Ultrastructure of the thymus in diabetes mellitus and starvation

Abstract

This study demonstrates that the thymus was affected ultrastructurally by diabetes and concomitant fasting, and insulin treatment can reverse these changes.

Thymic microenvironmental alterations in experimentally induced diabetes

“…diseases, mainly infectious diseases (Savino, 2006;Andrade et al, 2008). In other experimental diabetes models, similar results were also found (Barreto et al, 2005;Elmas et al, 2008).…”

“…The effect of diabetes on the immune system, particularly affecting the thymus gland, has been investigated by many researchers (Barreto et al, 2005;Savino et al, 2007;Elmas et al, 2008;Park et al, 2008). Recently, we have showed enhanced deposition of fibronectin, laminin, and CXCL12 in the thymus from NOD mouse (Mendes-da-Cruz et al, 2008).…”

“…These authors have observed multiple cell migration abnormalities in NOD thymocytes. Yet, other authors have demonstrated that the thymus is ultra-structurally affected by diabetes and concomitant fasting, and that insulin treatment is able to reverse these pathologic changes (Elmas et al, 2008).…”

Lipids in the Bone Marrow: An Evolving Perspective

“…Why would marrow adipocytes store lipids in states of acute or chronic calorie deficiency? One possibility is that this represents a protective mechanism permitting the marrow to have readily available substrate to maintain hematopoiesis and bone remodeling in a manner analogous to what has been reported with lymph tissue during chronic starvation in animals (Elmas et al, 2008;Nelson and Demas, 1996). Another hypothesis is that marrow fat fills the space previously occupied by skeletal tissue because of a lineage shift between pre-adipocytes and pre-osteoblasts due to lack of substrate availability.…”

Aterações no microambiente timico frente a diferentes agentes indutores de atrofia

“…A literatura mostra que doenças metabólicas como o diabetes também promovem a atrofia do órgão, caracterizada por alterações ultra-estruturais com desorganização córtico-medular e alta incidência de apoptose no córtex subcapsular (ELMAS, et al, 2008).…”