Ultraviolet A1-induced downregulation of human <i>β</i>
-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma

Kreuter, Alexander; Hyun, Julia; Skrygan, Marina; Sommer, Anna; Bastian, Andreas; Altmeyer, Peter; Gambichler, Thilo

doi:10.1111/j.1365-2133.2006.07391.x

Cited by 65 publications

(53 citation statements)

References 21 publications

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“…Interleukin-6 was demonstrated to increase the production of collagen and aminoglycans in the fibroblast culture and some authors disclosed increased levels of IL-6 in patients with LS as well as in those with systemic sclerosis and a correlation between the level of this cytokine and clinical improvement of skin lesions, which indicates a crucial role of IL-6 in the metabolism of connective tissue [32][33][34]. Ihn et al detected increased IL-6 in serum of 23/48 patients with LS [35].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of serum concentrations of the selected cytokines in patients with localized scleroderma

Budzyńska-Włodarczyk

Michalska-Jakubus²,

Kowal³

et al. 2016

pdia

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A b s t r a c t Introduction: Localized scleroderma is an autoimmune disease primarily affecting the skin. The cause of disease remains unexplained although environmental factors are implicated, which are likely to be responsible for activation of the endothelium and subsequent inflammation leading to excessive synthesis of collagen and extracellular matrix components. Aim: To determine concentrations of interleukin (IL)-27, transforming growth factor (TGF)-β1, TGF-β2, IL-6, and sIL-6R in patients with localized scleroderma compared to controls and to assess the relations between their levels and laboratory markers. Material and methods: The study encompassed 17 females with localized scleroderma (aged 25-67). The control group consisted of 30 age-matched healthy women. The blood was sampled from the basilic vein. Serum levels of cytokines were determined using ELISA. Results: The TGF-β2 levels were found to be significantly lower in patients with localized scleroderma compared to controls. Concentrations of TGF-β1 were decreased in scleroderma patients when compared to controls but without statistical significance. There were no significant differences in serum IL-6, sIL-6R and IL-27 levels between patients and the control group; however, we found a significant positive correlation between the level of sIL-6 and ESR among subjects with localized scleroderma. Conclusions: The findings of decreased serum levels of TGF-β1 and TGF-β2 in patients with localized scleroderma demonstrate a possible association of these cytokines with pathogenesis of the disease. The results suggest also that sIL-6R is likely to be involved in inflammation in patients with localized scleroderma.

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Section: Discussionmentioning

confidence: 99%

“…Interestingly, with the improvement of skin lesions following radiation with a UVA1, the IL-6 level in the affected skin and its serum concentration substantially decreased [32].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum concentrations of the selected cytokines in patients with localized scleroderma

Budzyńska-Włodarczyk

Michalska-Jakubus²,

Kowal³

et al. 2016

pdia

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“…A good placebo-controlled study still needs to be conducted for localized scleroderma and phototherapy. Kreuter et al [8,9] showed that UVA-1 was associated with significant downregulation of interleukin-6 and interleukin-8 and decreased the inhibitory SMAD7 gene expression.…”

Section: Outcome Measures and Treatmentmentioning

confidence: 98%

Scleroderma Mimics

Nashel

Steen

2011

Curr Rheumatol Rep

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Scleroderma is a rare systemic autoimmune disease with multiple organ manifestations, including skin fibrosis. The groups of disorders classified as scleroderma mimics share the common thread of skin thickening but are otherwise quite incongruous in terms of underlying disease process and other organ involvement. This article reviews the clinical presentation, etiology, and treatment options available for scleroderma mimics, including morphea, scleredema, diabetic cheiroarthropathy, scleromyxedema, nephrogenic systemic fibrosis, and eosinophilic fasciitis. Through greater understanding of these diseases and the associated extradermal implications, we hope to facilitate recognition of scleroderma and its mimics.

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“…UV light was chosen as the preferred damaging agent because of its well known ability to provoke DNA breakdown, particularly in SLE patients. The wavelength used in this study (UV-C, 250 nm), is far from the UV-A emission (340 -400 nm) recently used to perform phototherapy in patients with localized scleroderma, with good results [31].…”

Section: Enzyme Activity Assaymentioning

confidence: 99%

Poly(ADP-ribose) polymerase activity in systemic lupus erythematosus and systemic sclerosis

et al. 2009

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Ultraviolet A1-induced downregulation of human β -defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma

Abstract: hBDs and IL-6 and IL-8, cytokines with pivotal importance in sclerotic skin diseases, are downregulated by UVA1 in the lesional skin of patients with LS. Their pathogenetic relevance with respect to clinical improvement needs further investigation.

Cited by 65 publications

References 21 publications

Evaluation of serum concentrations of the selected cytokines in patients with localized scleroderma

Evaluation of serum concentrations of the selected cytokines in patients with localized scleroderma

Scleroderma Mimics

Poly(ADP-ribose) polymerase activity in systemic lupus erythematosus and systemic sclerosis

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