Umbilical Cord Blood Hematopoietic Stem Cell Transplantation, an Alternative to Bone Marrow

Abstract

<p>Umbilical cord blood (UCB) is an alternative hematopoietic stem cell (HSC) source. It is widely applicable for ameliorating several diseases through HSC transplants. One of the few disadvantages of this source of stem cells is the limited amount of HSCs that can be extracted from each cord blood unit (CBU).Single CBU transplantation seems to be more ideal in lower weight, younger patients. Adult clinical studies comparing HSCs from a single CBU and HSCs from bone marrow indicate that umbilical cord blood transplantation is a viable method when a matched bone marrow transplant cannot be identified. Further clinical studies using two CBUs suggest better engraftment and lower risk of relapse. However, double cord blood transplantation has been faced with the challenge of single unit dominance in most studies. <em>Ex vivo</em> expansion of UCB HSC is another promising method to overcome limited HSC counts.</p

Downregulation of circBIRC6 and circCORO1C during differentiation of human cord blood-derived CD34+ cells

“…Hematopoietic stem cell transplantation (HSCT) is a potentially new approach in the treatment of many diseases, including bone marrow (BM) failures and hematologic malignancies (Polak and Bishop 2006). Among all types of bone marrow transplants, umbilical cord blood hematopoietic stem cells (UCB HSCs) transplantation has attracted the attention of many researchers due to the low probability of GVHD and HLA mismatching; however, the use of this resource for adults has been limited due to the inadequate number of CD34 + HSC from any individual donor (Gluckman 2009; Najem and Thu Minn 2011). An appropriate strategy for a successful transplant of UCB HSCs is their proliferation.…”