Ultrastructure of the nucleus of human sertoli cells in normal and pathological testes

Sertoli cell nuclear changes in human testicular biopsies as revealed by three dimensional reconstruction

“…This value agrees most with the data reported by Russell et al (1990), which may be due to the same procedure of tissue processing. Data presented here revealed no stage-specific differences of the Sertoli cell nuclei in respect of volume and surface, confirming light and electron microscopical data reported by Schulze (1974), and Bustos-Obregon & Esponda (1974).…”

“…Similar stage-specific alterations of Sertoli cell morphology have not yet been verified for the human (Breucker et aL, 1985). Although the shape and position of Sertoli cell nuclei seem to vary according to the stages of spermatogenic cycle (Elftman, 1950), such changes could not be determined for monkeys (Dym, 1973) or humans (Bustos-Obregon & Esponda, 1974;Schulze, 1974). However, numerous cytological alterations, including nuclear morphology, are described for human Sertoli cells associated with spermatogenetic impairment.…”

“…For example, by producing proteins such as androgen binding protein, establishing the blood-testis barrier, and secreting intratubular fluid (for review see Fawcett, 1975;Waites & Gladwell, 1982;De Kretser & Kerr, 1988). Although the shape and position of Sertoli cell nuclei seem to vary according to the stages of spermatogenic cycle (Elftman, 1950), such changes could not be determined for monkeys (Dym, 1973) or humans (Bustos-Obregon & Esponda, 1974;Schulze, 1974). Similar stage-specific alterations of Sertoli cell morphology have not yet been verified for the human (Breucker et aL, 1985).…”

Ultrastructural study of the coiled body and a new inclusion, the “mykaryon”, in the nucleus of the adult rat sertoli cell

“…The architecture of the Sertoli cell nucleus has been examined in many mammalian species and is well characterized for man (Bustos-Obreg6n and Esponda, 1974;Schulze, 1974Schulze, , 1979de Kretser and Burger, 1972;Nistal et al, 1982;Devictor et al, 1984; one another by less-opaque interstitial spaces. The labeled coil is irregular in outline, with a narrow stalk (arrow) branching to a more evenly contoured projection.…”

Perspectives in Pediatric Pathology, Chapter 3. Testicular Development from Birth to Puberty: Systematic Evaluation of the Prepubertal Testis

“…The Sertoli cell nucleus becomes enlarged with irregular, indented outlines. The chromatin becomes loose, and the nucleolus acquires a tripartite structure [61]. The most prominent cytoplasmic changes include smooth and rough endoplasmic reticulum, elongated mitochondria with longitudinal cristae, increase in lysosomes and lipid droplets, and the appearance of annulate lamellae and Charcot-Böttcher crystals.…”