1978
DOI: 10.1016/0022-2836(78)90104-3
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Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast

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1978
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Cited by 92 publications
(75 citation statements)
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“…Evolutionarily Conserved Rev1 CTD-Rev7 Interaction-The similar genetic phenotypes caused by deficiencies of REV1, REV3, and REV7 in yeast and mammalian cells have long implicated a functional connection of Rev1 with Rev3 and Rev7 in the Pol complex (5,30,37,38), and their physical interaction has been biochemically observed in yeast and vertebrate species (12, 13, 16, 39 -41). Despite the biochemical verification of an evolutionarily conserved interaction between Rev1 and Rev7, there has been speculation about the structural conservation of such an interaction because Rev1 and Rev7 both show a large degree of sequence variation in yeast and vertebrates, raising the question of whether vertebrate and yeast Rev1 and Rev7 proteins use different molecular surfaces to interact with each other.…”
Section: Discussionmentioning
confidence: 99%
“…Evolutionarily Conserved Rev1 CTD-Rev7 Interaction-The similar genetic phenotypes caused by deficiencies of REV1, REV3, and REV7 in yeast and mammalian cells have long implicated a functional connection of Rev1 with Rev3 and Rev7 in the Pol complex (5,30,37,38), and their physical interaction has been biochemically observed in yeast and vertebrate species (12, 13, 16, 39 -41). Despite the biochemical verification of an evolutionarily conserved interaction between Rev1 and Rev7, there has been speculation about the structural conservation of such an interaction because Rev1 and Rev7 both show a large degree of sequence variation in yeast and vertebrates, raising the question of whether vertebrate and yeast Rev1 and Rev7 proteins use different molecular surfaces to interact with each other.…”
Section: Discussionmentioning
confidence: 99%
“…Ultraviolet (UV)-induced mutagenesis is substantially reduced in rev mutant strains, and such strains are also mildly hypersensitive to the lethal e¡ect of the radiation, indicating that the normal functions of the REV genes contribute a small component to the ability of yeast cells to tolerate DNA damage. UV-induced reversion frequencies of a set of 13 de¢ned test alleles in REV + and null rev mutant strains indicates that more than 95% of the base pair substitution mutations induced by this mutagen depend on REV1 and REV3 functions (Lawrence & Christensen 1978, while a smaller set of data suggests that the phenotype of REV7 is like that of REV3 (Lawrence et al 1985a,c). Similar experiments with a set of eight frameshift test alleles indicate that more than 90% of this type of mutation depend on REV3 activity, and the same is true of REV1 for frameshift induction at some genetic sites, although at most the dependence is much less or non-existent (Lawrence & Christensen 1978Lawrence et al 1984).…”
Section: Mutagenesis In Yeastmentioning
confidence: 99%
“…UV-induced reversion frequencies of a set of 13 de¢ned test alleles in REV + and null rev mutant strains indicates that more than 95% of the base pair substitution mutations induced by this mutagen depend on REV1 and REV3 functions (Lawrence & Christensen 1978, while a smaller set of data suggests that the phenotype of REV7 is like that of REV3 (Lawrence et al 1985a,c). Similar experiments with a set of eight frameshift test alleles indicate that more than 90% of this type of mutation depend on REV3 activity, and the same is true of REV1 for frameshift induction at some genetic sites, although at most the dependence is much less or non-existent (Lawrence & Christensen 1978Lawrence et al 1984). Mutagenesis induced by a variety of other mutagens also depends on REV gene products (McKee & Lawrence 1979;Lawrence et al 1985c), suggesting that Pol z is responsible for replication past a broad range of DNA lesions.…”
Section: Mutagenesis In Yeastmentioning
confidence: 99%
“…Curiously, however, the loss of Rad5 function adversely affects UV-induced reversion of ochre alleles (Lemontt 1971;Lawrence and Christensen 1978;Johnson et al 1992). For example, UV-induced reversion of arg4-17 to Arg1 is reduced $10-fold in the rad5D strain ( Johnson et al 1992).…”
mentioning
confidence: 99%