Umbilical cord mesenchymal stem cell‐derived exosomes alleviate collagen‐induced arthritis by balancing the population of Th17 and regulatory T cells

Fu, Yanhong; Li, Jun; Zhang, Ziyu; Ren, Fei; Wang, Yinyin; Jia, Huihui; Liu, Jihe; Chang, Zhijie

doi:10.1002/1873-3468.14460

Cited by 14 publications

(5 citation statements)

References 37 publications

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“…Exosomes released by UC-MSCs restored the balance between Tregs and Th17 in collagen-induced arthritis (CIA) mouse models, simultaneously decreasing the number of Th1 and the concentration of IL-6, IL-17, and TNF-α. Moreover, levels of TGF-β and IL-10 were significantly increased [ 102 ]. Moreover, UC-MSCs inhibit the proliferation and differentiation of Tfh, partially through the secretion of IDO in the presence of IFN-γ at the site of inflammation.…”

Section: Mesenchymal Stromal Cells and T Cellsmentioning

confidence: 99%

The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

Bakinowska,

Bratborska,

Kiełbowski

et al. 2024

Cells

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Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by the formation of a hyperplastic pannus, as well as cartilage and bone damage. The pathogenesis of RA is complex and involves broad interactions between various cells present in the inflamed synovium, including fibroblast-like synoviocytes (FLSs), macrophages, and T cells, among others. Under inflammatory conditions, these cells are activated, further enhancing inflammatory responses and angiogenesis and promoting bone and cartilage degradation. Novel treatment methods for RA are greatly needed, and mesenchymal stromal cells (MSCs) have been suggested as a promising new regenerative and immunomodulatory treatment. In this paper, we present the interactions between MSCs and RA-FLSs, and macrophages and T cells, and summarise studies examining the use of MSCs in preclinical and clinical RA studies.

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Section: Mesenchymal Stromal Cells and T Cellsmentioning

confidence: 99%

The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

Bakinowska,

Bratborska,

Kiełbowski

et al. 2024

Cells

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“…Furthermore, uMSC-Exo appeared to restore the balance between Th17 and Treg cells, which was accompanied by decreased IL-17 and increased TGF-β and IL-10 levels, indicating that uMSC-Exo serves as a crucial regulator of the balance between Th1/Th17 and Treg cells during immune and inflammatory responses. 153,154 Except for Helper T lymphocytes and Treg cells, MSC-Exo could also participate in the differentiation of CTLs. There was a study showed that exosomal PD-L1 suppressed CD8+ T cell numbers in the spleen and peripheral lymph nodes and inhibited cytokine production of CD8+ T cells, indicating that exosome exerts immune inhibitory effects and promotes tissue repair by suppressing T cells differentiate into CD8+ T cells.…”

Section: Msc-exo Regulates T-cell Differentiationmentioning

confidence: 99%

Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation

Zhao¹,

Zhang²,

Li³

et al. 2023

IJN

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Pathological scars are the result of over-repair and excessive tissue proliferation of the skin injury. It may cause serious dysfunction, resulting in psychological and physiological burdens on the patients. Currently, mesenchymal stem cells-derived exosomes (MSC-Exo) displayed a promising therapeutic effect on wound repair and scar attenuation. But the regulatory mechanisms are opinions vary. In view of inflammation has long been proven as the initial factor of wound healing and scarring, and the unique immunomodulation mechanism of MSC-Exo, the utilization of MSC-Exo may be promising therapeutic for pathological scars. However, different immune cells function differently during wound repair and scar formation. The immunoregulatory mechanism of MSC-Exo would differ among different immune cells and molecules. Herein, this review gave a comprehensive summary of MSC-Exo immunomodulating different immune cells in wound healing and scar formation to provide basic theoretical references and therapeutic exploration of inflammatory wound healing and pathological scars.

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“…A particular study highlighted the significant role of HUMSC-Exo in regulating the balance between Th1/Th17 and Treg cells during immune and inflammatory responses, thus reducing the ratio of Th1/Th17 to Treg cells and inhibiting the development of RA. Additionally, HUMSC-Exo may exert a direct influence on macrophage and osteoclast differentiation ( 37 ). In light of these findings, it can be inferred that exosomes derived from HUMSCs have the potential to modulate the equilibrium between pro-inflammatory and anti-inflammatory cells, presenting a promising therapeutic avenue for RA.…”

Section: Exosomes Derived From Mesenchymal Stem Cellsmentioning

confidence: 99%

The impact of exosomes derived from distinct sources on rheumatoid arthritis

et al. 2023

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Rheumatoid arthritis (RA) is an autoimmune disease that can induce joint deformities and functional impairment, significantly impacting the overall well-being of individuals. Exosomes, which are cellularly secreted vesicles, possess favorable biological traits such as biocompatibility, stability, and minimal toxicity. Additionally, they contain nucleic acids, lipids, proteins, amino acids, and metabolites, serving as mediators in cellular communication and information exchange. Recent studies have demonstrated the association between exosomes and the pathogenesis of RA. Exosomes derived from mesenchymal stem cells, dendritic cells, and neutrophils exert influence on the biological functions of immune cells and joint cells, however, the precise mechanism remains largely unclarified. This comprehensive review systematically analyzes and summarizes the biological characteristics and functionalities of exosomes derived from diverse cellular sources, thus establishing a scientific foundation for the utilization of exosomes as diagnostic targets and therapeutic modalities in the context of RA.

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Umbilical cord mesenchymal stem cell‐derived exosomes alleviate collagen‐induced arthritis by balancing the population of Th17 and regulatory T cells

Cited by 14 publications

References 37 publications

The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation

The impact of exosomes derived from distinct sources on rheumatoid arthritis

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