2014
DOI: 10.1177/0961203314530488
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Ultraviolet radiation and systemic lupus erythematosus

Abstract: Exposure to ultraviolet (UV) radiation is among the environmental factors that have been proposed and studied in association with systemic lupus erythematosus (SLE). While it is known that UV radiation exposure may exacerbate pre-existing lupus, it remains unclear whether UV exposure is a risk factor for the development of SLE. Experimental studies show a significant immunomodulatory role for UV radiation, but strong epidemiologic data regarding its role in triggering SLE onset are lacking. Further studies are… Show more

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Cited by 93 publications
(63 citation statements)
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“…Our studies, as well as those of others, have demonstrated that Th17 cells play a key role in the pathogenesis of SLE [17, 18, 54]. Environmental factors, including exposure to UV radiation, infection, environmental pollution, and emotional changes, are believed to contribute to the increased prevalence of SLE and to aggravate lupus activity [55]. UV radiation exposure is among the environmental factors that have been studied the most with respect to association with SLE [55, 56].…”
Section: Oxidative Stress and Th17 Abnormalitysupporting
confidence: 58%
“…Our studies, as well as those of others, have demonstrated that Th17 cells play a key role in the pathogenesis of SLE [17, 18, 54]. Environmental factors, including exposure to UV radiation, infection, environmental pollution, and emotional changes, are believed to contribute to the increased prevalence of SLE and to aggravate lupus activity [55]. UV radiation exposure is among the environmental factors that have been studied the most with respect to association with SLE [55, 56].…”
Section: Oxidative Stress and Th17 Abnormalitysupporting
confidence: 58%
“…Only a few case-control studies have been able to examine UV radiation exposure and risk of SLE(68–70), and these have been limited by potential inaccuracy of exposure assessment, and influenced by recall and reverse causation bias, given that photosensitivity due to SLE can be present well before diagnosis. We have recently reviewed this topic in detail elsewhere(71). Large, well-controlled studies are still needed to prospectively assess the relationship of UV-B radiation with incident SLE.…”
Section: Radiation and Nutritional Factorsmentioning
confidence: 99%
“…9093 Ultraviolet-B light is well known to cause SLE exacerbations and its potential pathogenic mechanism in aberrant apoptosis and the removal of cellular debris make this a key candidate in the etiological role for SLE, particularly for cutaneous manifestations. 94 Epstein-Barr (EBV) virus has been suggested to be involved in the pathogenesis of SLE based on high EBV viral loads in pediatric SLE patients compared to controls, with posited molecular mimicry of EBV antigens and autoantigens targeted by lupus autoantibodies. 95, 96 However, the association of EBV and risk of SLE remains controversial.…”
Section: Introductionmentioning
confidence: 99%