Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model

Lee, Bombi; Yeom, Mijung; Shim, Insop; Lee, Hyejung; Hahm, Dae‐Hyun

doi:10.1007/s11418-019-01373-w

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…Based on their results, umbelliferone at the doses of 20, 40, or 60 mg/kg (intraperitoneal injection, once a day for 2 weeks) markedly showed anti‐depressive effects compared to the positive group (10 mg/kg). It increased the 5‐HT level (B. Lee et al, 2020). Plus, an in‐silico study confirmed that umbelliferone derivatives possess neuroprotective effects via inhibiting MAO activities (Seong et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

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Pharmacogenetic‐based management of depression: Role of traditional Persian medicine

Jalali

Firouzabadi

Zarshenas

2021

Phytotherapy Research

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Depression is one of the most common mental disorders worldwide. The genetic factors are linked to depression and anti‐depressant outcomes. Traditional Persian medicine (TPM) manuscripts have provided various anti‐depressant remedies, which may be useful in depression management. This review has studied the bioactive compounds, underlying mechanisms, and treatment outcomes of the medicinal plants traditionally mentioned effective for depression from “The storehouse of medicament” (a famous pharmacopeia of TPM) to merge those with the novel genetics science and serve new scope in depression prevention and management. This review paper has been conducted in two sections: (1) Collecting medicinal plants and their bioactive components from “The storehouse of medicament,” “Physician's Desk Reference (PDR) for Herbal Medicines,” and “Google scholar” database. (2) The critical key factors and genes in depression pathophysiology, prevention, and treatment were clarified. Subsequently, the association between bioactive components' underlying mechanism and depression treatment outcomes via considering polymorphisms in related genes was derived. Taken together, α‐Mangostin, β‐carotene, β‐pinene, apigenin, caffeic acid, catechin, chlorogenic acid, citral, ellagic acid, esculetin, ferulic acid, gallic acid, gentiopicroside, hyperoside, kaempferol, limonene, linalool, lycopene, naringin, protocatechuic acid, quercetin, resveratrol, rosmarinic acid, and umbelliferone are suitable for future pharmacogenetics‐based studies in the management of depression.

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Section: Resultsmentioning

confidence: 99%

“…Based on their results, umbelliferone at the doses of 20, 40, or 60 mg/kg (intraperitoneal injection, once a day for 2 weeks) markedly showed anti-depressive effects compared to the positive group (10 mg/kg). It increased the 5-HT level (B Lee et al, 2020)…”

mentioning

confidence: 99%

Pharmacogenetic‐based management of depression: Role of traditional Persian medicine

Jalali

Firouzabadi

Zarshenas

2021

Phytotherapy Research

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“…Hence, this article summarizes natural products with antidepressant effects. The results showed that Umbelliferae had the highest frequency of occurrence and may be the main source of antidepressant natural products, such as ferulic acid [33][34][35][36], umbelliferone [46][47][48][49], and apigenin [135][136][137].…”

Section: Discussionmentioning

confidence: 99%

“…As for depression, this compound can significantly improve CUMS-induced depressive behaviors, including lack of pleasure and prolonged immobility. It can inhibit the activity of MAO and lower the elimination of 5-HT [46]. Interestingly, many of its derivatives also are good MAO inhibitors [47].…”

Section: Compounds Regulating Monoaminementioning

confidence: 99%

"Natural Compounds and Depressive Disorder: A Review Highlighting Botanical Sources and Reaction Mechanisms"

Wang

2021

BJSTR

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Depressive disorder is a typical mental illness characterized by depressed mood and anhedonia, with a great burden to patients and society. Currently, only a small minority of medicines are efficient in the clinic with high prices and various adverse reactions, including sleep disorders and gastrointestinal reactions. To develop new antidepressants, pharmacists have gradually turned their attention to phytochemicals, especially those from traditional Chinese medicine (TCM). Natural products could be good candidates for developing effective drugs and valid therapeutic strategies. In this article, we reviewed more than 20 natural compounds from TCMs with protective action against the depressive disorder, and their reaction mechanisms were reviewed from four aspects: reversing neurotransmitter imbalance, maintaining neuroendocrine homeostasis, alleviating synaptic plasticity dysfunction, and inhibiting neuroinflammation.

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“…Moreover, UMB also decreased the serum CORT levels and modulated the serotonin system in the hippocampus and amygdala. In addition, it increased the dopamine levels in the hippocampus [ 110 ].…”

Section: Effects Of Herbal Medicines On Ptsd Via Amelioration Of Dist...mentioning

confidence: 99%

Nutraceutical Interventions for Post-Traumatic Stress Disorder in Animal Models: A Focus on the Hypothalamic–Pituitary–Adrenal Axis

2022

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Post-traumatic stress disorder (PTSD) occurs after exposure to traumatic events and is characterized by overwhelming fear and anxiety. Disturbances in the hypothalamic–pituitary–adrenal (HPA) axis are involved in the pathogenesis of mood disorders, including anxiety, PTSD, and major depressive disorders. Studies have demonstrated the relationship between the HPA axis response and stress vulnerability, indicating that the HPA axis regulates the immune system, fear memory, and neurotransmission. The selective serotonin reuptake inhibitors (SSRIs), sertraline and paroxetine, are the only drugs that have been approved by the United States Food and Drug Administration for the treatment of PTSD. However, SSRIs require long treatment times and are associated with lower response and remission rates; therefore, additional pharmacological interventions are required. Complementary and alternative medicine therapies ameliorate HPA axis disturbances through regulation of gut dysbiosis, insomnia, chronic stress, and depression. We have described the cellular and molecular mechanisms through which the HPA axis is involved in PTSD pathogenesis and have evaluated the potential of herbal medicines for PTSD treatment. Herbal medicines could comprise a good therapeutic strategy for HPA axis regulation and can simultaneously improve PTSD-related symptoms. Finally, herbal medicines may lead to novel biologically driven approaches for the treatment and prevention of PTSD.

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Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model

Cited by 12 publications

References 33 publications

Pharmacogenetic‐based management of depression: Role of traditional Persian medicine

Pharmacogenetic‐based management of depression: Role of traditional Persian medicine

"Natural Compounds and Depressive Disorder: A Review Highlighting Botanical Sources and Reaction Mechanisms"

Nutraceutical Interventions for Post-Traumatic Stress Disorder in Animal Models: A Focus on the Hypothalamic–Pituitary–Adrenal Axis

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