Ultraviolet irradiation modulates ABO blood group antigens in human skin in vivo: Possible implication in skin aging

Lee, Dong Hun; Jung, Ji Yong; Oh, Joo Youn; Lee, Serah; Kim, Yeon Kyung; Chung, Jin Ho

doi:10.1016/j.jdermsci.2012.01.006

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…As well as RBCs, many other tissues also express ABH antigens, including the epithelium of skin, salivary glands, respiratory mucosa, and gastrointestinal and urogenital tracts (Storry and Olsson, ). In epidermis, A and B antigens are expressed on the cornified and granular layers, whereas H antigen is found on the upper portion of the spinous layer, and decreased A and B antigen expression in sun‐exposed skin may suggest their possible role in photoaging (Dabelsteen et al, ; Lee et al, ).…”

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confidence: 99%

Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells

Jung

Lee

et al. 2013

Journal Cellular Physiology

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ABO blood group is determined by carbohydrate antigens, called ABH antigens. It has been known that the change of carbohydrate antigen expression, including ABH antigens, has correlation with the tumor metastasis and survival; however, the exact mechanism remains to be elucidated. ABH antigens are expressed not only in blood cells but also in several tissues. In epidermis, ABH antigen is expressed in the uppermost spinous and granular layer. We investigated the role of ABH antigens on the cell migration of HaCaT keratinocytes, which express B antigen. Knock-down of B antigen expression by small interference RNA of FUT1 inhibited HaCaT cell migration. At that time, we found that lamellipodia and actin fiber were also reduced by knock-down of B antigen expression. The transcription of cdc42, a kind of Rho GTPase which plays a key role in actin polymerization, was reduced by down-regulated B antigen expression. Furthermore, the reduced B antigen expression also inhibited the interaction of cdc42 and N-WASP. Collectively, our data provide a clue how ABH antigens regulate the cell migration mechanism.

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confidence: 99%

Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells

Jung

Lee

et al. 2013

Journal Cellular Physiology

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“…In our speculation, because ABO blood type antigen expression is observed only in keratinocytes at the granular layer and upper spinous layers, but not in while fibroblasts or melanocytes 4 , the blood type-specific regulation of wrinkle formation and melanin production may be mediated via some indirect regulations finally targeting for the ABO antigen-absent cells. Or, it is possibly because of the association of ABO blood type and personality trait-related genes, i.e., catecholamine activity-related enzymes, including dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA) 8 .…”

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confidence: 69%

“…In addition to the RBCs, the blood group antigen expression was also found on many other tissues or secretions, including the granular layer of the epidermis 2 4 . However, still little evidence for their physiological roles has not been accumulated yet.…”

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confidence: 99%

Deeper Wrinkle Formation and Less Melanin Production in Aged Korean Women with B Blood Type

Park

et al. 2018

Ann Dermatol

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“…While it is established that ABH antigens determine individual blood types through their expression on the erythrocyte membrane ( 32 ), our prior research, along with other studies, have reported that these antigens are predominantly distributed in various tissues. Notably, they are concentrated in regions in direct contact with the external environment, such as the skin, intestines, oral cavity, and liver ( 33 – 36 ). Additional studies have revealed that the expression of FUT1 is restricted to a limited extent within epithelial cells ( 37 – 39 ).…”

Section: Introductionmentioning

confidence: 99%

“…Additional studies have revealed that the expression of FUT1 is restricted to a limited extent within epithelial cells ( 37 – 39 ). The association between the expression of ABH antigens and inflammatory responses, including those induced by UV irradiation, breast and ovarian cancer, respiratory diseases, and pathogen infections, has been explored ( 33 , 39 – 43 ). Despite this, the specific involvement of ABH antigens in skin diseases has remained largely elusive.…”

Section: Introductionmentioning

confidence: 99%

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

Li,

Oh,

Suh

et al. 2024

Front. Immunol.

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The presence of the blood group H2 antigen on the membrane of red blood cells determines blood type O in individuals and this H2 antigen serves as a precursor to the A and B antigens expressed in blood types A and B, respectively. However, the specific involvement of ABH antigens in skin diseases is unknown. Therefore, we aim to investigate the expression of ABH antigens in skin tissue of patients with atopic dermatitis (AD) and MC903-induced AD-like mice. We demonstrated that the expression of ABH antigen is primarily located in the granular and horny layers of the skin in healthy control individuals. However, in patients with AD, the expression of the ABH antigen was absent or diminished in these layers, while the H2 antigen expression increased in the spinous layers of the affected skin lesions. Then, we investigated the biological function of blood group H antigen mediated by fucosyltransferase 1 (Fut1) in the skin, utilizing an AD mouse model induced by MC903 in wild-type (WT) and Fut1-knockout mice. After the application of MC903, Fut1-deficient mice, with no H2 antigen expression on their skin, exhibited more severe clinical signs, increased ear swelling, and elevated serum IgE levels compared with those of WT mice. Additionally, the MC903-induced thickening of both the epidermis and dermis was more pronounced in Fut1-deficient mice than that in WT mice. Furthermore, Fut1-deficient mice showed a significantly higher production of interleukin-4 (IL-4) and IL-6 in skin lesions compared with that of their WT counterparts. The expression of chemokines, particularly Ccl2 and Ccl8, was notably higher in Fut1-deficient mice compared with those of WT mice. The infiltration of CD4+ T cells, eosinophils, and mast cells into the lesional skin was significantly elevated in Fut1-deficient mice compared with that in WT mice. These findings demonstrate the protective role of H2 antigen expression against AD-like inflammation and highlight its potential therapeutic impact on AD through the regulation of blood group antigens.

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Ultraviolet irradiation modulates ABO blood group antigens in human skin in vivo: Possible implication in skin aging

Cited by 8 publications

References 10 publications

Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells

Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells

Deeper Wrinkle Formation and Less Melanin Production in Aged Korean Women with B Blood Type

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

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