Umbilical cord diameter in the prediction of foetal growth restriction: a cross sectional study

Mohamed, Mariam Lotfy; Elbeily, Magda M.; Shalaby, Maisara M.; Khattab, Yara H.; Taha, Omima T.

doi:10.1080/01443615.2021.2010185

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…In addition, it has been reported that the UC diameter increases significantly with gestational age until the 32 nd -36 th week, and then this value decreases. 4,6,17 In their respective nomograms, Weissman and Jakobi 6 reported this limit as the 36 th week and Raio as the 34 th week. In our research, a statistically significant positive correlation was found between gestational age and UC diameter in all groups.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical Properties of the Umbilical Cord and Its Relationship with Perinatal Outcomes

Kanbay Öztürk,

Çakır Köle,

Çelik

et al. 2024

anajog

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The aim of this study was to determine the elasticity modulus of umbilical cord (UC) using biomechanical tests in diabetic, preeclamptic and control groups and to investigate the relationship with perinatal outcomes.Methods: Patient data from diabetic, preeclamptic and healthy control group women, who gave birth in a single center between September and December 2019 were collected. Prenatal demographic data, pregnancy outcome, and ultrasound Doppler pulsatility index (PI) was obtained. Cord samples were taken at birth and newborn morphometric parameters were measured. The diameter of UCs were measured. The samples then underwent biomechanical testing. By calculating strain and stress, the elasticity modulus of samples were derived.Results: There were thirty subjects in each group. Mean UC radius was significantly greater (p<0.01) in the diabetic group (1.03±0.29 cms) compared to control group (0.86±0.21 cms) and preeclamptic group (0.74±0.14 cms). Median (range) elasticity modulus was highest in the preeclamptic vs. the diabetic and control groups [0.28 (0.22-0.34) vs. 0.12 (0.8-0.30) vs. 0.14 (0.12-0.34), respectively; p<0.01]. Increase in birth week (r=-0.26, p=0.01), birthweight (r=-0.42, p<0.01), newborn height (r=-0.38, p<0.01), and UC diameter (r=-0.78, p<0.01) were all negatively correlated with elasticity modulus. Umbilical artery Doppler PI values had weak positive correlation with elasticity modulus (r=0.21, p=0.4). Conclusion:Morphological, mechanical and histological studies were performed on the UC. It appears that the UC its characteristics are changed in disease processes affecting pregnancy. We believe that if ultrasonographic, histological, biochemical and immunohistochemical data are combined with biomechanical data, larger serial studies may provide new parameters with which we can evaluate fetal well-being based on UC characteristics.

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Section: Discussionmentioning

confidence: 99%

Biomechanical Properties of the Umbilical Cord and Its Relationship with Perinatal Outcomes

Kanbay Öztürk,

Çakır Köle,

Çelik

et al. 2024

anajog

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Nonlinear Regression on Growth Curves for Placental Parameters in R

Lemos,

Braga,

Nogueira

2024

Communications in Computer and Information Science

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Growth charts play a crucial role in the evaluation and surveillance of paediatric populations, serving as indispensable tools for paediatricians and public health researchers. The development of these growth charts for fetal parameters has been extensively used in recent decades. However, investigation of placental parameters and their relationship with obstetric outcome has been relatively neglected, resulting in a significant gap in understanding their biological significance. This study presents an alternative approach for constructing reference growth curves specific to the placental parameter, Diameter 2. Our methodology uses the generalized additive models for location, scale, and shape (GAMLSS), offering distinct advantages over traditional quantile regression methods. One of the key advantages of GAMLSS is its flexibility to accommodate any statistical distribution, allowing for the modelling of various parameters that characterize the distribution of the response variable. Through the application of our proposed methodology, we demonstrated that by using P-splines as a smoothing function and Box-Cox t (BCT) as a distribution, we can achieve a representative growth curve for the Diameter 2 of the placenta throughout gestational age (GA). The resulting models demonstrated high representativeness, with $$R^2$$ R 2 values of 0.7608 and 0.7673 and AIC scores of 7953 and 7946 for the best two models, respectively. Moreover, our approach has the ultimate goal to facilitate early diagnosis of fetal complications, thereby providing valuable assistance to healthcare professionals.

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Umbilical cord diameter in the prediction of foetal growth restriction: a cross sectional study

Cited by 2 publications

References 20 publications

Biomechanical Properties of the Umbilical Cord and Its Relationship with Perinatal Outcomes

Biomechanical Properties of the Umbilical Cord and Its Relationship with Perinatal Outcomes

Nonlinear Regression on Growth Curves for Placental Parameters in R

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