Ultraviolet Wavelength Factors in Solar Radiation and Skin Cancer

Freeman, Robert G.; Hudson, Hugh T.; Carnes, Robin

doi:10.1111/j.1365-4362.1970.tb05122.x

Cited by 31 publications

(8 citation statements)

References 6 publications

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“…(for a review, see Coohill and Jacobson, 1981) point to the pyrimidine dimer as the most important photoproduct caused by UV irradiation, and therefore UVA is much less mutagenic compared with far UV radiation (Hsie et al, 1977;Jacobson et al, 1981). This is compatible with the observations from animal experiments, which show that UVB radiation is more efficient in skin cancer induction (Freeman et al ,1970).…”

Section: Introductionmentioning

confidence: 70%

Prior Exposure of Human Cells to Near Uv‐radiation Gives a Decrease in the Amount of the Unscheduled Dna‐synthesis Induced by Far Uv‐radiation

Holmberg¹

1983

Photochem & Photobiology

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Pretreatment of human cells with near UV radiation (UVA) in fluences exceeding 5 × 104 Jm−2 caused a decrease in the amount of the unscheduled DNA synthesis induced by far UV radiation (UVC). The DNA repair synthesis, as measured by the incorporation of [3H] ‐thymidine, is reduced by nearly a factor of 2 for a UVA radiation exposure of 1.5 × 105 Jm−2. Since solar UVA fluence rate is rather independent of latitude, this figure corresponds to a UVA exposure time of 50‐60 min from noon sunlight in the summer time.

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Section: Introductionmentioning

confidence: 70%

Prior Exposure of Human Cells to Near Uv‐radiation Gives a Decrease in the Amount of the Unscheduled Dna‐synthesis Induced by Far Uv‐radiation

Holmberg¹

1983

Photochem & Photobiology

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“…These workers also found that animals exposed to UVL and white light simultaneously appeared to be somewhat protected against carcinogenesis and suggested a photo-reversal effect by white light. Generally, howevw, wavelengths between 280-320 nm have been most efficient in producing cancers in a variety of animals (Rusch et al, 1941 ;Blum and Lippincott, 1942;Winkelmann et al, 1963;Freeman et al, 1970).…”

Section: B Skin Opticsmentioning

confidence: 99%

Experimental Ultraviolet Light-Carcinogenesis

Black

Chan

1977

Photochem Photobiol

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“…Indeed, W light penetrates the skin and causes connective tissue damage leading to wrinkling and early aging of skin overexposed to the sun (Yamauchi et al, 1991). Moreover, a solarium has the potential to increase the risk of skin diseases (Freeman et al, 1970;Kelfkens et al, 1990). The skin normally gets thinner with age and takes on an atrophic appearance, whereas skin exposed to the sun thickens due to the accumulation of elastotic material, develops a coarse and a papular appearance, and becomes inelastic.…”

mentioning

confidence: 99%

Cutaneous cell and extracellular matrix responses to ultraviolet-B irradiation

1996

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The present study examined fibroblasts and keratinocytes in monolayers and cultured within dermal and skin substitutes and their use in assessing the effect of UVB irradiation on cutaneous cells and extracellular matrix organization. Dermal substitutes (DS) were produced by incorporating normal fibroblasts into a collagen lattice and skin substitutes (SS) were obtained by seeding normal keratinocytes onto the DS. Keratinocyte monolayers, fibroblast monolayers, DS, and SS were exposed once a day to a UVB source (10 mJ/cm2). The irradiation protocol was stopped when the keratinocytes of the non-irradiated cultures (control groups) had reached confluence. Microscopic observations revealed that UVB radiation decreased both fibroblast and keratinocyte growth and enhanced their differentiation resulting in (1) less fibroblasts in the DS and SS, and (2) incomplete coverage of the DS by keratinocytes. Microscopic observations and histological analyses revealed major morphological changes. Both cell types became bigger and presented wide nuclei and vacuoles in the cytoplasm. No organized deep epidermal layer was observed in irradiated compared to non-irradiated SS. Irradiated DS and SS extracellular matrices showed an irregular aggregating collagen fiber organization with serious discrepancies suggesting large defects in the structural properties of the extracellular matrix. The present study demonstrated that exposure to a UVB source led to profound morphological and functional disturbances in both cutaneous cells and in the extracellular matrices of the DS and SS. The present technology would be of great interest for step-by-step studies of UVR effects on cutaneous cell morphology and functional properties, and could be an alternative to using animals for pharmacological and toxicological evaluations.

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Ultraviolet Wavelength Factors in Solar Radiation and Skin Cancer

Cited by 31 publications

References 6 publications

Prior Exposure of Human Cells to Near Uv‐radiation Gives a Decrease in the Amount of the Unscheduled Dna‐synthesis Induced by Far Uv‐radiation

Prior Exposure of Human Cells to Near Uv‐radiation Gives a Decrease in the Amount of the Unscheduled Dna‐synthesis Induced by Far Uv‐radiation

Experimental Ultraviolet Light-Carcinogenesis

Cutaneous cell and extracellular matrix responses to ultraviolet-B irradiation

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