Ultrastructure of Intraradicular Dentin After Irrigation with BioPure MTAD. II. The Consequence of Obturation with an Epoxy Resin-Based Sealer

Denaturation Temperatures of Dentin Matrices. I. Effect of Demineralization and Dehydration

“…An even more pressing issue is the recent observation of demineralized collagen matrices on root canal walls (4,5) that are irrigated with 17% EDTA or BioPure MTAD (DentsplyTulsa, Tulsa, OK), a new, acidic antibacterial endodontic irrigant that consists of doxycycline hyclate, citric acid, and a detergent (32,33). As hydrated and briefly dehydrated demineralized dentin exhibited T d between 65.6°C to 112.9°C, thermal denaturation of demineralized root dentin collagen is Using the reciprocal°K regression characteristics, y ϭ 0.001096x ϩ 0.002034, R2 ϭ 0.5969, p ϭ 0.0417, the midpoint of this region at 18 molar ratio or water volume fraction of 0.584 gives a T max ϭ 101.9°C.…”

“…During cleaning and shaping, root canals are exposed to chelating agents such as ethylenediamine tetra-acetic acid (EDTA), and mild acids such as doxycycline and/or citric acid that can partially demineralize the surface of intraradicular dentin and create 2 to 10 m thick layers of partially demineralized collagen (3)(4)(5). Unless a deproteinizing agent such as sodium hypochlorite is employed as the final rinse, these denuded collagen fibrils may remain hydrated to a variable extent, depending on the method employed for drying the irrigated root canals (6,7).…”

Potential Iatrogenic Tetracycline Staining of Endodontically Treated Teeth via NaOCl/MTAD Irrigation: A Preliminary Report

“…Recently, an endodontic irrigant containing 3% doxycycline hyclate, 4.25% citric acid, and 0.5% polysorbate 80 detergent (2) is being commercialized as BioPure MTAD (Dentsply TulsaDental, Tulsa, OK) (3)(4)(5). Originally known as MTAD (6 -16), this irrigant is now recommended to be used as the final rinse for 5 min, after initial rinsing with a reduced concentration of 1.3% sodium hypochlorite (NaOCl) for a cumulated period of 20 min (7,(13)(14)(15)(16).…”

The effect of MTAD as a final root canal irrigants on the coronal bacterial leakage of obturated root canals

“…Ghoddusi et al also reported that the use of EDTA or MTAD produced more resistance to bacterial leakage than sodium hypochlorite 22) due to their superior smear layer removing ability. However Tay et al pointed out the potential risk of nanoleakage between hydrophobic root canal sealers and collapsed collagen matrices, which was confirmed in another study of them 23) . However, there have been very few studies comparing the leakage resistance of the root canals irrigated with MTAD (Biopure MTAD, Tulsa, OK, USA), EDTA and sodium hypochlorite.…”