Ultrastructure of the hyperhidrotic eccrine sweat gland

Bovell, DL; Clunes, Mark T.; Elder, H. Y.; Milsom, J.; Jenkinson, D. McEwan

doi:10.1046/j.1365-2133.2001.04351.x

Cited by 62 publications

(43 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The same was also true for the ductal and secretory coil measurements of apocrine glands between the two groups. These data contradict previous work reporting an enlarged lumen in hyperhidrotic eccrine glands (7).…”

Section: Resultscontrasting

confidence: 57%

“…The role of primary, human, tissue-derived MCs in the process of tumor progression has not been defined yet (7)(8)(9)(10). In this study, we have developed a co-culture system of various types of cutaneous malignant cells with primary human skin-derived MCs.…”

Section: Questions Addressedmentioning

confidence: 99%

“…Eccrine gland hypertrophy has been suggested as a possible reason for excessive sweating in hyperhidrosis; (2) however, this seems unlikely as changes in gland size have not been observed previously (7,8). The existence in the human axilla of a third type of sweat gland, the 'apoeccrine' gland, reputedly with morphological characteristics of both apocrine and eccrine glands has been cited as a potential cause for axillary hyperhidrosis (1,9).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

Bovell

MacDonald

Meyer

et al. 2011

Experimental Dermatology

View full text Add to dashboard Cite

Effect of T injection and EGCG on T and DHT concentrations in serum and hairAnalysis using LC-MS ⁄ MS on serum and hair samples was performed to determine the difference in the T and DHT concentrations in each group. We found no difference in the T and DHT concentrations between the T-injected and T + EGCG groups (unpublished data). ConclusionWe report the first in vivo experiment showing the influence of T injection and EGCG on hair follicles. Our results suggest that T injection in a B6CBAF1 ⁄ j mouse model induces hair loss by apoptosis of hair follicles rather than through the androgen metabolic pathway. Furthermore, it was shown that EGCG can prevent hair loss by reducing T-induced apoptosis of follicular epithelial cells and provoke hair re-growth after epilation.The best animal model of androgen-induced alopecia is the stump-tailed macaque, but because of its large size and high cost, researchers favour a more easily handled murine model (19). The B6CBAF1 ⁄ j mice used in this study were first introduced by Matias et al. (17) as a T-induced androgenic alopecia mice model. The B6CBAF1 ⁄ j mouse is not a perfect androgen-induced alopecia model in that androgen is needed to be given continuously, and once androgen supplementation ceases, the mouse regains its hair within 3 months. Because B6CBAF1 ⁄ j mice are convenient, costeffective and suitable with respect to the time course of results, B6CBAF1 ⁄ j mice were used in this study.Even though there was no difference in the expression of 17b-and 3b-HSD between the T-injected and T + EGCG groups, we cannot exclude the possibility of the effect of EGCG on androgen metabolism of hair follicles because EGCG application down-regulated T-induced AR expression of hair follicles. To resolve this question, further functional in vitro studies using hair follicle culture will be needed.From our study, we propose topical EGCG as a promising therapeutic tool in the management of androgen-related hair loss. Acknowledgements Conflict of interestThe authors declare no conflict of interests. Supporting InformationAdditional Supporting Information may be found in the online version of this article: Figure S1. Immunohistochemical histology of the upper dorsal skin stained with androgen receptor (a-f). Table S1. Number of hair follicles counted by Folliscope Ò on day16 after epilation. Table S2. Comparison of the intensity of the apoptosis by TUNEL staining and immunohistochemical staining of androgen receptor of the treated groups. Topical application of 10% EGCG (a), testosterone (T)'s vehicle injection (b), T injection (c), T injection + topical application of EGCG vehicle (ethanol)) (d), T injection + topical application of 10% cyproterone acetate (e), and T injection + topical application of EGCG (f) (·400).Appendix S1. Materials and methods. Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the ...

show abstract

Section: Resultscontrasting

confidence: 57%

Section: Questions Addressedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

Bovell

MacDonald

Meyer

et al. 2011

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…Die ekkrinen Schweißdrü-sen (Glandulae sudoriferae eccrinae) kommen in größerer Zahl nur beim Menschen und bei höher entwickelten Affen vor. Sie sind die physiogenetisch jüngeren, differenzierteren Schweißdrüsen und ersetzen die apokrinen Drüsen beim Menschen praktisch an der gesamten Hautoberfläche [2]. Auf der menschlichen Haut befinden sich etwa 2-5 Mio.…”

Section: Anatomie Und Physiologie Der Schweißdrüsenunclassified

Liposuktionskürettage versus Botox® bei axillärer Hyperhidrosis

Ottomann

Blazek

Hartmann

et al. 2007

Chirurg

View full text Add to dashboard Cite

show abstract

“…As glândulas écrinas nos indivíduos portadores de hiperidrose apresentam-se hipertrofiadas à microscopia óptica com sinais claros de hiperatividade, podendo chegar a oito vezes seu tamanho normal, e com todas as células morfologicamente intactas, porém aumentadas de tamanho 12 .…”

Section: A Hiperidroseunclassified

Comparação dos resultados obtidos no tratamento da hiperidrose palmar pela simpatectomia torácica videotoracoscópica nos níveis de desnervação: T2 e T3

Yazbek¹

View full text Add to dashboard Cite

©reprodução autorizada pelo autor Yazbek, Guilherme Comparação dos resultados obtidos no tratamento da hiperidrose palmar pela simpatectomia torácica videotoracoscópica nos níveis de desnervação T2 e T3 / Guilherme Yazbek. iii DedicatóriaAo meu pai, Dr. Amilcar, exemplo de dedicação, competência e amor pela medicina; modelo para minha formação e que sempre me apoiou em novas conquistas.À minha esposa, Edith, por seu apoio, paciência, carinho e pela felicidade de tê-la a meu lado, sem a qual seria impossível a realização desta pesquisa.À minha mãe, Janete, por seu sacrifício, dedicação e amor na criação dos filhos.Aos meus irmãos e sobrinhos e especificamente à minha irmã, Lais, exemplar médica ginecologista, modelo de dedicação aos pacientes, que sempre me motivou no exercício da profissão apesar das dificuldades da medicina atual. video-assisted thoracoscopic sympathectomy at the T2 or T3 ganglion level. They were followed up for a mean of 20 months and were evaluated regarding their degree of improvement of palmar hyperhidrosis; incidence and severity of compensatory hyperhidrosis and its evolution over time; and quality of life. RESULTS: Fifty-nine cases presented resolution of the palmar hyperhidrosis. One case of therapeutic failure occurred in the T3 group. Most of the patients presented an improvement in plantar hyperhidrosis, without any difference between the groups. Twenty months later, all of the patients in both groups presented some degree of compensatory hyperhidrosis, but with less severity in the T3 group (p = 0.007). Compensatory hyperhidrosis developed in most patients during the first month after the operation, with incidence and severity that remained stable over time. An improvement in quality of life was seen, starting from the first postoperative evaluation, but without any difference between the groups. This was maintained until the end of the follow-up. CONCLUSION: Both techniques were effective for treating palmar hyperhidrosis. The most frequent complication was compensatory hyperhidrosis, which presented stable incidence and severity over the study period. Sympathectomy at the T3 level presented compensatory hyperhidrosis of less severity. Nevertheless, the improvement in quality of life was similar between the groups.Descriptors: hyperhidrosis, sympathectomy, quality of life.

show abstract

Ultrastructure of the hyperhidrotic eccrine sweat gland

Abstract: The present finding of the absence of structural defects in the glands indicates that future studies should concentrate on the investigation of neurohumoral or secretory cell metabolic abnormalities.

Cited by 62 publications

References 17 publications

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

Liposuktionskürettage versus Botox® bei axillärer Hyperhidrosis

Comparação dos resultados obtidos no tratamento da hiperidrose palmar pela simpatectomia torácica videotoracoscópica nos níveis de desnervação: T2 e T3

Contact Info

Product

Resources

About