Ultrawide Angle Fluorescein Angiographic Imaging: A Comparison to Conventional Digital Acquisition Systems

Friberg, Thomas R.; Gupta, Anurag; Yu, Jenny Y.; Huang, Lei; Suñer, Iván J.; Puliafito, Carmen A.; Schwartz, Steven D.

doi:10.3928/15428877-20080701-06

Cited by 75 publications

(57 citation statements)

References 8 publications

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“…2). Multiple studies in DR have reported that UWF FA was superior to the seven-standard fields in demonstrating angiographic abnormalities [17,29,30]. Wessel et al [30] reported that UWF FA displayed 3.9 times more nonperfusion, 1.9 times more neovascularization, and 3.8 times more panretinal photocoagulation compared with a simulated 7-field overlay.…”

Section: Clinical Applications Of Ultra-widefield Imaging Diabetic Rementioning

confidence: 99%

“…Ultra-widefield FA is available in the Optos system since the P200A model provides a high-resolution wide-angle angiographic module. Single capture using a 488-nm laser with a 500-nm barrier filter enables angiographic view of peripheral vascular structure, including perfusion status, leakage, and staining, which can be missed on the seven-standard fields of the Early Treatment Diabetic Retinopathy Study [17][18][19][20]. ICGA was recently added to the multimodal capabilities of the Optos.…”

Section: Ultra-widefield Imaging Modalitiesmentioning

confidence: 99%

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Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

Lee

Sagong

2016

J Retin

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The peripheral retina is frequently affected by various diseases and ultra-widefield (UWF) imaging has become an essential tool for evaluation of peripheral retinal pathology. The wide angle and high resolution of this imaging device were recently updated along with multimodal capabilities, including pseudocolor fundus photographs, fluorescein and indocyanine green angiography, and autofluorescence images. Using this UWF technology, important clinical observations have been made in the normal population and patients with certain diseases including diabetic retinopathy, retinal vascular occlusion, retinal detachment, uveitis, age-related macular degeneration, and choroidal tumors. Although peripheral distortion and the need for clinical validation are obstacles to overcome for the accurate quantification and more generalized use, UWF imaging has provided new insights into a variety of disorders and has become the standard-ofcare imaging modality for many diseases. Therefore, use of UWF retinal imaging for the daily retina practice in the near future is inevitable. This review will describe the principles of UWF technologies with several modalities, and include its clinical applications and then suggest future directions.

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Section: Clinical Applications Of Ultra-widefield Imaging Diabetic Rementioning

confidence: 99%

Section: Ultra-widefield Imaging Modalitiesmentioning

confidence: 99%

Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

Lee

Sagong

2016

J Retin

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“…Fluorescein angiographic studies of the mid- and far-periphery of diabetic patients by Shimizu et al [13,14 ]in the 1980's demonstrated areas of peripheral retinal nonperfusion in diabetic patients. These findings have been reproduced and substantiated more recently utilizing a novel, commercially available imaging system for ultrawide-field fluorescein angiography (UWFA) that employs a scanning laser ophthalmoscope and an ellipsoidal mirror [15,16]. …”

Section: Introductionmentioning

confidence: 99%

RaScaL: A Pilot Study to Assess the Efficacy, Durability, and Safety of a Single Intervention with Ranibizumab plus Peripheral Laser for Diabetic Macular Edema Associated with Peripheral Nonperfusion on Ultrawide-Field Fluorescein Angiography

Suñer

Peden²,

Hammer³

et al. 2014

Ophthalmologica

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Background and Objectives: To determine the efficacy, durability, and safety of a single treatment with intravitreal ranibizumab plus peripheral scatter laser (RaScaL) in patients with diabetic macular edema associated with peripheral retinal nonperfusion on ultrawide-field fluorescein angiography (UWFA). Study Design: A 6-month, randomized, controlled, prospective phase I/II study of 30 treatment-naïve eyes of 22 patients (8 bilateral patients) with visual impairment secondary to diabetic macular edema associated with peripheral nonperfusion on UWFA. Patients were randomized to receive ranibizumab plus UWFA-guided peripheral scatter laser (n = 15) or triamcinolone acetonide plus macular laser (n = 15). Results: At 6 months, the RaScaL group patients had fewer recurrences warranting retreatment (33% vs. 80%, p < 0.003). Mean change in final visual acuity and central foveal thickness were not statistically significant between groups. Conclusion: This pilot study suggests the efficacy, safety and durability of the RaScaL treatment regimen in patients with diabetic macular edema associated with peripheral nonperfusion on UWFA.

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“…Second, it is among the first to utilize Optos fluorescein angiography for automated retinal imaging analysis. The medical benefit of this modality has been well documented [3] [4] [5] and its use is becoming part of standard care in many centers.…”

Section: Introductionmentioning

confidence: 99%

Towards automatic detection of abnormal retinal capillaries in ultra-widefield-of-view retinal angiographic exams

Zutis

Trucco

Hubschman³

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Abstract-Retinal capillary abnormalities include small, leaky, severely tortuous blood vessels that are associated with a variety of retinal pathologies. We present a prototype imageprocessing system for detecting abnormal retinal capillary regions in ultra-widefield-of-view (UWFOV) fluorescein angiography exams of the human retina. The algorithm takes as input an UWFOV FA frame and returns the candidate regions identified. An SVM classifier is trained on regions traced by expert ophthalmologists. Tests with a variety of feature sets indicate that edge features and allied properties differentiate best between normal and abnormal retinal capillary regions. Experiments with an initial set of images from patients showing branch retinal vein occlusion (BRVO) indicate promising area under the ROC curve of 0.950 and a weighted Cohen's Kappa value of 0.822.

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Ultrawide Angle Fluorescein Angiographic Imaging: A Comparison to Conventional Digital Acquisition Systems

Abstract: A prototype ultrawide angle imaging system displayed significantly more diabetic retinal pathology in a single image than conventional systems.

Cited by 75 publications

References 8 publications

Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

RaScaL: A Pilot Study to Assess the Efficacy, Durability, and Safety of a Single Intervention with Ranibizumab plus Peripheral Laser for Diabetic Macular Edema Associated with Peripheral Nonperfusion on Ultrawide-Field Fluorescein Angiography

Towards automatic detection of abnormal retinal capillaries in ultra-widefield-of-view retinal angiographic exams

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