

Nevalainen, Timo J.; Järvi, Osmo

doi:10.1002/path.1711220303

Cited by 54 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Table 2C, 11 minute gastric cancers were classified as papillary adenocarcinoma, 27 as well differentiated tubular adenocarcinoma, ten as moderately differentiated tubular adenocarcinoma, three as poorly differentiated adenocarcinoma and seven as signet-ring cell carcinoma. The cancers classified in the former three groups, totaling 48 (82.8%), were the intestinal type, and those in the latter two groups, totaling ten (17.2%), were the diffuse type, with marked prevalence of the former type.…”

Section: Histologic Typesmentioning

confidence: 92%

Minute gastric cancers less than 5 mm in diameter

Oohara

Tohma

Takezoe

et al. 1982

Cancer

View full text Add to dashboard Cite

Minute gastric cancers with maximum dimensions of less than 5 mm were studied clinicopathologically. There were 49 intramucosal cancers among 46 patients and nine submucosal cancers among nine patients. No lymph node metastasis was found. Macroscopically, eight (13.8%) were elevated, 12 (20.7%) were flat, and 38 (65.5%) were depressed. Most submucosal cancers were of the depressed type (8/9, 88.9%). Classification of cancers according to association with other large cancers into single group (22 cases) and multiple group (33 cases) revealed that (1) the majority of the minute gastric cancers (20/22, 90.9%) in the single group were the depressed type and (2) submucosal cancers in the single group were 8/22, accounting for 36.4%, a much higher incidence as compared with 1/36 (2.9%) in the multiple group. These facts indicate that gastric cancers should be detected when they are about 5 mm in maximum dimension and before they invade beyond the submucosal layer, especially in single and depressed type.

show abstract

Section: Histologic Typesmentioning

confidence: 92%

Minute gastric cancers less than 5 mm in diameter

Oohara

Tohma

Takezoe

et al. 1982

Cancer

View full text Add to dashboard Cite

show abstract

“…Nevertheless, it has long been recognized, including by Laurén, that intestinal type carcinoma in the stomach is unlike carcinoma of the colon, in that both intestinal and diffuse carcinomas of the stomach consist of intestinal and gastric types of cells [83,87,160,161], and intestinal type carcinoma is related to incomplete metaplasia, which has mixed intestinal and gastric features. The molecular changes re-enforce the view that intestinal type gastric carcinoma is quite All carcinomas 64 45 27 39 34 17 36 47 36 31 33 Expanding type 39 21 26 33 41 13 38 49 38 33 29 WD 24 14 17 25 58 13 53 54 36 36 28 PD 15 7 40 47 13 13 58 29 43 28 29 Infiltrative type 25 24 28 48 24 24 40 36 33 29 38 WD 17 12 29 59 12 30 53 17 58 25 17 PD 5 12 25 25 50 12 13 75 8 34 58 0, Absent; ϩ, weakly reactive; ϩϩ, strongly reactive; WD, well differentiated; PD, poorly differentiated.…”

Section: Molecular Alterations In Gastric Carcinomamentioning

confidence: 99%

Cellular and molecular pathology of gastric carcinoma and precursor lesions: A critical review

Ming

1998

Gastric Cancer

View full text Add to dashboard Cite

Abstract:The cellular and molecular pathology of gastric cancer and its precursors are reviewed and discussed. Gastric carcinogenesis is a multistep phenomenon, beginning with precancerous conditions. Among these, adenoma is a direct precursor, because of the dysplastic nature of its cells. However, gastric adenoma is relatively rare. Chronic atrophic gastritis (CAG) is the most common precancerous condition, in which intestinal metaplasia often occurs. Carcinoma develops in CAG through stages of hyperplasia and dysplasia involving both metaplastic and non-metaplastic glands. Molecular alterations, including replication error and p53 and APC gene mutation and aneuploidy have been found in some of these conditions, confirming their role in carcinogenesis. Carcinomas of the stomach are heterogeneous in cellular composition. Both intestinal and gastric types of cells are found in all types of tumors, indicating the unique characteristics of gastric cancer. Many molecular lesions have been found in gastric carcinomas. Basic changes involve replication errors, telomerase activity, and aberrant CD44 transcripts. Many other changes often show differences in the frequency of their occurrence between the two major histological types of gastric carcinoma: well differentiated versus poorly differentiated, or intestinal type versus diffuse type. The timing and frequency of these changes in the stomach differ from the timing and frequency in colonic carcinogeneis. Pathological evaluation remains reliable and meaningful, in basic research as well as clinical management. To obtain correlation with molecular alterations, the need for detailed pathologic classification of gastric carcinoma is recognized, taking into account its biologic behavior and grades of cell differentiation.The cellular and molecular pathology of gastric cancer and its precursors are reviewed and discussed. Gastric carcinomas are unique in their heterogeneity in both cellular composition and molecular changes.

show abstract

“…In cells containing abundant mucin the granules sometimes appeared to be fusing to form large, irregular pools of mucin. In two of the mucoid carcinomas, some of the granules contained an eccentrically situated electron dense core (Figure 5a), an appearance which has also been described in normal gastric mucosa (Nevalainen & Jarvi 1977). As in the latter, the core was unstained by the PA-Silver methenamine method (Nevalainen & Klemi 1976) ( Figure 5b).…”

Section: Mucoid Carcinoma Signet Ring Cell Carcinoma and Mucin-produmentioning

confidence: 61%

Mucin‐producing carcinomas of the breast: ultrastructural observations

et al. 1978

View full text Add to dashboard Cite

The ultrastructural characteristics of mucin production in mammary mucoid carcinoma, signet ring cell carcinoma (Harris, Wells & Vasudev 1978), papillary carcinoma and lobular carcinoma are compared. The mucin in lobular carcinoma is confined to intracytoplasmic lumina whereas it is present as membrane bound granules in the other three types, although intracytoplasmic lumina also occur in the latter. A possible origin of intracytoplasmic lumina from distended Golgi cisternae is proposed. Possibly, extracellular mucin acts as a mechanical barrier between tumour cells and lymphatics, thus explaining the good prognosis of typical mucoid carcinomas.

show abstract

Ultrastructure of intestinal and diffuse type gastric carcinoma

Cited by 54 publications

References 14 publications

Minute gastric cancers less than 5 mm in diameter

Minute gastric cancers less than 5 mm in diameter

Cellular and molecular pathology of gastric carcinoma and precursor lesions: A critical review

Mucin‐producing carcinomas of the breast: ultrastructural observations

Contact Info

Product

Resources

About