Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery

Seong, Won Joon; Yoon, Douk Hun; Chong, Gun Oh; Hong, Dae Gy; Koo, Tae Bon; Lee, Taek Hoo; Chun, Sang Sik

doi:10.1007/s00404-009-1253-3

Cited by 20 publications

(21 citation statements)

References 21 publications

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“…Based on the umbilical cord blood analysis, Won Joon et al concluded that stressful intrauterine environment may stimulate fetuses to synthesize NT-proBNP. According to the same authors, vaginal delivery is not associated with an increase in umbilical cord blood NT-proBNP levels and consequently, does not promote a fetal cardiac stress [ 35 ].In our present study, serum concentration of NT-proBNP did not show significant associations with parity and route of delivery. Moreover, NT-proBNP levels were not modulated by participants’ age, gestational age at delivery, birth weight and pH of the umbilical cord blood.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Clinical Assessment of NT-proBNP as a Diagnostic Tool for Preeclampsia, Gestational Hypertension and Gestational Diabetes Mellitus

2016

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Common complications of pregnancy include preeclampsia (PE), gestational hypertension (GH) and gestational diabetes mellitus (GDM). Hypertensive disorders (PE/GH) and GDM may result in greater maternal, fetal and neonatal morbidity and mortality. Women with PE/GH, one of the most common causes of heart burden in an obstetrical setting, present with elevated serum levels of BNP and NT-proBNP. The aim of this study was to shed more light on the role of NT-proBNP in pathophysiology of PE, GH and GDM. The study included 156 pregnant women with singleton pregnancies. A total of 26 women developed arterial hypertension during pregnancy, 14 were diagnosed with PE, and GDM was detected in 81 patients. The control group included 35 women with uncomplicated pregnancies, normal arterial blood pressure and normal glucose concentrations. Patients with GH presented with significantly higher serum concentrations of NT-proBNPthan normotensive women (65.5 vs. 37.4 pg/ml; p = 0.0136). Serum levels of NT-proBNP in patients with PE were the highest of all the analyzed subsets, being significantly higher than in women without this condition (89.00 vs. 37.4pg/ml,p = 0,0136). However, women with and without GDM did not differ significantly in terms of their serum NT-proBNPconcentrations. Serum NT-proBNP (pg/ml) (p = 0.0001) and BMI (p<0.0001) turned out to be independent predictors of GH on multivariate logistic regression analysis.Moreover, serum NT-proBNP (pg/ml) was identified as an independent indicator of PE (p = 0.0016). A significant inverse correlation was found between birth weight and maternal serum NT-proBNP concentrations. In our opinion, NT-proBNP can be a useful clinical marker of GH and PE. Determination of NT-proBNP levels may be helpful in identification of patients with PE and GH and in their qualification for intensive treatment; this in turn, may be reflected by better neonatal outcomes.

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Section: Discussionmentioning

confidence: 99%

Prenatal Clinical Assessment of NT-proBNP as a Diagnostic Tool for Preeclampsia, Gestational Hypertension and Gestational Diabetes Mellitus

2016

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“…Compared with term pregnancy, NT‐proBNP concentrations were higher during earlier stages of gestation (mean, 1998 ng/L; median, 1874 ng/L; 95% CI, 242–3754 ng/L) (Figure ). The decrease with advancing gestation has also been confirmed for umbilical cord blood samples. It may be the consequence of myocardial maturation, which includes an increase in compliance and relaxation time, a decrease in afterload and an improvement in systolic function.…”

Section: Natriuretic Peptides: Fetal and Neonatal Physiology And Metamentioning

confidence: 59%

“…Bar‐Oz et al . and Seong et al . did not find an association between mode of delivery and umbilical cord blood NT‐proBNP concentration, while Fortunato et al .…”

Section: Natriuretic Peptides: Fetal and Neonatal Physiology And Metamentioning

confidence: 90%

Old tool – new application: NT‐proBNP in fetal medicine

Merz

Gembruch

2014

Ultrasound in Obstet & Gyne

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“…BNP and NT-proBNP concentrations rise at birth in normal healthy infants, level off at 3-4 d, and then fall steadily to stable but low levels in infancy (12,16). In several studies, the method of delivery of the newborn did not influence natriuretic peptide levels (17,18). However, Fortunato et al reported that NT-proBNP was significantly higher in infants delivered by elective cesarean section than in infants delivered after spontaneous birth.…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

“…Fetal myocardial compromise resulted in a distribution of cardiac output toward the left ventricle and a rise in the right-ventricular afterload, explaining the increase in ANP (38). Seong et al, in a study to evaluate the relationship between NT-proBNP levels and the method of delivery, found that infants with low Apgar scores and low umbilical cord blood pH appeared to have increased levels of NT-proBNP (18). Elevation in cardiac troponin levels is much less common in the perinatal period.…”

Section: Clinical Indicationsmentioning

confidence: 99%