Umbilical cord blood banking: from personal donation to international public registries to global bioeconomy

Petrini, Carlo

doi:10.2147/jbm.s64090

Cited by 34 publications

(55 citation statements)

References 69 publications

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“…Although public CBBs supply the overwhelming majority of CBUs that are actually transplanted, private CBBs still play a significant role in the system because they collect, process, and bank more than half of all CBUs in the world. 143 Furthermore, despite having a lower rate of transplantation, the private family banking market depends on and contributes to most of the same infrastructure that public CBBs require. For example, a representative of a private CBB shared about supporting education and outreach programs that also benefit public CBBs.…”

Section: Private(banks((mentioning

confidence: 99%

Challenges to the Sustainability of the U.S. Public Cord Blood System

Kapinos¹,

Briscombe²,

Gračner³

et al. 2017

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Section: Private(banks((mentioning

confidence: 99%

Challenges to the Sustainability of the U.S. Public Cord Blood System

Kapinos¹,

Briscombe²,

Gračner³

et al. 2017

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“…64 In Spain, for example, public banks will store UCB for autologous use, but only if it is also available if requested on behalf of an unrelated patient. 65 A survey of potential Swiss donors revealed that 49% would accept a hybrid private/public model. 66 In Australia, recruitment to clinical trials of autologous UCBT has been influenced by differences in policy between public and family banks.…”

Section: Ethical Considerationsmentioning

confidence: 99%

Umbilical cord blood donation: public or private?

Ballen

Verter²,

Kurtzberg

2015

Bone Marrow Transplant

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Umbilical cord blood (UCB) is a graft source for patients with malignant or genetic diseases who can be cured by allogeneic hematopoietic cell transplantation (HCT), but who do not have an appropriately HLA-matched family or volunteer unrelated adult donor. Starting in the 1990s, unrelated UCB banks were established, accepting donations from term deliveries and storing UCB units for public use. An estimated 730 000 UCB units have been donated and stored to date and ∼ 35 000 UCB transplants have been performed worldwide. Over the past 20 years, private and family banks have grown rapidly, storing ∼ 4 million UCB units for a particular patient or family, usually charging an up-front and yearly storage fee; therefore, these banks are able to be financially sustainable without releasing UCB units. Private banks are not obligated to fulfill the same regulatory requirements of the public banks. The public banks have released ∼ 30 times more UCB units for therapy. Some countries have transitioned to an integrated banking model, a hybrid of public and family banking. Today, pregnant women, their families, obstetrical providers and pediatricians are faced with multiple choices about the disposition of their newborn's cord blood. In this commentary, we review the progress of UCB banking technology; we also analyze the current data on pediatric and adult unrelated UCB, including the recent expansion of interest in transplantation for hemoglobinopathies, and discuss emerging studies on the use of autologous UCB for neurologic diseases and regenerative medicine. We will review worldwide approaches to UCB banking, ethical considerations, criteria for public and family banking, integrated banking ideas and future strategies for UCB banking.

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“…[4] However, it is imperative to reminder that the donations are made voluntarily. [5,6] Each individual has one chance in a lifetime to save one's own UCB. Accordingly, this requires nurses who are working at the delivery room to collect high-quality UCB units, consequently improving the chances of future lifesaving.…”

Section: Introductionmentioning

confidence: 99%

Maternal and neonatal predictive variables for quality of cord blood as a source of stem cells

Marzouk

Abd-Allah²

2018

JNEP

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Objective: This study aimed to identify the maternal and neonatal predictive variables for quality of cord blood as a source of stem cells. Methods: A descriptive design was followed in this study. A purposive sample of 143 pairs; pregnant women assigned for elective cesarean section and their newborns, was enrolled in current study. The subjects were recruited from the Operating Theater of Mansoura University Hospital, Egypt. One hundred forty three umbilical cord blood units were collected in utero from cesarean deliveries. The collected units were assessed for its blood volume and total nucleated cells content. An assessment sheet of 12 items was used as a tool of data collection. Results: The greater blood volume and higher nucleated cells obtained from the primigravida, between 37 to 40 gestation weeks, and those not exposed to cigarette smoke during pregnancy (163.1 ± 24.8 ml and 10.2 ± 2.8 × 10 6 cells/ml, 169.3 ± 22.6 ml and 11.2 ± 1.9 × 10 6 cells/ml, 169.8 ± 21.4 ml and 10.0 ± 2.9 × 10 6 cells/ml respectively). The birth weight ≥ 3,600 g, the first born baby, and the heavier placenta (≥ 550 g) produced significantly greater blood volume and cellular content (161.5 ± 20.6 ml and 9.8 ± 2.4 × 10 6 cells/ml, 164.6 ± 19.4 ml and 9.6 ± 2.7 cells/ml, 164.8 ± 19.6 ml and 10.2 ± 2.6 × 10 6 cells/ml respectively). Conclusions: Primigravida, delivery between 37 to 40 gestation weeks, and no exposure to cigarette smoke during pregnancy were the maternal variables that were associated with larger blood volume and higher cellular content. Even though, first born baby, birth weight ≥ 3,600 g, and placenta weight ≥ 550 g were the neonatal variables.

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Umbilical cord blood banking: from personal donation to international public registries to global bioeconomy

Cited by 34 publications

References 69 publications

Challenges to the Sustainability of the U.S. Public Cord Blood System

Challenges to the Sustainability of the U.S. Public Cord Blood System

Umbilical cord blood donation: public or private?

Maternal and neonatal predictive variables for quality of cord blood as a source of stem cells

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