Umbilical Metastasis From Breast Cancer Detected by FDG PET

Basely, M.; Bernard, Philippe; Gisserot, O.; Maszelin, P.; Bussy, E.; Jauréguiberry, Jean-Pierre de

doi:10.1097/rlu.0b013e31819e50cb

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Potential clinical applications of FDG-PET in breast cancer include detection and differentiation of primary breast lesions, staging of axillary lymph nodes, detection of residual and metastatic disease, and monitoring of the response to chemotherapy 29-31. A systematic review and meta-analysis involving 2,460 breast cancer patients resulted in sensitivities ranging from 20 to 100%, and specificities ranging from 65 to 100% 32.…”

Section: Fdgmentioning

confidence: 99%

Metabolic Positron Emission Tomography Imaging in Cancer Detection and Therapy Response

Zhu

Lee

Shim

2011

Seminars in Oncology

301

202

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Positron emission tomography (PET) is a noninvasive imaging technique that provides a functional or metabolic assessment of normal tissue or disease conditions. 18 F-fluorodeoxyglucose PET imaging (FDG-PET) is widely used clinically for tumor imaging due to increased glucose metabolism in most types of tumors, and has been shown to improve the diagnosis and subsequent treatment of cancers. In this chapter, we review its use in cancer diagnosis, staging, restaging, and assessment of response to treatment. In addition, other metabolic PET imaging agents in research or clinical trial stages are discussed, including amino acid analogs based on increased protein synthesis, and choline, which is based on increased membrane lipid synthesis. Amino acid analogs and choline are more specific to tumor cells than FDG, so they play an important role in differentiating cancers from benign conditions and in the diagnosis of cancers with low FDG uptake or high background FDG uptake. For decades, researchers have shown that tumors have altered metabolic profiles and display elevated uptake of glucose, amino acids, and lipids, which can be used for cancer diagnosis and monitoring of the therapeutic response with excellent signalto-noise ratios.Positron Emission Tomography (PET), a noninvasive imaging technique that detects the gamma rays from positron-emitting isotopes has had a major impact on the diagnosis and treatment of disease. PET enables clinicians to view and assess the human body from a functional, biochemical perspective. As a highly sensitive and accurate nuclear medicine imaging technology based on molecular biology, PET has a unique ability to assess the functional and biochemical processes of the body's tissues, which are altered in the earliest stages of virtually all diseases. PET detects these changes -often before anatomical or structural changes have occurred and become evident on magnetic resonance imaging (MRI) or computed tomography (CT). In the 1970's and 1980's, PET was mainly used for research. During the early 1990's, the use of PET expanded into hospitals and diagnostic clinics as more and more medical communities began to realize the utility of PET in clinical applications, particularly in oncology for cancer staging, assessing treatment strategies, and monitoring the effects of therapy with appropriate radiotracers. Reimbursement of studies by Medicare and other third-party payers also contributed significantly to the growth in clinical PET imaging. However, the spatial resolution of PET is not comparable to CT or MRI,

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Section: Fdgmentioning

confidence: 99%

Metabolic Positron Emission Tomography Imaging in Cancer Detection and Therapy Response

Zhu

Lee

Shim

2011

Seminars in Oncology

301

202

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“…4,5 They are commonly caused by gastrointestinal tract and ovarian cancers, but they are seen rarely in uterine carcinoma, lung carcinoma, breast carcinoma, cholangiocarcinoma, and others. 6,7 Sister Mary Joseph nodules can be the presenting feature of a tumor or an early sign of relapse. 8 It is usually associated with widespread intra-abdominal disease.…”

Section: Figurementioning

confidence: 99%

Sister Mary Joseph Nodule in Endometrial Carcinoma

Singh

Sharma²,

Reddy³

et al. 2013

Clinical Nuclear Medicine

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Primary Umbilical Neoplasm Demonstrated on FDG PET/CT

Liu

2011

Clinical Nuclear Medicine

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Primary umbilical neoplasm is very rare, even though there are scattered case reports about the umbilical metastases known as Sister Mary Joseph's nodules. A 51-year-old man presented with an umbilical mass. Surgical biopsy showed infiltrating neoplasm with glandular and focal papillary architecture. FDG PET/CT demonstrated a focus of abnormal uptake located in the umbilicus, without evidence of a primary tumor elsewhere. Further investigations with EGD, colonoscopy, and cystoscopy were all negative for a neoplasm. The whole-body FDG PET/CT is an ideal imaging modality for evaluation of an umbilical lesion, especially identification or exclusion of a primary neoplasm elsewhere.

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Umbilical Metastasis From Breast Cancer Detected by FDG PET

Cited by 5 publications

References 8 publications

Metabolic Positron Emission Tomography Imaging in Cancer Detection and Therapy Response

Metabolic Positron Emission Tomography Imaging in Cancer Detection and Therapy Response

Sister Mary Joseph Nodule in Endometrial Carcinoma

Primary Umbilical Neoplasm Demonstrated on FDG PET/CT

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