Umbilical remnant allograft application in the treatment of erosive pustular dermatosis of the scalp

Buttars, Benjamin; Rashid, Zaina; Rubaie, Vian Al

doi:10.1016/j.jdcr.2022.03.001

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Due to its inherent structural, performance, and biocompatibility characteristics, the dHUCP device is aptly designed for hard-to-heal wounds. In a non-sponsored third-party case, an umbilical cord particulate product was used to treat a chronic, crusted ulceration on the parietal aspect of the scalp that had persisted for one year [ 57 ]. The patient had failed to respond to corticosteroid treatment for 8 weeks prior to treatment with the umbilical cord particulate product.…”

Section: Discussionmentioning

confidence: 99%

A Novel Dehydrated Human Umbilical Cord Particulate Medical Device: Matrix Characterization, Performance, and Biocompatibility for the Management of Acute and Chronic Wounds

Croteau,

Buckley,

Mantay

et al. 2024

Bioengineering

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Chronic wounds present a significant socioeconomic burden forecasted to increase in prevalence and cost. Minimally manipulated human placental tissues have been increasingly employed and proven to be advantageous in the treatment of chronic wounds, showing improved clinical outcomes and cost-effectiveness. However, technological advances have been constrained by minimal manipulation and homologous use criteria. This study focuses on the characterization of a novel dehydrated human umbilical cord particulate (dHUCP) medical device, which offers a unique allogeneic technological advancement and the first human birth tissue device for wound management. Characterization analyses illustrated a complex extracellular matrix composition conserved in the dHUCP device compared to native umbilical cord, with abundant collagens and glycosaminoglycans imbibing an intricate porous scaffold. Dermal fibroblasts readily attached to the intact scaffold of the dHUCP device. Furthermore, the dHUCP device elicited a significant paracrine proliferative response in dermal fibroblasts, in contrast to fibrillar collagen, a prevalent wound device. Biocompatibility testing in a porcine full-thickness wound model showed resorption of the dHUCP device and normal granulation tissue maturation during healing. The dHUCP device is a promising advancement in wound management biomaterials, offering a unique combination of structural complexity adept for challenging wound topographies and a microenvironment supportive of tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

A Novel Dehydrated Human Umbilical Cord Particulate Medical Device: Matrix Characterization, Performance, and Biocompatibility for the Management of Acute and Chronic Wounds

Croteau,

Buckley,

Mantay

et al. 2024

Bioengineering

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“…In addition, silicone dressing can be used after any minimally invasive modality, such as curettageassisted photodynamic therapy (PDT), to enhance healing and decrease postprocedure inflammation [8]. Interestingly, case reports indicate that newer innovative dressings with umbilical remnant allograft and dehydrated human amnion/chorion membrane allograft can be successful in resistant cases of EPD [82,83].…”

Section: Wound Dressings/allograftsmentioning

confidence: 99%

“…These authors have witnessed the efficacy of a novel silicone gel dressing used after curettage-assisted ALA-PDT [8,63]. Interestingly, case reports indicate that newer innovative dressings with umbilical remnant allograft and dehydrated human amnion/chorion membrane allograft can be successful in resistant cases of EPD [82,83].…”

Section: Therapeutic Challenges and The Search For Treatment Algorithmmentioning

confidence: 99%

Erosive Pustular Dermatosis: Delving into Etiopathogenesis and Management

Bhargava

Yumeen

Henebeng

et al. 2022

Life

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Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that usually affects mature individuals. It predominantly affects the scalp and can lead to scarring alopecia. Risk factors include actinic damage and androgenetic alopecia. A traumatic insult to the skin is considered a vital trigger of the condition. EPD is a diagnosis of exclusion; thus, several neoplastic, infectious, vesiculobullous, and inflammatory conditions should be ruled out. Biopsy and clinicopathologic correlation are required to differentiate between EPD and these entities. A dysregulated, chronic immune response is considered central to the etiopathogenesis of EPD. We performed an evidence-based systematic review of the management options. There were predominantly studies with level IV and V evidence and only two with level III. Despite the responsiveness of EPD to potent topical steroids, such as clobetasol propionate, recurrence occurs after treatment withdrawal. With the available data, tacrolimus 0.1%, curettage-assisted aminolevulinic acid-photodynamic therapy, and systemic retinoids can be considered second-line options for EPD with a role in maintenance regimens. However, controlled data and more powerful studies are needed to make solid recommendations.

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An 81-Year-Old Woman With Erosions and Pustules Affecting Her Scalp

2023

Clinical Infectious Diseases

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Umbilical remnant allograft application in the treatment of erosive pustular dermatosis of the scalp

Cited by 3 publications

References 11 publications

A Novel Dehydrated Human Umbilical Cord Particulate Medical Device: Matrix Characterization, Performance, and Biocompatibility for the Management of Acute and Chronic Wounds

A Novel Dehydrated Human Umbilical Cord Particulate Medical Device: Matrix Characterization, Performance, and Biocompatibility for the Management of Acute and Chronic Wounds

Erosive Pustular Dermatosis: Delving into Etiopathogenesis and Management

An 81-Year-Old Woman With Erosions and Pustules Affecting Her Scalp

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