Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report

Abstract

Background Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy. Case presentation We present a case of a 61-year-old Chinese man with severe progressive supranuclear palsy and treated with umbilical cord blood stem cells transplantation. After the umbilical cord blood stem cells therapy, his neurologic symptoms stopped deteriorating, his muscle rigidity was mildly improved, and he remains alive for more than 8 years. Conclusions Umbilical cord blood stem cells transplantation may be an alternative therapy for patients with severe progressive supranuclear palsy.

Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials

“…The rationale of MSC in PSP is not to replace diseased neurons, but rather to minimize the consequences of neural cell deterioration by using stem cells as treatment [28]. Single-case reports have documented encouraging results with intraarterial autologous adipose tissue-derived MSC [32] and umbilical cord blood stem cell transplantation [33] in patients with PSP.…”