Ultrastructure of pigmented villonodular synovitis

Ghadially, F. N.; Lalonde, J‐M. A.; Dick, C.

doi:10.1002/path.1711270104

Cited by 38 publications

(16 citation statements)

References 16 publications

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“…The presence of discrete hotspots corresponding to gold in macrophages treated with Au NPs is consistent with earlier work that used transmission electron microscopy to show that Au NPs were packaged into endosomes and then lysosomes following entry into the cells [51]. It is likely that the same events occur in macrophages following treatment with aurothiomalate [13,14]. Fig.…”

Section: Cellular Au Distributionsupporting

confidence: 88%

“…Several metabolites of the gold(I) complexes have been identified, including [Au(CN) 2 ] -, Au(III) complexes and Au(0) [7]. It has also been shown that cells sequester gold into lysosomal bodies termed aurosomes [13,14]. X-ray absorption near edge spectroscopy (XANES) showed that aurosomal gold in the tissues of rats treated with aurothiomalate or [AuCl 4 ] -is present in the +1 oxidation state, while extended X-ray absorption fine structure (EXAFS) spectroscopy showed that the metal was bound to two sulfur atoms [15].…”

Section: Introductionmentioning

confidence: 99%

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An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase

James

Sluyter

et al. 2015

Journal of Inorganic Biochemistry

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Section: Cellular Au Distributionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase

James

Sluyter

et al. 2015

Journal of Inorganic Biochemistry

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“…Furthermore. ultrastructural examination in PVNS has not revealed any evidence of collagen phagocytosis (8).…”

Section: Discussionmentioning

confidence: 90%

A unique presentation of multicentric reticulohistiocytosis in pregnancy

Conaghan

Miller

Dowling

et al. 1993

Arthritis & Rheumatism

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We describe a patient with multicentric reticulohistiocytosis who presented, during the second trimester of pregnancy, with symmetric polyarthritis, marked erythematous, pulsatile synovial swelling of the distal interphalangeal joints of both hands, and widespread telangiectasias. She did not have the typical skin manifestations of multicentric reticulohistiocytosis. The erythema and pulsatility of the synovial swellings of the distal interphalangeal joints resolved after delivery, but she continued to have widespread active synovitis, which did not resolve until treatment with low-dose oral methotrexate was instituted. delivery. The destructive polyarthritis persisted after pregnancy, but she had an excellent, early response to treatment with low-dose oral methotrexate. CASE REPORTThe patient. a 3.5-year-old East Timorese woman, presented to us in September I990 at 24 weeks gestation, with a I-month history of bleeding gums and facial rash, and a 3-month history of stiffness in the small joints ofthe hands and both knees and fatigue. A ganglion had been excised from the left wrist at another hospital 4 months before conception. Past obstetric history included I first-trimester spontaneous abortion and I successful pregnancy complicated by third-trimester gestational diabetes. She had no rash or joint symptoms during the previous pregnancies. There was no previous personal or family history to suggest a bleeding diathcsis.On physical examination at presentation. there were prominent telangiectasias over her face. oral mucosa and tongue, upper chest, and arms. She had marked erythematous synovial swelling over the DIP joints of both hands ( Figure I ) . On palpation. the synovial swellings were found to be pulsatile. and pulsed with the heart beat. There was mild tenderness over the joint lines. Effusions o f the proximal interphalangeal (PIP) joints of both hands and both knees were present, but without associated erythema or pulsation. There was a reducible flexion deformity of the right fifth DIP joint. There were no cutaneous nodular lesions. A soft systolic flow murmur was present, and uterine fundus height was compatible with pregnancy duration.Initial laboratory investigations revealed a mild

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“…It is observed in most of the cases among patients between 20 and 50 years of age, with slightly higher prevalence among females (4,6) .…”

Section: Introductionmentioning

confidence: 98%