Ultraviolet–visible study on acid–base equilibria of 2-substituted-4(3H)-quinazolinones

Sim, Yoke‐Leng; Omer, Noridayu; Khan, M. Niyaz; Pratt, Lawrence M.

doi:10.1016/j.tet.2013.01.067

Cited by 12 publications

(6 citation statements)

References 58 publications

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“…They concluded that the curves of 4(3H)-quinazolinones could be accounted for a mixture of tautomers due to the mobil hydrogen atom on N-3. The results showed a good correlation between experimentally determined pK a values and theoretically calculated energies [38].…”

Section: Uv Spectrasupporting

confidence: 60%

4(3H)-Quinazolinone Derivatives: Syntheses, Physical Properties, Chemical Reaction, and Biological Properties

Abbas¹

2020

Quinazolinone and Quinazoline Derivatives

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4(3H)-Quinazolinone derivatives have considerable great interesting due to the diverse range of their biological properties. This review summarized the methods of preparation of 2-substituted-4(3H)-quinazolinone, 3-substituted-4(3H)-quinazolinone and 2,3-disubstituted-4(3H)-quinazolinone derivatives. Chemical reaction of 4(3H)-quinazolinone derivatives and the reactivity of the 2-methyl group, reactivity of the 3-amino group, electrophilic substitution, oxidation, reduction, reaction of 4(3H)-quinazolinones with metal ions, Mannich reaction, cycloaddition reaction as well as other reagents were discussed. Also, biological properties of 4(3H)quinazolinone derivatives were given herein.

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Section: Uv Spectrasupporting

confidence: 60%

4(3H)-Quinazolinone Derivatives: Syntheses, Physical Properties, Chemical Reaction, and Biological Properties

Abbas¹

2020

Quinazolinone and Quinazoline Derivatives

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“…Buffer solutions of glycine, formate, acetate, MES, MOPS, HEPES and TRIS were used to guard the pH ranges from 3.0 to 11.0. The preparation of these buffers followed the standard method published by Perrin and Dempsey 40 41 .…”

Section: Antioxidant Assaymentioning

confidence: 99%

Ultraviolet-visible study on acid-base equilibria of aporphine alkaloids with antiplasmodial and antioxidant activities from Alseodaphne corneri and Dehaasia longipedicellata

Zahari

Ablat

Omer

et al. 2016

Sci Rep

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The UV-vis spectra of isocorydine 1, norisocorydine 2 and boldine 3 were studied in 2% v/v acetonitrile, at constant ionic strength (0.1 M NaCl, 35 degree Celsius). The pKa values of isocorydine 1 and norisocorydine 2 were 11.75 and 12.07, respectively. Boldine 3 gave a pKa value of 9.16 and 10.44. All of the alkaloids 1–3 were stable at physiological pH; thereby all of them will not ionize, thus permitting the basic nitrogen to be protonated and accumulated within the acidic food vacuole of Plasmodium via pH trapping. Subsequently, acidic food vacuoles that have been neutralized by alkaloids would result in enhancement of the antiplasmodial activity. The alkaloids showed antiplasmodial activity against Plasmodium falciparum and antioxidant activities; DPPH radical scavenging, metal chelating and ferric reducing power. The antioxidant properties of the alkaloids under investigation revealed that in addition to the antiplasmodial activity, the alkaloids can also prevent oxidative damage. It can be prevented by binding free heme and neutralizing the electrons produced during the Plasmodium falciparum mediated haemoglobin destruction in the host. Slightly basic properties of the aforementioned alkaloids, along with their antioxidant activities, are advantageous in improving the suppression of malaria infection that cause less damage to the host.

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“…It is known that 2‐aryl(hetaryl)‐ and 2‐styrylquinazolinones show distinctive fluorescence properties and therefore have potential for the creation of non‐linear optical generators . Variation of the structures, namely, the substituents in the heterocyclic and aryl fragments, allows one to obtain optical systems with various spectral parameters . Until now, the modification of benzazines with organometallic compounds has been limited to several examples with ferrocenyl and cymantrenyl derivatives …”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Studies of Photochemical Transformations of Cymantrenylquinazolinone Derivatives

et al. 2018

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For the first time, the photochemical properties of compounds 1-4 containing a cymantrene fragment at the 2-or 3-position of the quinazolinone have been studied. It was found that the -NC=O group in compounds 1 and 2 is capable of coordinating to the Mn atom with the formation of intramolecular chelates. The influence of the nature of the solvent and substituent in the side-chain of cymantrene on the thermo-[a] A. N. Nesmeyanov Institute of Organoelement Compounds,

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Ultraviolet–visible study on acid–base equilibria of 2-substituted-4(3H)-quinazolinones

Cited by 12 publications

References 58 publications

4(3H)-Quinazolinone Derivatives: Syntheses, Physical Properties, Chemical Reaction, and Biological Properties

4(3H)-Quinazolinone Derivatives: Syntheses, Physical Properties, Chemical Reaction, and Biological Properties

Ultraviolet-visible study on acid-base equilibria of aporphine alkaloids with antiplasmodial and antioxidant activities from Alseodaphne corneri and Dehaasia longipedicellata

Spectroscopic Studies of Photochemical Transformations of Cymantrenylquinazolinone Derivatives

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