Umbilical Cord Anomalies and Antenatal Fetal Deaths

Clausen, Ingo

doi:10.1097/00006254-198912000-00002

Cited by 47 publications

(23 citation statements)

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“…The umbilical cord plays an important role in the intrauterine development by assuring blood flow between the fetus and the placenta [1,2]. Wharton's jelly is an external cover of the umbilical vessels.…”

Section: Introductionmentioning

confidence: 99%

The Activity of Collagen-Degrading Enzymes of Wharton’s Jelly in EPH Gestosis (Pre-Eclampsia)

Sobolewski

Galewska²,

Wolańska³

et al. 2001

Neonatology

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Oedema/proteinuria/hypertension (EPH) gestosis is one of the more common complications observed during pregnancy. Our previous studies demonstrated some qualitative and quantitative changes in the extracellular matrix of Wharton’s jelly in newborns delivered by mothers with EPH gestosis. For this reason it was decided to evaluate the effect of EPH gestosis on the activity of gelatinolytic and proteolytic enzymes which may be involved in collagen degradation in Wharton’s jelly. Zymographic analysis of control and EPH gestosis samples of Wharton’s jelly demonstrates different electrophoretic patterns of gelatinolytic enzymes. The control Wharton’s jelly contains two latent forms of gelatinolytic enzymes: gelatinase A [metalloproteinase (MMP)-2, 72 kD] and gelatinase B (MMP-9, 92 kD). In contrast to control tissue, the main gelatinolytic enzyme of EPH gestosis Wharton’s jelly is gelatinase A (MMP-2). It was found that the proteolytic activity in EPH gestosis Wharton’s jelly differs from control. The decrease in gelatinase activity may be one of the factors which promote the accumulation of collagen in this tissue.

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Section: Introductionmentioning

confidence: 99%

The Activity of Collagen-Degrading Enzymes of Wharton’s Jelly in EPH Gestosis (Pre-Eclampsia)

Sobolewski

Galewska²,

Wolańska³

et al. 2001

Neonatology

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“…This structure gives elasticity to the umbilical cord so that the main function of Wharton's jelly is the protection of the umbilical blood vessels, neutralizing the external pressure influence on blood flow between placenta and fetus (4) . Structural abnormalities of the umbilical cord are conditions increasingly recognized, in literature, as being associated with fetal death in utero (3,9,11) . Sun et al (1995) (9) studied 25 cases of fetal death associated with structural abnormalities of the umbilical cord which revealed that there was no correlation between these causes of fetal death and the age of the pregnant women, their health or the obstetric history (2,9) .…”

Section: Discussionmentioning

confidence: 99%

“…These structural changes are strongly associated with intrauterine growth restriction, fetal death and increased rates of cesarean delivery (2,3,9) .…”

Section: Discussionmentioning

confidence: 99%

Absence of Wharton’s jelly: case report

Oliveira¹,

Düfloth²,

Coelho³

2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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There are few reports in the literature of the absence of Wharton's Jelly. Here we report the seventh case in a primigravida, 22 years old, admitted after vaginal delivery of stillborn. The umbilical cord have a long segment with disruption of cord structures and the three blood vessels were completely separated from each other, with a minimum amount of Wharton's jelly remaining around each vessel. The absence of Wharton' jelly is associated with fetal distress, intrauterine growth restriction, and fetal death. Quantitative/qualitative studies of Wharton's jelly represent an open field of research for possible correlations with obstetric conditions and fetal deaths.

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“…A true umbilical cyst, which has epithelial cells, is either remnants of the omphalomesenteric duct, the allantois, amniotic inclusions, or neoplasms, such as hemangiomas and teratomas [11] . A pseudocyst is a cavity having no epithelial lining.…”

Section: Discussionmentioning

confidence: 99%

Umbilical Cord Cysts of Allantoic and Omphalomesenteric Remnants with Progressive Umbilical Cord Edema: A Case Report

Kita¹,

Kikuchi²,

Miyashita

et al. 2009

Fetal Diagn Ther

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We present a unique case of umbilical cord cysts of allantoic and omphalomesenteric remnants with progressive cord edema during pregnancy. Enlargement of the umbilical cord was observed initially at 28 weeks’ gestation; the cord cysts were first recognized at 17 weeks. At 37 weeks, a cesarean section was performed and a male infant weighing 2,300 g was delivered. The entire length of the umbilical cord was 80 cm; the 50-cm proximal portion was strikingly edematous and was 7 cm in diameter. On the 1st day of life, operative exploration was undertaken via an infraumbilical incision. It was evident that a patent urachus protruded from the bladder. The lesion was excised and the bladder was closed in a two-layer anastomosis. Histologically, the intestinal epithelium was connected to the transitional epithelium at the top of the urachus, indicating allantoic remnants fused with omphalomesenteric remnants. Such a case has not been reported previously. It was considered that the overflow of urine from allantoic remnants to omphalomesenteric remnants caused the extraordinary edema of the umbilical matrix. Based on our experience, finding progressive umbilical cord edema may indicate a patent urachus co-existing with allantoic and omphalomesenteric remnants.

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Umbilical Cord Anomalies and Antenatal Fetal Deaths

Cited by 47 publications

References 0 publications

The Activity of Collagen-Degrading Enzymes of Wharton’s Jelly in EPH Gestosis (Pre-Eclampsia)

The Activity of Collagen-Degrading Enzymes of Wharton’s Jelly in EPH Gestosis (Pre-Eclampsia)

Absence of Wharton’s jelly: case report

Umbilical Cord Cysts of Allantoic and Omphalomesenteric Remnants with Progressive Umbilical Cord Edema: A Case Report

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