Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Wu, Mengge; Yao, Kuanming; Huang, Ningge; Li, Hu; Zhou, Jingkun; Shi, Rui; Li, Jiyu; Huang, Xingcan; Li, Jian; Jia, Huiling; Gao, Zhan; Wong, Tsz Hung; Li, Dengfeng; Hou, Senlin; Liu, Yiming; Zhang, Shiming; Yu, Junsheng; Yu, Xinge

doi:10.1002/advs.202300504

Cited by 32 publications

(29 citation statements)

References 71 publications

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“…PEDOT:PSS were synthesized by mixing 10 mL of aqueous dispersion (Clevios PH1000) with 5 vol% ethylene glycols to improve film conductivity, 0.25 vol% 4-dodecylbenzenesulfonic acid (DBSA) to enhance film homogeneity, and 1 vol% crosslinker of (3-glycidyloxypropyl) trimethoxysilane, as our previous work reported. 24 Then stir the mixed solution for 2 days at room temperature. To make PEDOT:PSS stretchable, a soft polymer of poly(2-acrylamido-2methyl-1-propanesulfonic acid) (PAAMPSA, average M w of 2 000 000, 15 wt% in H 2 O, Sigma-Aldrich) was added into the prepared PEDOT:PSS solution with a ratio of 30 wt% and followed by stirring for 1 h.…”

Section: Discussionmentioning

confidence: 99%

Stretchable, skin‐conformable neuromorphic system for tactile sensory recognizing and encoding

Wu,

Zhuang,

Yao

et al. 2023

InfoMat

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Expanding wearable technologies to artificial tactile perception will be of significance for intelligent human–machine interface, as neuromorphic sensing devices are promising candidates due to their low energy consumption and highly effective operating properties. Skin‐compatible and conformable features are required for the purpose of realizing wearable artificial tactile perception. Here, we report an intrinsically stretchable, skin‐integrated neuromorphic system with triboelectric nanogenerators as tactile sensing and organic electrochemical transistors as information processing. The integrated system provides desired sensing, synaptic, and mechanical characteristics, such as sensitive response (~0.04 kPa−1) to low‐pressure, short‐ and long‐term synaptic plasticity, great switching endurance (>10 000 pulses), symmetric weight update, together with high stretchability of 100% strain. With neural encoding, demonstrations are capable of recognizing, extracting, and encoding features of tactile information. This work provides a feasible approach to wearable, skin‐conformable neuromorphic sensing system with great application prospects in intelligent robotics and replacement prosthetics.

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Section: Discussionmentioning

confidence: 99%

Stretchable, skin‐conformable neuromorphic system for tactile sensory recognizing and encoding

Wu,

Zhuang,

Yao

et al. 2023

InfoMat

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“…[103,104] Figure 3A-III illustrates an example of a soft, bioresorbable OECT interface for the short-term monitoring of brain activity. [98] Here, the OECT array consists of a PEDOT:PSS organic semiconductor, an Au electrode, and poly(lactic-co-glycolic acid) (PLGA) substrate, which have all been proven to be biocompatible materials. [105][106][107] The 10 � 10 active PEDOT:PSS channels (rectangular area of 200 � 20 μm 2 , 200 nm thick) distributed over an area of 0.64 cm 2 provide high transconductance up .…”

Section: Electrochemical Semiconductor-based Neural Interfacesmentioning

confidence: 99%

“…Inset shows a unit recording cell with a multiplexer transistor and a conductively coupled amplifier transistor (channel length of 16 μm, width of 80 μm, thickness of 60 nm). Panels reproduced with permission from (A-I), [96] American Chemical Society; (A-II), [97] AAAS; (A-III), [98] Wiley; (B-I), [72] Springer Nature Ltd; (B-II), [99] AAAS; (B-III), [100] American Physiological Society; (C-I), [51] Springer Nature Ltd; (C-II), [101] PNAS. to 8.67 mS.…”

Section: Electrochemical Semiconductor-based Neural Interfacesmentioning

confidence: 99%

“…Recent efforts have also focused on developing a biodegradable neural interface that completely disappears in the body through a bioresorption process after completing its functions [103,104] . Figure 3A‐III illustrates an example of a soft, bioresorbable OECT interface for the short‐term monitoring of brain activity [98] . Here, the OECT array consists of a PEDOT:PSS organic semiconductor, an Au electrode, and poly(lactic‐co‐glycolic acid) (PLGA) substrate, which have all been proven to be biocompatible materials [105–107] .…”

Section: Active Semiconductor‐enabled Neural Recordingsmentioning

confidence: 99%

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Flexible, ultrathin bioelectronic materials and devices for chronically stable neural interfaces

Zhou,

Wu,

Sun

et al. 2023

Brain-X

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Advanced technologies that can establish intimate, long‐lived functional interfaces with neural systems have attracted increasing interest due to their wide‐ranging applications in neuroscience, bioelectronic medicine, and the associated treatment of neurodegenerative diseases. A critical challenge of significance remains in the development of electronic platforms that offer conformal contact with soft brain tissue for the sensing or stimulation of brain activities and chronically stable operation in vivo, at scales that range from cellular‐level resolution to macroscopic areas. This review summarizes recent advances in this field, with an emphasis on the use of demonstrated concepts, constituent materials, engineered designs, and system integration to address the current challenges. The article begins with an overview of recent bioelectronic platforms with unique form factors, ranging from filamentary probes to conformal sheets and three‐dimensional frameworks for alleviating the mechanical mismatch between interface materials and neural tissues. Next, active interfaces which utilize inorganic/organic semiconductor‐enabled devices are reviewed, highlighting various working principles of recording mechanisms including capacitively and conductively coupled sensing enabled by high transistor matrices at high spatiotemporal resolution. The subsequent section presents approaches to biological integration which use active materials for multiplexed addressing, local amplification and multimodal operation with high‐channel‐count and large‐scale electronic systems in a safe fashion that provides multi‐decade stable performance in both animal models and human subjects. The advances summarized in this review will guide the future direction of this technology and provide a basis for next‐generation chronic neural interfaces with long‐lived high‐performance operation.

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“…Tissue-integrated devices are an important class of biomedical instruments that aid in optimizing performance of the human body. [1][2][3][4][5][6][7][8] These devices include wearable and implantable biochemical and biophysical sensors, [9][10][11][12][13][14][15][16] drug delivery platforms, [17][18][19] and organ function optimizing devices, such as pacemakers [20,21] and implantable cardiac defibrillators. [22][23][24] DOI: 10.1002/adma.202303197 Tissue-integrated sensors enable close monitoring of various metabolic, electrolytic, proteomic, electrical, kinematic, thermal, and vascular dynamics parameters which provide unprecedented insights into the biological processes occurring within the body.…”

Section: Introductionmentioning

confidence: 99%

Biofluid‐Activated Biofuel Cells, Batteries, and Supercapacitors: A Comprehensive Review

Garland,

Kaveti,

Bandodkar

2023

Advanced Materials

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Recent developments in wearable and implanted devices have resulted in numerous, unprecedented capabilities that generate increasingly detailed information about a user's health or provide targeted therapy. However, options for powering such systems remain limited to conventional batteries which are large and have toxic components and as such are not suitable for close integration with the human body. This review provides an in‐depth overview of biofluid‐activated electrochemical energy devices, an emerging class of energy sources judiciously designed for biomedical applications. These unconventional energy devices are composed of biocompatible materials that harness the inherent chemistries of various biofluids to produce useable electrical energy. This article covers examples of such biofluid‐activated energy devices in the form of biofuel cells, batteries, and supercapacitors. Advances in materials, design engineering, and biotechnology that form the basis for high performance, biofluid‐activated energy devices are discussed. Innovations in hybrid manufacturing and heterogeneous integration of device components to maximize power output are also included. Finally, key challenges and future scope of this nascent field are provided.This article is protected by copyright. All rights reserved

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Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Cited by 32 publications

References 71 publications

Stretchable, skin‐conformable neuromorphic system for tactile sensory recognizing and encoding

Stretchable, skin‐conformable neuromorphic system for tactile sensory recognizing and encoding

Flexible, ultrathin bioelectronic materials and devices for chronically stable neural interfaces

Biofluid‐Activated Biofuel Cells, Batteries, and Supercapacitors: A Comprehensive Review

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