Ultrastructure of Rat Adrenal Glands with Chronic Renal Insufficiency Following Placental Cryoextract Therapy in the Course of RAAS Medicated Blocking

Репин, М В; Marchenko, Larysa; Говоруха, Т. П.; Strona, V. I.; Chizh, Yu. A.

doi:10.26693/jmbs04.06.349

Cited by 2 publications

References 8 publications

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Cold in Biology and Medicine: state of the art and perspectives

Edited by Professor O. Yu. Petrenko

2023

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The monograph highlights the main development stages of the Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine. It provides an infor-mation about the major achievements in cryobiology and cryomedicine, fundamental and applied researches being of a priority value. Certain scientific directions formed during this time and coi-ned as the separate scientific schools have been specially empasized. Particular attention is paid to the basic aspects of cryopreservation of biological objects, mechanisms of cold adaptation of biolo-gical systems, modern methodical approaches to cryopreservation of genetic resources and stem cells of various origins, development of low-temperature techniques in modern biology and regenerative medicine. The monograph is intended to biologists and medical specialists, biology and medicine students, those having an interest in modern cryotechniques in biology and medicine.

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Cold in Biology and Medicine: state of the art and perspectives

Edited by Professor O. Yu. Petrenko

2023

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Placental Cryoextract and Renin-Angiotensin-Aldosterone System Blockade Mitigate Renal Failure in Rats

Репин

Chyzh

Marchenko

et al. 2021

Probl Cryobiol Cryomed

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Here, we have studied the impact of administration of rat placental cryoextract (PCE), drug blockade of the renin-angiotensin-aldosterone system (RAAS) with enalapril and spironolactone and their combination on the rat kidney tissue structure and excretory function at different stages of chronic renal failure (CRF) development using the glycerol model. In 3 weeks after glycerol introduction, the animals from all the groups showed low values of glomerular filtration rate, impaired blood flow in renal cortex, tubular epithelial dystrophy, inflammation and edema of interstitium, indicating the onset of CRF development. Tubulo-interstitial nephritis and nephrosclerosis were dominated in untreated rats 16 weeks later. The use of RAAS drug blockade, as well as a comprehensive therapy with RAAS blockers and placental cryoextract stopped the inflammatory processes in renal tissue, restored blood circulation and normalized excretory function, which persisted for up to 16 weeks of observation.

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Ultrastructure of Rat Adrenal Glands with Chronic Renal Insufficiency Following Placental Cryoextract Therapy in the Course of RAAS Medicated Blocking

Cited by 2 publications

References 8 publications

Cold in Biology and Medicine: state of the art and perspectives

Cold in Biology and Medicine: state of the art and perspectives

Placental Cryoextract and Renin-Angiotensin-Aldosterone System Blockade Mitigate Renal Failure in Rats

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