Ultrastrukturelle Veränderungen der Nasenschleimhaut bei primärer ziliarer Dyskinesie

Abstract

Primary ciliary dyskinesia syndrome (PCD) is a rare, autosomal receive disorder. Kartagener's syndrome is a subgroup of the PCD with situs inversus, bronchiectasis, and sinusitis. The symptoms results from an abnormal ultrastructural morphology of the cilia such as absence of dynein arms and other changes. As a consequence ciliary motility is disturbed. A 25-year-old man was examined because he suffered from recurrent severe pneumonia and Aspergillus infections of the lungs. On electron micrographs, ciliary abnormalities including deficiency of inner and outer dynein arms, dysmorphic outer dynein arms, and disorientation of the cilia were demonstrated. The diagnosis of PCD requires electron-microscopic investigations of the ciliated mucosa. Special attention should be given to ultrastructural changes of nasal or bronchial mucosa if a young patient suffers from recurrent severe respiratory infections.

Dexpanthenol—Nasenspray vs. Nasensalbe

“…Als Test zur Prüfung der Funktion der Nasenschleimhaut wird in vivo am häufigs-ten der Saccharintest zur Bestimmung der mukoziliaren Transportzeit eingesetzt [1,9,22].Er gilt als hinreichend validiert [28]. Hier wurde er nach den Empfehlungen von Deitmer eingesetzt [10].…”