Ultrastrukturelle Aspekte zur Pathogenese der Desoxycholat-Pankreatitis

Abstract

After intraperitoneal application of desoxycholate in cells of exocrine pancreas, ultrastructural alterations are observed. Initial changes are seen in mitochondria and focal parts of the endoplasmic reticulum. In later experimental stages there is sizable increase in the extent of the initially focal degradations, in such a way that great areas of the cytoplasm are involved. It is remarkable to note, that there are no indications about any disturbance in the synthesis and excretion of zymogen granules. The described morphological alterations will be discussed as conceivably being caused primarily by an irritation in the lipoid metabolism of the membrane.

Hyperbaric oxygen-induced changes in bacterial translocation and acinar ultrastructure in rat acute necrotizing pancreatitis

“…The ultrastructural injury scores were significantly lower in rats with ANP treated with HBO than in the untreated rats. Zymogen granules, which are known to be resistant to the toxic effects of bile salts, 37 were normal in both treated and untreated animals. Ultrastructural scores, reflecting organelle recovery, were correlated with histological improvement.…”

Inhibitory effect of various cytostatics and cycloheximide on acute experimental pancreatitis in rats.

“…Several methods of producing acute experimental pancreatitis are known-for instance, perfusing the bile ducts (Elliott et al, 1958;Beck et al, 1964), interstitially administering different compounds (Keith et al, 1958;Waterman et al, 1969), or by the action of various stimuli or inducers (Bawnik et al, 1974;Schiller et al, 1974;Backwinkel et al, 1975;Lombardi et al, 1975). In the present study 90 male rats (Wistar, 250-300 g) were kept on a standard diet and separated into several groups.…”