Ultrastructure of normal, metaplastic, and abnormal human uterine cervix: Use of montages to study the topographical relationship of epithelial cells

Feldman, Dorothy; Romney, Seymour L.; Edgcomb, John; Valentine, Thomas

doi:10.1016/s0002-9378(84)90354-5

Cited by 13 publications

(15 citation statements)

References 18 publications

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“…Feldman et al. (5) noted that the basal cells varied considerably in size, even within the same specimen. They also recorded significant variation in the degree of increase in cell size above basal cell layer of human uterine cervix.…”

Section: Discussionmentioning

confidence: 99%

“…This denotes that the increase in cytoplasmic area was more than the increase in the nuclear area.There are very few studies quantifying cell morphometry especially for oral epithelium. Feldman et al (5) noted that the basal cells varied considerably in size, even within the same specimen. They also recorded significant variation in the degree of increase in cell size above basal cell layer of human uterine cervix.…”

Section: Discussionmentioning

confidence: 99%

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Morphometric computer-assisted image analysis of oral epithelial cells in normal epithelium and leukoplakia

Ragavendra

Rammanohar

Kasetty

2010

Journal of Oral Pathology &Amp; Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Morphometric computer-assisted image analysis of oral epithelial cells in normal epithelium and leukoplakia

Ragavendra

Rammanohar

Kasetty

2010

Journal of Oral Pathology &Amp; Medicine

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“…In the less mature layers of the tissue, different types of specialized contact areas of the cell membranes are observed, consisting of large protein molecules or networks of microfilaments effectively welding together the membranes of adjacent cells. In these layers, the extracellular volume is significantly larger than in the superficial layers (Hackemann et al 1968, Friedrich 1973, Feldman et al 1984.…”

Section: Normal Tissuementioning

confidence: 99%

A study of the morphological parameters of cervical squamous epithelium

et al. 2003

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Electrical impedance spectroscopy is a technique that has been investigated as a potential method for the diagnosis of epithelial carcinomas. Finite element modelling can provide an insight into the patterns of current flow in normal and pathological epithelium and hence aid in the process of probe design optimization. In order to develop a finite element model of the structure of normal and precancerous cervical squamous epithelium, it was first necessary to obtain the mean values and ranges of a number of morphological tissue parameters. The most important parameters in discriminating normal from neoplastic tissue were identified as being cell size and shape distribution, nuclear-to-cytoplasmic volume ratio and volume of extracellular space. A survey of the literature revealed an absence of reliable quantitative data for these parameters. We therefore present the results of our own basic image analysis on normal and pathological tissue sections, which we hope will be of use to other workers wishing to model cervical squamous epithelium, or other similar tissue structures.

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“…Hence tissues with different c ellular structures, including those associated with various tissue pathologies, will give rise to characteristic impedance spectra. In the case of precancerous changes in squamous or transitional epithelia, structural changes include loss of the layer of flattened cells close to the surface and an increase in the volume of extra-cellular space (Feldman et al 1984), (White et al 1984).…”

Section: Introductionmentioning

confidence: 99%

Modelling the electrical properties of bladder tissue—quantifying impedance changes due to inflammation and oedema

et al. 2005

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Electrical Impedance Spectroscopy has been developed as a potential method for the diagnosis of carcinoma in epithelial tissues. An understanding of the influence of structural changes in the tissue on the properties measured using this technique is essential for interpreting measured data and optimisation of probe design. In contrast to other tissue types, carcinoma in Situ of the bladder gives rise to an increase in electrical impedance over the kHz-MHz frequency range in comparison to normal tissue. Finite element models of the • A Keshtkar,is now at: Medical Physics Department, Faculty of Medicine, Tabriz University of Medical Sciences,Tabriz-Iran urothelium and the underlying superficial lamina propria have been constructed and solved in order to ascertain the influence of structural changes associated with malignancy, oedema and inflammation on the measured electrical properties of the tissue. Sensitivity analysis of results from a composite tissue model suggests that the increase in lymphocyte density in the lamina propria associated with an inflammatory response to the infiltration of urine into the tissue may explain these unusual electrical properties.

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Ultrastructure of normal, metaplastic, and abnormal human uterine cervix: Use of montages to study the topographical relationship of epithelial cells

Cited by 13 publications

References 18 publications

Morphometric computer-assisted image analysis of oral epithelial cells in normal epithelium and leukoplakia

Morphometric computer-assisted image analysis of oral epithelial cells in normal epithelium and leukoplakia

A study of the morphological parameters of cervical squamous epithelium

Modelling the electrical properties of bladder tissue—quantifying impedance changes due to inflammation and oedema

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