Ultraviolet-induced surface grafting of octafluoropentyl methacrylate on polyether ether ketone for inducing antibiofilm properties

Abstract

Since octafluoropentyl methacrylate is an antifouling polymer, surface modification of polyether ether ketone with octafluoropentyl methacrylate is a practical approach to obtaining anti-biofilm biocompatible devices. In the current study, the surface treatment of polyether ether ketone by the use of ultraviolet irradiation, so as to graft (octafluoropentyl methacrylate) polymer chains, was initially implemented and then investigated. The Fourier-transform infrared and nuclear magnetic resonance spectra corroborated the appearance of new signals associated with the fluoroacrylate group. Thermogravimetric curves indicated enhanced asymmetry in the polymer structure due to the introduction of the said new groups. Measuring the peak area in differential scanning calorimetry experiments also showed additional bond formation. Static water contact angle measurements indicated a change in wettability to the more hydrophobic surface. The polyether ether ketone-octafluoropentyl methacrylate surface greatly reduced the protein adsorption. This efficient method can modulate and tune the surface properties of polyether ether ketone according to specific applications.

Improvement in the Microbial Resistance of Resin-Based Dental Sealant by Sulfobetaine Methacrylate Incorporation

“…The marked reduction in BSA adsorption and the adsorption of proteins from the BHI medium with the increasing SB content observed in this study suggests SB-incorporated resin-based sealants can prevent the formation of such proteinaceous pellicles. Similar findings were reported in earlier studies that described the incorporation of other QAS such as dimethylaminohexadecyl methacrylate [15,23], methacryloyloxyethyl phosphorylcholine [10], and octafluoropentyl methacrylate [27]. The influence of sulfobetaine in particular has also been substantiated in earlier studies analyzing surface coatings [14,28,29], including dental varnish [10].…”

Bond strength of an orthodontic adhesive containing an antibiofilm agent (octafluoropentyl methacrylate)

“…An antifouling feature of the OFPA was investigated in a previous study by authors,[ 12 ] but literature lacks information regarding mechanical properties of an orthodontic adhesive containing OFPA. The novelty of the current study is that according to the literature, this is the first time that OFPA is included in dentistry materials, especially orthodontic adhesives.…”

“…The authors have proposed that OFPA-coated materials express a protein repellent, the antifouling feature which could be effectively applied in materials which have direct contact with salivary glycoproteins such as orthodontic materials. [ 12 ] No previous study has investigated this material in the field of dentistry and orthodontics. Therefore, this study aimed to fill the gap by incorporating OFPA monomer into orthodontic adhesives and assessing its effect on the bracket bond strength.…”

Biomaterial approaches for the treatment and prevention of orthopaedic infections

“…Osteocytes could potentially represent a very specific target for bone tissue. Some osteocyte markers like dentin matrix protein 1 (DMP1), sclerostin and matrix extracellular phosphoglycoprotein (MEPE) are reported in literature and could be used in targeting these cells [14]. Nevertheless, bone cells do not represent attractive targets for DDS as they are embedded in dense inorganic matrix, making them poorly accessible for DDS constructs.…”

“…Orthopaedic implants are commonly used to fill bone defects, act as fracture support structures or restore function to load bearing joints and are susceptible to bacterial colonization. This is because the patient's immune response [14] and effects of systemic drugs are severely diminished at the surface of the implant [5].…”