Ultrastructure of peritubular tissue in association with tubular hyalinization in human testis

Haider, Syed G.; Talati, Jamsheer; Servos, Gisela

doi:10.1054/tice.1999.0005

Cited by 24 publications

(15 citation statements)

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“…We found a decreased tubular diameter and a varying degree of peritubular fibrosis and tubular hyalinization in the testicular biopsies of all our patients. Tubular hyalinization is a general finding in end-stage testicular damage and is caused by massive deposition of collagen fibers inside the seminiferous tubules (22,23). In our patients, tubular hyalinization could have been caused by chronic obstruction of the seminiferous tubules.…”

Section: Discussionmentioning

confidence: 59%

Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage

Grinten

Otten

Hermus

et al. 2008

Fertility and Sterility

122

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Section: Discussionmentioning

confidence: 59%

Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage

Grinten

Otten

Hermus

et al. 2008

Fertility and Sterility

122

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“…The enlargement of this layer has been associated with altered myoid cells that produce tubular fibrosis [Santamaría et al, 1995;Zarnescu and Zamfirescu, 2006]. According to Söderstrom [1986], this alteration occurs during testicular hyalinization, a pathological process during which the myoid cells are disorganized, and leads to an elliptical/ovoid shape and nuclear fragmentation [Haider et al, 1999]. Thus, the enlargement of the collagen-rich layer seems to be related to a functional disorder in the collagen I synthesis process of the myoid cells.…”

Section: Discussionmentioning

confidence: 99%

Immunosuppressant Prograf® (Tacrolimus) Induces Histopathological Disorders in the Peritubular Tissue of Rat Testes

Caneguim

Cerri

Spolidório

et al. 2011

Cells Tissues Organs

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Treatment with tacrolimus (FK-506) has been shown to induce a significant decrease in the number of spermatocytes, spermatids, and Sertoli cells. Regarding the importance of the peritubular tissue for the maintenance of Sertoli cells, the integrity of the cellular and extracellular components of the peritubular tissue was evaluated in adult rats that were treated with 1 mg/kg/day of FK-506 for 30 and 60 days. Testicular sections were used for a quantitative analysis of the peritubular cells (PCs) and were submitted to the PAS method. Paraffin sections were submitted to the TUNEL method and to immunohistochemistry for the detection of caspase-3. Several testicular fragments were analyzed under a transmission electron microscope (TEM). A weak PAS reaction was noted in the peritubular tissue of the tacrolimus-treated animals. Next to the damaged peritubular tissue, the Sertoli cell nuclei were absent or dislocated from the basement membrane. In the treated animals, the number of PCs decreased significantly compared to the control animals, and these cells showed apoptotic features, were TUNEL positive, and were caspase-3 immunolabeled. Using the TEM, apoptosis was confirmed in myoid cells; moreover, the thickness and undulation of the basal laminae and an enlargement of the collagen I layer adjacent to the myoid cells was observed. Long-term treatment with the immunosuppressor induced peritubular myoid cell death by apoptosis and disarrangement of the peritubular extracellular layers. Future studies are necessary to confirm whether the structural alterations in the seminiferous epithelium are related to the effect of FK-506 on peritubular tissue.

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“…The adverse effects of smoking are thought to be partly mediated by the induction of a hypoxic state; carboxyhaemoglobin concentrations in the blood were increased in women smokers [21]. The hormonal regulation of testicular function in aged testes is compatible with a relatively decreased oxygen supply [22]. These ®ndings imply that vascular insuf®ciency in nicotine toxicity may be one of the possible causes of the structural changes in seminiferous tubuli and peritubular tissues.…”

Section: Discussionmentioning

confidence: 99%

Nicotine toxicity to the ultrastructure of the testis in rats

Aydos¹,

Güven²,

Can³

et al. 2001

BJU International

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Objective To investigate the in¯uence of nicotine exposure on the ultrastructure of the rat testis. Materials and methods Twenty rats were injected with nicotine at a dose of 0.4 mg/100 g body weight daily for 3 months; a group of 20 control rats matched for weight and age were injected with saline only for the same duration. The testes were then harvested and examined by transmission electron microscopy. Results Rats given nicotine showed: thickening of the tunica propria, caused by an increase in the collagen ®bres under the irregular basal lamina; degeneration of junctional specializations between the Sertoli cells, with malformed nuclei showing condensed chromatin; Sertoli cells with numerous polymorphic mitochondria with irregular cristae and an electron-dense matrix. The germ cells were degenerated, spermatids retained excess cytoplasm and accumulated electrondense lipid droplets in the cytoplasm. The acrosomes were irregular and abnormally con®gured. Conclusion There were ultrastructural alterations in rats exposed to nicotine that could be attributed to the detrimental effects of nicotine on germ cells, peritubular structures and Sertoli cells.

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Ultrastructure of peritubular tissue in association with tubular hyalinization in human testis

Cited by 24 publications

References 0 publications

Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage

Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage

Immunosuppressant Prograf® (Tacrolimus) Induces Histopathological Disorders in the Peritubular Tissue of Rat Testes

Nicotine toxicity to the ultrastructure of the testis in rats

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