Ultraviolet B irradiation increases the expression of trichohyalin‐like 1 protein in human skin xenotransplants

Makino, Teruhiko; Mizawa, Megumi; Yoshihisa, Yoko; Shimizu, Tadamichi

doi:10.1111/ced.13904

Cited by 11 publications

(13 citation statements)

References 11 publications

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“…These differences may explain why only one EDC gene, TCHHL1 (trichohyalin-like 1), is convergently inactivated in cetaceans and hippos (Figure 5). TCHHL1 is predominantly expressed in the stratum basale and its specific function in keratinocyte differentiation remains unclear [87,88]. Among suprabasal keratins, only KRT2 and KRT77 are independently inactivated in hippos (Figure 5), and the overall degree of suprabasal keratin inactivation in hippos is less than in obligately-aquatic manatees, which are more similar to cetaceans [16].…”

Section: Comparison Of Inactivated Skin Genes and Epidermal Phenotype...mentioning

confidence: 99%

Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos

et al. 2021

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Section: Comparison Of Inactivated Skin Genes and Epidermal Phenotype...mentioning

confidence: 99%

Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos

et al. 2021

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“…The UVB light source was a fluorescent lamp (GL40SE; Sankyo Denki Co, Kanagawa, Japan), that emitted 0.1 mW/cm 2 of UV light between 280 and 315 nm (peak: 306 nm) at a distance of 40 cm, as measured using a UV radiometer (EKO Instruments Co., Tokyo, Japan). Two months after transplantation, the grafted skin was exposed to 500 mJ/cm 2 of UVB, which is the minimal dose necessary to induce pyrimidine dimers, sun‐burn cells, and apoptotic keratinocytes in human skin xenotransplants 11–13 . Skin tissues were excised 2 days after UVB irradiation and analysed by immunohistochemistry.…”

Section: Experimental Designmentioning

confidence: 99%

Ultraviolet B irradiation increases the expression of cornulin and retepin in human skin xenotransplants

Makino,

Mizawa,

Takemoto

et al. 2024

Experimental Dermatology

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Cornulin (CRNN) and repetin (RPTN) belong to the fused‐type S100 protein family. Although these proteins have been reported to be expressed in the granular layer of the epidermis and have been suggested to be associated with barrier formation in the epidermis, their exact function remains unclear. This study examined the effects of ultraviolet B (UVB) irradiation on CRNN and RPTN expression in human skin xenotransplantation. The CRNN expression increased in the granular layer of UVB‐irradiated skin 2 days after UVB irradiation compared to that in sham‐irradiated skin. Interestingly, CRNN signals were observed not only in the cytoplasm, but also in the peripheral regions of granular keratinocytes. In contrast, RPTN was rarely expressed in sham‐irradiated skin; however, RPTN signals were markedly increased in the granular layer of the UVB‐irradiated skin. In addition, activation of ERK1/2 and STAT3 was observed in UVB‐irradiated skin. Accordingly, the present study demonstrated that CRNN and RPTN are novel proteins whose expression can be increased by UVB irradiation. The activation of ERK1/2 and STAT3 may be associated with the regeneration of a UVB‐damaged epidermis, and CRNN and RPTN may be induced to repair any dysfunction in the epidermal barrier during this regeneration process.

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“…The production of TCHHL1 molecules in healthy and diseased skin cells was studied using a monoclonal antibody raised against the C-terminus of the TCHHL1 molecule. [ 4 ] The focus of this research was to see how ultraviolet B (UVB) irradiation affected TCHHL1 expression levels of skin xenotransplants. TCHHL1 expression levels increased by two days following UVB irradiation in UVB-exposed skins.…”

Section: Related Workmentioning

confidence: 99%

Clinical Treatment Study of Secondary Multiple Squamous Cell Carcinoma with Psoriasis Vulgaris

Han

Feng

2022

Journal of Oncology

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Dermatologic diseases are the fourth most frequent nonfatal common illness, yet they have a psychological, economical, and professional burden that is comparable to or larger than other chronic conditions. From a survey in China of 6 provinces, the overall prevalence of psoriasis with squamous cell carcinoma was 0.47%. According to the current investigation, the outburst of skin disease was not associated with gender, but mainly with the climate of the environment; that is, dry cold weather will more likely to induce psoriasis. Approximately 3% of people around the world have psoriasis, which is near the most common autoimmune skin disease in adults. By simple estimation, there are at least two hundred million psoriasis patients in the world. Therefore, it is not just a simple health problem in a country or a region but a serious global challenge. Of note, about half of the adult patients had been reported to be sick in their childhood and they mostly fell ill around 10 years old. Actinic keratosis is perhaps the most common, followed by squamous cell carcinoma and, to a lesser extent, acne vulgaris, psoriasis, and hidradenitis suppurativa, as well as dermatitis herpetiformis. 5-Fluorouracil (5-FU) 0.5 percent is used topically to treat actinic keratosis and squamous cell carcinoma with good outcomes, while it might cause significant toxicity in certain patients. Dapsone, a Valosin-containing protein, is a medication that is often used to treat inflammatory skin disorders like psoriatic arthritis, but it can occasionally cause hemolytic anemia. Furthermore, biologic medications for the treatment of moderate-to-severe psoriasis and multiple squamous cell carcinoma have proven to be successful and safe; nevertheless, a small percentage of patients do not react to biologic treatment in the long term or do not respond at all. Based on the data from the China Food and Drug Administration, the majority of chemical drugs are utilized as the topical formulations, while Chinese medicines are mainly delivered by an oral route, suggesting that the market for topical preparations of Chinese medicine to treat skin diseases like psoriasis is worth exploration. This large interindividual diversity in response could be caused by changes in genes that encode proteins implicated in the disease’s pathologic environment or the medication’s mechanism of action. Pharmacogenetics is the study of the association between genetic differences and medication response, which is valuable for identifying nonresponsive patients and those who are more likely to suffer toxicity as a result of treatment. This study highlights the pharmacogenetic recommendations for dermatology therapies that have the strongest evidence at this time, highlighting those that have been incorporated in clinical practice guides. Pharmacogenetic clinical guidelines for multiple squamous cell carcinoma and psoriasis vulgaris were found in this investigation. Here, for multiple squamous cell carcinoma trichohyalin-like 1 (TCHHL1), 5-fluorouracil (5-FU) 0.5% is recommended. Along with that dapsone, Valosin-containing protein can be recommended for treating the psoriasis vulgaris. We made some clinical trials over the two diseases, and from the result obtained, we hypothesize that the suggested drug may be a novel therapeutic target in treating the multiple squamous cell carcinoma with psoriasis vulgaris.

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Ultraviolet B irradiation increases the expression of trichohyalin‐like 1 protein in human skin xenotransplants

Cited by 11 publications

References 11 publications

Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos

Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos

Ultraviolet B irradiation increases the expression of cornulin and retepin in human skin xenotransplants

Clinical Treatment Study of Secondary Multiple Squamous Cell Carcinoma with Psoriasis Vulgaris

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