Ultrastructure of Tumors Induced in Mice by Moloney and Harvey Strains of Murine Sarcoma Virus2

Papadimitriou, J. M.; McCully, D. J.; Simons, P. J.

doi:10.1093/jnci/53.3.829

Cited by 6 publications

(1 citation statement)

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“…Moloney murine sarcoma virus rapidly induces various types of sarcomas in mice [2,15]. But the induction of osteosarcomas by M-MSV has been re- 7 6 12 123 19 9 7 122 10 9 16 232 30 16 12 440 95 16 8 472 116 16 10 684 68 16 13 335 60 42 13 360 39 42 7 402 68 Untreated control 6 128 35 8 148 11 4 153 25 8 137 23 8 100 9 Cumulative analysis 6 25 118 25 16 43 490 45 Control 34 131 45 ported only in neonatal rats, when virus was introduced into the medullary cavity of tibia [1,6,7].…”

Section: Discussionmentioning

confidence: 99%

Virally induced periosteal osteogensis in mice

Włodarski¹,

Kobus²,

Łuczak³

et al. 1981

Calcif Tissue Int

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Inoculation of Moloney murine sarcoma virus (M-MSV) into shank muscles of adult NMRI mice resulted in localized sarcoma and periosteal membrane proliferation with subsequent periosteal bone formation. Newly formed bone arose from outer surface of shank bones. Two weeks after M-MSV inoculation the width of bone cortex increased nearly 4 times. The spaces between newly formed bone ossicles were filled with bone marrow. In the later stages these bone marrow cavities were merged with medullar cavities. No extraskeletal bone formation was observed. The regression of M-MSV-induced sarcomas coincides with cessation of the proliferation of bone therefore allowing the maturation and rebuilding of bone. Newly formed bone was not resorbed during a 6-month observation period.

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Section: Discussionmentioning

confidence: 99%

Virally induced periosteal osteogensis in mice

Włodarski¹,

Kobus²,

Łuczak³

et al. 1981

Calcif Tissue Int

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Murine sarcoma virus (msv)‐induced tumors in mice. I. Distribution of msv‐immune cytolytic t lymphocytes in vivo

Plata¹,

Sordat²

1977

Intl Journal of Cancer

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Quantitative studies using a 51Cr release assay were performed to analyse the time-course of appearance and specificity of cytolytic cells in C57Bl/6 mice inoculated with Moloney murine sarcoma virus (MSV). Various lymphoid organs were studied including spleen, mesenteric lymph nodes (MLN), lymph nodes regional to the MSV-induced tumor (RLN), and peripheral blood. Furthermore, the kinetics of appearance of cytolytic cells within the MSV-induced tumor was determined. In agreement with previous studied, it was found that cytolytic T lymphocytes (CTL) specific for MSV-associated antigens were present among the cells extracted from the tumor and from the lymphoid organs. However, differences in the kinetics of CTL activity could be documented: lymphoid cells from spleen, RLN and peripheral blood showed peak activity at the time of maximum tumor diameter, while intratumoral cells showed peak activity at the onset of tumor regression. MLN cells showed cytolytic activity only when tumor regression had begun. Naturally cytotoxic cell populations of thymus-independent origin, present in normal control mice, were also detected in MSV-infected mice.

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Dynamics of Cell-Mediated Immune Response

Lefever

1980

Dynamics of Synergetic Systems

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Ultrastructure of Tumors Induced in Mice by Moloney and Harvey Strains of Murine Sarcoma Virus2

Cited by 6 publications

References 0 publications

Virally induced periosteal osteogensis in mice

Virally induced periosteal osteogensis in mice

Murine sarcoma virus (msv)‐induced tumors in mice. I. Distribution of msv‐immune cytolytic t lymphocytes in vivo

Dynamics of Cell-Mediated Immune Response

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