Ultrathin PEGylated W<sub>18</sub>O<sub>49</sub> Nanowires as a New 980 nm‐Laser‐Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo

Chen, Zhigang; Wang, Qian; Wang, Huanli; Zhang, Lisha; Song, Guohe; Song, Linlin; Hu, Junqing; Wang, Hongzhi; Liu, Jianshe; Zhu, Meifang; Zhao, Dongyuan

doi:10.1002/adma.201204616

Cited by 375 publications

(268 citation statements)

References 45 publications

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“…[ 8,11 ] Photothermal therapy (PTT) usually employs near-infrared (NIR) light-absorbing agents to generate heat from optical energy, leading to thermal ablation of cancer cells. [ 12 ] In the past decade, a large number of NIR-absorbing nanomaterials, such as different gold nanostructures, [ 13 ] carbon-based nanomaterials, [ 12,14 ] palladium nanosheets, [ 15 ] copper sulfi de nanoparticles, [ 16 ] tungsten oxide nanowires, [ 17 ] as well as various organic polymers and nanoparticles, [ 18 ] have been widely explored by many research groups including ours as photothermal agents for PTT ablation of cancer in vitro and in vivo. In a recent work, Chou et al for the fi rst time demonstrated the possibility of using as-made MoS 2 nanosheets as a new NIR absorbing agent for in vitro-photothermal-killing of cancer cells in vitro at the cell culture level.…”

Section: Doi: 101002/adma201304497mentioning

confidence: 99%

PEGylated WS₂ Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

et al. 2013

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A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.

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Section: Doi: 101002/adma201304497mentioning

confidence: 99%

PEGylated WS₂ Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

et al. 2013

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“…[57][58][59][60] Chen et al 58 and other groups reported the preparation of ultrathin PEGylated W 18 O 49 nanowires through a solvothermal reaction of a WCl 6 precursor in a mixture of PEG (M w = 400 Da) and ethanol solutions. A 980 nm wavelength laser was used to instantly convert photoenergy into thermal energy at a safe power density (0.72 W cm − 2 ).…”

Section: Chalcogenide-based Nanomaterialsmentioning

confidence: 99%

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

et al. 2016

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With the development of nonlinear optics and new imaging methods, near-infrared (NIR) light can excite contrast agents to probe biological specimens both functionally and structurally with a deeper imaging depth and a higher spatial resolution than linear optical approaches. There is considerable and growing interest in how biological specimens respond to NIR light. Moreover, the visible absorption band of most functional nanomaterials becomes NIR-excitable through multiphoton processes, thus allowing multifunctional imaging and combined therapy with noble metal and magnetic nanoparticles both in vitro and in vivo. A groundbreaking example is the use of different laser techniques to excite single-type NIR-absorbing/emitting nanomaterials to produce multiphoton emission by femtosecond lasers using either a remote control system for photodynamic therapy or photo-induced chemical bond dissociation. These techniques provided superior anatomical resolution and detection sensitivity for in vivo tumor-targeted imaging than those offered by conventional methods. Here we summarize the most recent progress in the development of smart NIR-absorbing/emitting nanomaterials for in vivo bioapplications.

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“…• C within 400 s by irradiation with a 980 nm laser (0.72 W/cm 2 ), which probably efficiently induces cancer cells death [29].…”

Section: Resultsmentioning

confidence: 99%

A Novel Photothermal Nanocrystals of Cu7S4 Hollow Structure for Efficient Ablation of Cancer Cells

et al. 2014

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Cu2-xS nanocrystals (NCs), characterized by low cost, low toxicity, high stability and high photothermal conversion efficiency, provide promising platforms as photothermal agents. Herein, a novel twostep synthesis has been developed for Cu7S4 nanocrystals with hollow structure using the as-prepared copper nanoparticles as starting a solid precursor followed by hot-injection of sulfide source.The Cu7S4 NCs exhibit intense absorption band at Near-infrared (NIR) wavelengths due to localized surface plasmon resonance (LSPR) mode, which can effectively convert 980 nm-laser energy into heat.Moreover, the localized high temperature created by Cu7S4 NCs under NIR irradiation could result in efficient photothermal ablation (PTA) of cancer cells in vivo, demonstrating a novel and promising photothermal nanomaterials.

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Ultrathin PEGylated W₁₈O₄₉ Nanowires as a New 980 nm‐Laser‐Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo

Cited by 375 publications

References 45 publications

PEGylated WS₂ Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

PEGylated WS₂ Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

A Novel Photothermal Nanocrystals of Cu7S4 Hollow Structure for Efficient Ablation of Cancer Cells

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Ultrathin PEGylated W18O49 Nanowires as a New 980 nm‐Laser‐Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo

Cited by 375 publications

References 45 publications

PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

A Novel Photothermal Nanocrystals of Cu7S4 Hollow Structure for Efficient Ablation of Cancer Cells

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Product

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Ultrathin PEGylated W₁₈O₄₉ Nanowires as a New 980 nm‐Laser‐Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo

PEGylated WS₂ Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

PEGylated WS₂ Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy