Umbilical cord blood collection: do patients really understand?

Fox, Nathan S.; Stevens, Cladd E.; Ciubotariu, Rodica; Rubinstein, Pablo; McCullough, Laurence B.; Chervenak, Frank A.

doi:10.1515/jpm.2007.084

Cited by 57 publications

(61 citation statements)

References 21 publications

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“…Although the media, family and friends do play a role since public interest in UCB donation is growing, the fact that healthcare professionals addressed the UCB donation in 60% of the cases shows how important the role of the obstetrician or primary caregiver is. This is supported by other studies, which show that doctors need to address the topic and need to guide the expectant couple in the decision-making process to ensure the receipt of balanced and good quality information [14,15]. Based on our data, public UCB banks would miss more than half of their donors if couples were not actively asked for UCB donation by the physician.…”

Section: Discussionsupporting

confidence: 81%

Controversies in hybrid banking: attitudes of Swiss public umbilical cord blood donors toward private and public banking

Manegold

Meyer-Monard

Thewis

et al. 2010

Arch Gynecol Obstet

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Purpose Umbilical cord blood (UCB) stored in public inventories has become an alternative stem cell source for allogeneic stem cell transplantation. The potential use of autologous UCB from private banks is a matter of debate. In the face of the limited resources of public inventories, a discussion on ''hybrid'' public and private UCB banking has evolved. We aimed to explore the attitudes of the donating parents toward public and private UCB banking. Study design and methods A standardized, anonymous questionnaire was sent to the most recent 621 public UCB donors including items regarding satisfaction with recruitment process, the need for a second consent before release of the UCB unit for stem cell transplantation, and the donors' views on public and private UCB banking. Furthermore, we asked about their views on UCB research. Results Of the questionnaires, 48% were returned, and 16% were lost due to mail contact. Of our donors, 95% would donate to the public bank again. As much as 35% of them were convinced that public banking was useful. Whereas 27% had never heard about private UCB banking, 34% discussed both options. Nearly 70% of donors opted for public banking due to altruism and the high costs of private banking. Of our public UCB donors, 81% stated that they did not need a re-consent before UCB release for stem cell transplantation. In case of sample rejection, 53.5% wanted to know details about the particular research project. A total of 9% would not consent. Conclusions Almost all donors would choose public banking again due to altruism and the high costs of private banking. Shortly after donation, mail contact with former UCB donors was difficult. This might be a relevant issue in any sequential hybrid banking.

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Section: Discussionsupporting

confidence: 81%

Controversies in hybrid banking: attitudes of Swiss public umbilical cord blood donors toward private and public banking

Manegold

Meyer-Monard

Thewis

et al. 2010

Arch Gynecol Obstet

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“…In the last few years, a number of studies have tried to identify which factors may influence this social behaviour, focusing on perspective or retrospective decision making processes [5][6][7][8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Most of them have focused on the need to understand motivations to donate cord blood or to refuse it, others have analysed the reasons to prefer private to public banking [5][6][7][8][9][10][11][12][13]. In particular, Surbek et al [5] and Fernandez et al [6] analysed retrospective and prospective decision making processes related to cord blood donation respectively.…”

Section: Introductionmentioning

confidence: 99%

An analysis of decision making in cord blood donation through a participatory approach

Salvaterra

Casati

Bottardi

et al. 2010

Transfusion and Apheresis Science

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a b s t r a c tWe analysed knowledge, comprehension, opinions, attitudes and choices related to cord blood donation in seven heterogeneous focus groups including pregnant women, future parents, cord blood donors, midwives and obstetricians/gynaecologists. Comparative evaluations focused on attitudes before versus after delivery and preferences of public versus private banking. The study outlined large support to altruistic cord blood donation and need for better health professionals education in this field. Collected information was presented in a public conference and used to develop an informative brochure which was tested for readability and clearliness in four workshops and finally distributed to 26 regional delivery suites.

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“…Consequently, cord blood stem cells require less rigorous antigen tissue matching for transplants than bone marrow stem cells [17]. Research indicates that a mismatch of up to two antigen sites still provides successful clinical outcomes [18,1]. In fact, researchers report that the rate of rejection for cord blood stem cell transplants is half the rate of rejection for bone marrow transplants.…”

Section: Advantages Of Cord Blood Bankingmentioning

confidence: 99%

“…This blood is called umbilical cord blood. Umbilical cords have traditionally been viewed as disposable biological by-product [1]. Cord blood banking is a process by which after the delivery of the baby, the cord blood is collected from the umbilical cord.…”

Section: Introductionmentioning

confidence: 99%

Cord Blood Banking: The Prospects and Challenges of Implementation in Nigeria

AO¹

2017

HTIJ

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From time immemorial, umbilical cord blood has been regarded as a waste product that has been discarded along with the placenta. It is now known to contain potentially life-saving hematopoietic-progenitor stem cell that has been used successfully as an alternative allogeneic donor source to treat a variety of pediatric genetic, hematologic, immunologic, and oncologic disorders. Stem cells from umbilical cord blood also offers several distinct advantages over bone marrow or peripheral stem cells; hence the need to bank it. These scientific advances have resulted in the establishment of not-for-profit (public) and forprofit (private) cord blood-banking programs for allogeneic and autologous cord blood transplantation. Recently, cord blood cells are used for cellular therapy and regenerative medicine as an alternative natural source of treatment. Advantages of umbilical cord blood stem cells over bone marrow stem cells for transplants include: ease of collection; reduced risk of transmission of infection; reduced processing time; and rejection of samples etc. However, cord blood is disadvantaged in that the volume collected is fixed and relatively small; engraftment takes longer time and there may be transmission of the rare genetic diseases of the blood or immune system etc. Issues confronting intending institutions are: the policies, ethical issues and the challenges faced. Implementation of cord blood banking in Nigeria as a developing country is challenging due to: finance, religious and traditional beliefs, erratic power supply, lack of awareness of Hematopoietic Stem Cell Transplant, lack of technical expertise etc. The use of Stem cell therapy is advancing in medical research and therefore this would be a major achievement in the medical sector if it is fully implemented in Nigeria.

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Umbilical cord blood collection: do patients really understand?

Abstract: Obstetricians should assume that pregnant women are poorly informed about cord blood banking. The decision making process should be conducted with the goal of ensuring every pregnant woman the opportunity to make a well informed decision about cord blood banking.

Cited by 57 publications

References 21 publications

Controversies in hybrid banking: attitudes of Swiss public umbilical cord blood donors toward private and public banking

Controversies in hybrid banking: attitudes of Swiss public umbilical cord blood donors toward private and public banking

An analysis of decision making in cord blood donation through a participatory approach

Cord Blood Banking: The Prospects and Challenges of Implementation in Nigeria

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